Discussion on drug dosage in Treatise on Febrile Diseases / 中国中药杂志

This article aimed to discuss,the dosage problems in the first 100 published classic prescriptions,mainly on the dosage units involved in Treatise on Febrile Diseases. The dosage units were mainly classified into three types: weight unit,volume unit and length unit. The volume unit and length unit are basically not controversial. The weight unit is more problematic. Through textual research,measured data and the calculation by State Administration of Taxation on unearthed cultural relics,the basis for the weights and measures in the Han Dynasty was clarified,namely glutinous rice( Shu). The Zhu-Liang system was adopted for weight measurement,and the weight of glutinous rice( Shu) was used to measure the weight of others, " 1 Liang = 24 Zhu = 240 Lei = 2 400 Shu". Sheng-He system was adopted for volume measurement,and the volume of the glutinous rice( Shu) was used to measure the volume of others, " 1 Sheng = 10 He = 20 Yue = 24 000 Shu". The width of the glutinous rice( Shu) was used to measure the length, " 1 Chi = 10 Cun =100 Fen = 100 Shu". At the same time,the conversion relationship between ancient dosage units in Treatise on Febrile Diseases and modern dosage units was clarified in this paper, " 1 Jin = 250 g,1 Liang = 15. 625 g,1 Zhu = 0. 65 g", " 1 He = 20 m L,1 Sheng =200 m L", " 1 Chi = 23 cm,1 Cun = 2. 3 cm". Through research,it is found that the weight measurement in the Han Dynasty was " glutinous rice system",which was based on " glutinous rice",providing a powerful key to solve the weight disputes in the classic prescriptions. Through the combination of textual research and physical testing,disputes can be eliminated more quickly,and an " expert consensus" can be formed on the weight issues. The definite drug dosage in Treatise on Febrile Diseases can provide convenience for the clinical prescription system,and provide a dose basis for the development of the classic preparations.

Study on classic preparations / 中国中药杂志

In this paper, classic preparations in Treatise on Febrile Diseases were systematically investigated to obtain their process parameters, and provide literature evidence and technical support for drug research and development. This paper includes the following sections: drug dose, solvents, excipients, and process parameters of classic preparations. The drug dose in Treatise on Febrile Diseases was not consistent with that in Pharmacopoeia of the People's Republic of China 2015, for example, "Yi-Liang" was about 15.625 g, and "Yi-Sheng" was about 200 mL. The solvents of classic preparations can be divided into two types: wine and water. There were eight kinds of water: water, "Dongliu water" "Ganlan water" "acid pulp" "Jinghua water" "Lao water" "Mafei Tang" "spring water". There four kinds of wines: "wine" "Bai wine" "Qing wine" "Ku wine". There were two kinds of excipients: rice and honey. Classic prescription powder had two kinds of processes: "whole prescription powder" and "Yidaoshai Hezhizhi powder". Classic prescription pills had three kinds of processes: direct whole prescription pilling, pilling after extraction, and pilling with excipients after smashing. Classic prescription decoction had six kinds of processes: "wine Tang", "Mafei Tang", "Jingmi Tang", "Mijian Tang", "water Tang" "Zhugao Tang". Drug dose, solvents, excipients, processes and other key parameters of classic preparations were systemically reviewed in this study, and the process parameters were clarified to provide literature evidence and technical support for drug development.