Low incidence of pachydrusen in central serous chorioretinopathy in an Indian cohort

Purpose: The aim of this study is to report the prevalence, clinical and swept-source optical coherence tomography (SS-OCT) characteristics of pachydrusen in eyes with central serous chorioretinopathy (CSCR) and their fellow eyes. Methods: A total of 264 eyes of 132 patients with a diagnosis of CSCR (acute/persistent/recurrent/chronic/inactive) in atleast one eye, were analyzed in this retrospective, cross-sectional study. SS-OCT parameters including choroidal thickness (CT), large choroidal vessel layer thickness (LCVT) at fovea and the site of pachydrusen were recorded. Paired t test and analysis of variance (ANOVA) was used to compare CT in eyes with CSCR (subfoveal and site of pachydrusen) and multiple groups respectively. Results: The mean age of the study patients was 42.9 � 9.5 years with 119 males (90.15%). Bilateral CSCR was present in 31 patients. Nine eyes (chronic, 4; persistent, 2; and inactive/resolved CSCR, 3) showed presence of pachydrusen with an overall prevalence of 6.82% (9 eyes of 9 patients out of 132 patients). There was no significant difference of subfoveal CT (SFCT) in eyes with CSCR (422.4 � 107.8 ?) vs fellow eyes (407.0 � 96.5 ?) and eyes with CSCR associated with pachydrusen (413.7 � 101.5 ?) vs fellow eyes of CSCR eyes with pachydrusen (431.6 � 188.8 ?) (P = 0.71). LCVT as a percentage of CT was higher at the site of pachydrusen compared to SFCT (69.8% vs. 50.8%). Conclusion: CSCR can be associated with pachydrusen with a lower prevalence rate than previously reported. Whether the thickened large choroidal vessels at site of pachydrusen play any role in formation in pachydrusen needs further evaluation.

Pachydrusen in polypoidal choroidal vasculopathy in an Indian cohort

Purpose: To report the prevalence of pachydrusen and their relationship with subfoveal choroidal thickness (SFCT) and large choroidal vessel layer thickness (SF-LCVT) in eyes with polypoidal choroidal vasculopathy (PCV) and their fellow eyes. Methods: The case records of 50 patients (99 eyes; 59 PCV and 40 fellow eyes) were retrospectively analyzed for the presence of pachydrusen and other drusen types such as soft drusen. The diagnosis was established using colour fundus photography and optical coherence tomography (OCT). SFCT and SF-LCVT were measured and correlated with the different types of drusen. Results: The mean age of the study cohort was 62.26 ± 10.67 years and included 27 males and 23 females. Pachydrusen and soft drusen were seen in 14 (PCV: 8 and fellow eyes: 6) and 8 eyes (PCV: 2 and fellow eyes: 6) respectively. The mean SFCT and SF-LCVT in the eyes with and without pachydrusen was not significanty different (280.29 ± 103.11 ? vs. 292.63 ± 87.17 ?; P = 0.63 and 180.57 ± 59.20 vs. 173.73 ± 54.86 ?; P = 0.67, respectively). The pachydrusen were most commonly located near the vascular arcades and showed scattered distribution pattern. Though SFCT and SF-LCVT was lower in the eyes with soft drusen compared to eyes with pachydrusen, it failed to reach statistical significance (SFCT, P = 0.1 and SF-LCVT, P = 0.06). Conclusion: The prevalence of pachydrusen in PCV and their fellow eyes is lower in Indian population suggestive of ethnic variations. SFCT and SF-LCVT was not noted to vary signifcantly in eyes with and without pachydrusen in this study cohort.

Analysis of different choroidal stratification thickness under macular fovea in patients with early graves ophthalmopathy / 国际眼科杂志(Guoji Yanke Zazhi)

@#AIM: To compare the difference of choroidal delamination thickness in macular fovea between patients with early active Graves ophthalmopathy and healthy subjects by optical coherence tomography(OCT)enhanced deep imaging.<p>METHODS:From December 2017 to May 2019, patients with early active Graves ophthalmopathy diagnosed in our hospital(GO group)and 31 patients(62 eyes)with age and sex matched healthy physical examination(control group)were selected. Diopter, best-corrected visual acuity(BCVA), intraocular pressure, exophthalmos, EDI-OCT and other examinations were performed on all the subjects. The differences of macular central concave choroidal thickness(SFCT), choroidal macrovascular layer thickness(LCVT)and choroidal capillary layer/middle vascular layer thickness(MCVT)between the two groups were compared.<p>RESULTS: There was no significant difference in equivalent spherical lens power, BCVA and eye axis between the two groups. However, the IOP(17.22±2.67mmHg), exophthalmos(15.44±0.92mm), SFCT(315.79±14.99μm), LCVT(234.66±14.90μm)in GO group were significantly higher than those in control group(13.35±1.54mmHg, 12.90±1.00mm, 239.00±12.67μm, 159.16±13.30μm)(all <i>P</i>Symbol|@@0.05), but there was no significant difference in MCVT between the two groups(81.13±7.46μm <i>vs</i> 80.13±7.63μm, <i>P></i>0.05).<p>CONCLUSION: SFCT and LCVT in patients with early active Graves ophthalmopathy are thickened, and MCVT has no obvious change, suggesting that EDI-OCT measurement of SFCT and LCVT has certain reference value for evaluating early active Graves ophthalmopathy.

Vascular behavior characteristics in degenerative retinopathy and its influence factors / 眼科新进展

Vascular morphology and function changes exist in degenerative retinopathy,which have an important influence on the development and prognosis of the disease.The literature has been reported that retinal vascular structure and function change can be found early by using the retinal oximeter,color Doppler flow imaging,ocular pulse amplitude and so on,as well as exploring the primary and secondary factors affecting the development of retinal blood vessels.This article reviews the vascular behavior characteristics in degenerative retinopathy and their influence factors.

Choroid in Myopic Choroidal Neovascularization Measured Using SD-OCT

PURPOSE: Using the spectral domain optical coherence tomography (SD-OCT), we studied the difference in the choroidal morphology between the choroidal neovascularization (CNV) area and the area surrounding CNV. METHODS: This retrospective study consisted of 19 patients with myopic CNV lesion in eye; fellow eyes were used as controls. All eyes were analyzed by measuring the choroidal thickness and large choroidal vessel size using SD-OCT. Eyes with CNV were divided into groups; the neovascular lesion was defined as group 1, the surrounding area as group 2. Subfovea of the fellow eye was defined as group 3. RESULTS: The choroidal thickness was 80.00 +/- 68.31 in group 1, 63.44 +/- 67.75 in group 2 and 71.11 +/- 65.69 microm in group 3. There was a significant difference between group 1 and group 2 (p = 0.038). There were no significant differences between group 1 and 3 or between group 2 and 3 (p = 0.365, p = 0.314). The large choroidal vessel size was 57.47 +/- 39.78 in group 1, 40.45 +/- 34.69 in group 2 and 45.63 +/- 37.00 microm in group 3. There was a significant difference between group 1 and group 2 (p = 0.025). There were no significant differences between group 1 and 3 or between group 2 and 3 (p = 0.123, p = 0.325). CONCLUSIONS: Choroidal thickness and large choroidal vessel size at the center of the CNV were greater than in the area surrounding CNV. The results suggest that although the CNVs were due to a thinned choroid caused by severe choroidal ischemia, the development of CNV requires maintenance of choriocapillaris and large choroid vessels.