Clinical Efficiency and Safety of Hypofractionated Thoracic Radiotherapy Combined with EP Chemotherapy on Patients with Limited-stage Small-cell Lung Cancer / 肿瘤防治研究

Objective To investigate the efficacy and safety of hypofractionated thoracic radiotherapy combined with EP chemotherapy in the treatment of limited-stage small-cell lung cancer (LS-SCLC). Methods A total of 117 patients with LS-SCLC were enrolled and randomly divided into test group (n=59) and control group (n=58). Patients in the experiment group were given hypofractionated thoracic radiotherapy combined with EP chemotherapy, while patients in the control group were given hyperfractionation radiotherapy combined with EP chemotherapy. Objective response rate (ORR), 2-year overall survival (OS), 2-year progression free survival (PFS), and immune cell level were used to evaluate clinical efficacy. We compared the incidence of side effects between the two groups. Results After the treatment, the ORR of patients in the test group was higher than that in the control group (P > 0.05). The mean OS and PFS of patients in the test group were significantly longer than those in the control group (P < 0.05). The levels of CD3+, CD4+, CD4+/CD8+, and NK cells in the test group were significantly higher, whereas the levels of CD8+ were significantly lower than those in the control group (P < 0.05). The incidence of radiation pneumonitis, radiation esophagitis, and severe dermatitis in the test group was significantly lower than that in the control group (P < 0.05). Conclusion Hypofractionated radiotherapy combined with EP chemotherapy for treatment of LS-SCLC can effectively improve the anticancer efficacy and patient survival, reduce the damage to the body's immune function, and alleviate adverse reaction of radiotherapy.

Clinical efficiency of holmium laser enucleation of the prostate for small-volume benign prostatic hyperplasia with severe LUTS / 中华男科学杂志

Objective@#To evaluate the safety and clinical efficiency of holmium laser enucleation of the prostate (HoLEP) in the treatment of small-volume BPH (SBPH) complicated by severe lower urinary tract symptoms (LUTS).@*METHODS@#We retrospectively analyzed the clinical data on 82 cases of SBPH with severe LUTS treated by HoLEP from January 2017 to December 2018. The patients were aged (65.5 ± 7.6) years, with a mean prostate volume of <40 ml, a total IPSS of 24.8 ± 4.6, a QOL score of 5.2 ± 0.8, the maximum urinary flow rate (Qmax) of (7.6 ± 3.7) ml/s, and a mean PSA level of (1.8 ± 1.4) μg/L.@*RESULTS@#All the operations were successfully completed, the mean operation time averaging (30.2 ± 5.0) min, enucleation time (26.7 ± 5.6) min and comminution time (3.5 ± 1.1) min, and the enucleated tissue weighing (20.3 ± 4.9) g. After surgery, the bladders were irrigated for (3.5 ± 1.9) h, with (3.0 ± 1.7) L of rinse solution, and catheterization lasted (24.8 ± 9.7) h. Histopathology revealed moderate or severe lymphocytic infiltration in 69 cases (84.1%). At 6 months after operation, significant improvement was observed in the IPSS, QOL, Qmax and PSA level compared with the baseline (P < 0.05). To date, no urethral stricture-related reoperation was ever necessitated.@*CONCLUSIONS@#HoLEP is safe and effective for the treatment of SBPH complicated by severe LUTS and can be employed after adequate preoperative evaluation of the patient.《.

Clinical characteristics of five traditional Chinese medicine injections in treating heart failure based on Meta-analysis literature / 中国中药杂志

In this article, we analyze the clinical characteristics of five kinds of traditional Chinese medicine injections in treating heart failure based on Meta-analysis. A total of 24 Meta-analysis papers were included, which involved Shenfu Injection, Shenmai Injection, Shengmai Injection, Danhong Injection and Huangqi Injection. The numbers of literatures of Shenfu Injection, Shenmai Injection and Shengmai Injection are high than the other two injections. The efficiencies of these injections combined with Western medicine are higher than the Western medicine used alone. They can improve 6 minute walk test result, ejection fraction, the level of brain peptide sodium and so on. Shenfu Injection can also improve the living quality of patients' life, heart rate and other indicators. Shenfu Injection can be used for patients with Yin deficiency, while Shenmai Injection can be used for patients with Yin deficiency and Shengmai Injection can be used for patients with Qi and Yin deficiency. From this information, we can see that Western medicine combined with traditional Chinese medicine injections can significantly improve the clinical efficiency. These injections need to be used according to patients' symptom. In the present, as the quality of clinical research literature of traditional Chinese medicine injections is low, the efficiency and safety evaluation of Chinese medicine injections still requires higher level of clinical evidence.

