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Abstract Objectives This study aims to evaluate the dynamics of clinical and laboratory indicators of the periodontal state and hemodynamics in patients receiving pharmaceutical intervention for the treatment of vitamin D deficiency as a part of the complex therapy of chronic generalized periodontitis. Methodology This was a randomized prospective comparative clinical trial. It involved 110 patients with moderate generalized periodontitis and vitamin D deficiency (25(OH)<50 nmol/L) who were divided into two experimental groups. One experimental group received conventional treatment, whereas the other group received conventional treatment with pharmaceutical intervention for the treatment of vitamin D deficiency(vitamin D3 + calcium). Results A significant reduction in periodontal inflammation was observed across all study groups starting from day 14 of treatment. However, in a longer perspective (12 and 18 months after treatment), the indices analyzed remained fairly stable and corresponded to the chronic periodontitis clinical stabilization stage in both groups. The conventional treatment group demonstrated a marked tendency for all indicators to return to the baseline. Conclusions Pharmacotherapy of vitamin D deficiency contributed to the normalization of periodontal microcirculation (the σ and Kv values approached those of healthy periodontium) as evidenced by the immediate and long-term follow-up results. Clinical observation of patients suffering from moderate chronic generalized periodontitis with underlying hypovitaminosis D makes an argument to the use of vitamin D supplementation for the correction of vitamin D deficiency as a part of the complex treatment. Trial registration number: NCT67823273
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Aim: The aim of this study is to compare the CRP levels and leucocyte counts in patients with Sickle cell anemia, Sickle cell anemia with chronic periodontitis, and chronic periodontitis. Material andMethods: A total of 90 subjects with an age range of 30-50 years having sickle cell anemia and chronic periodontitis with probing depth ≥5mm and clinical attachment level ≥ 5mm were included and three groups: Group I- Sickle cell anemia; Group II- Sickle Cell anemia with chronic periodontitis and Group III: Chronic severe periodontitis. Blood samples for CRP and leucocytes counts estimation were collected. All participants were subjected to quantitative CRP analysis. Results: Mean CRP levels and leucocyte counts were significantly greater in group II as compared to group I and group III. Conclusion: The present study indicates a positive correlation in CRP levels and leucocyte counts in patients with Sickle cell anemia, chronic periodontitis and both.
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Anaemia of chronic disease (ACD) is caused due to an underlying chronic inflammatory process. It is not due to marrow deficiency of iron. Chronic periodontitis is a chronic inflammatory condition which has been associated with anaemia of chronic disease. The aim of this study is to estimate various hematologic parameters suggestive of ACD in patients with chronic periodontitis and in the process to establish a relation between the two. Forty patients were selected and were categorized, based on the presence and absence of chronic periodontitis, into case and control groups, with 20 subjects in each group. Hematologic evaluation was done. Complete haemogram, haematocrit, erythrocyte sedimentation rate (ESR) and estimation of serum ferritin were done. An independent t-test was calculated. Statistically significant values (p<0.05) were obtained for neutrophil count, ESR, red blood cells (RBC), mean corpuscular haemoglobin concentration (MCHC) and serum ferritin. ESR, RBC and serum ferritin levels were significantly increased in subjects with chronic periodontitis. There were significant differences in neutrophil, ESR, RBC and serum ferritin in subjects having severe form of generalized chronic periodontitis. Thus, it was concluded that chronic generalized periodontitis, by means of an inflammatory process, influences various hematologic parameters are suggestive of anaemia of chronic disease.