Shang Ring versus disposable circumcision suture device in the treatment of phimosis or redundant prepuce / 中华男科学杂志

<p><b>Objective</b>To compare the clinical efficiency of Shang Ring with that of the disposable circumcision suture device (DCSD) in the treatment of phimosis or redundant prepuce.</p><p><b>METHODS</b>From June 2013 to March 2015, we treated 320 patients with phimosis or redundant prepuce using Shang Ring (n=158) or DCSD (n=162). We compared the operation time, intra-operative blood loss, incision healing time, postoperative complications, postoperative satisfaction, and treatment cost between the two groups of patients.</p><p><b>RESULTS</b>Comparison between the Shang Ring and DCSD groups showed that the operation time was (5.6±1.3) vs (5.4±1.2) min, intra-operative blood loss (1.2±0.8) vs (1.3±0.9) ml, postoperative delayed hemorrhage 3.16% (5/158) vs 4.32% (7/162), incision healing time (16.1±7.2) vs (7.5±2.3) d, wound infection 15.82% (25/158) vs 7.41% (12/162), 1-month postoperative incision edema 29.11% (46/158) vs 9.26% (15/162), overall postoperative satisfaction rate 63.92% (101/158) vs 90.12% (146/162), and treatment cost (1121.2±15.6) vs (2142.6±10.8) RMB ¥. There were statistically significant differences between the two groups in the latter five parameters (P<0.05 ), but not in the first three (P>0.05 ).</p><p><b>CONCLUSIONS</b>The DSCD has an obvious superiority over Shang Ring for its relatively lower complication rate, shorter incision healing time, and better cosmetic appearance.</p>

The clinical comparative study of tension-free repair under local anesthesia and transabdominal preperitoneal for hernioplasty / 中国医师进修杂志

Objective To compare the clinical efficiency of tension-free repair(Lichtenstein) under local anesthesia and transabdominal preperitoneal (TAPP) for hernioplasty.Methods The clinical data of 120 patients with Lichtenstein for hernioplasty under local anesthesia (Lichtenstein group) and 98 patients with TAPP for hemioplasty (TAPP group) from January 2010 to July 2012 were analyzed.Results The operation time,blood loss and number of concurrent hernia found in the operation in Lichtenstein group was significantly lower than that in TAPP group [(40.1 ± 4.5) min vs.(45.7 ± 3.5) min,P ＜ 0.01 ; (6.7 ± 1.3) ml vs.(10.6 ± 2.3) ml,P ＜ 0.01 ; 10.2％ (10/98) vs.1.7％ (2/120),P =0.006].In Lichtenstein group,the frequency of analgesic drug used in 3 d after operation,time of return to regular activity were significant higher than those in TAPP group [(0.31 ± 0.03) times vs.(0.22 ± 0.09) times,(9.32 ± 1.38) d vs.(6.54 ±0.98) d],but the time to ambulation,hospital stay,and cost were lower[(5.34 ± 1.98) h vs.(10.24 ± 2.35)h,(2.98 ± 1.32) d vs.(6.43 ±0.93) d,(5032.15 ±372.18) yuan vs.(8325.76 ±438.23) yuan](P=0.010).The rate of complications had no significant difference between two groups (P =0.067).The rate of chronic pain in Lichtenstein group was significantly higher than that in TAPP group [10.0％(12/120) vs.0,P =0.001].The rate of real recurrent hernias in Lichtenstein group had no significant difference compared with TAPP group (P =0.199),but the rate of false recurrent hernias in Lichtenstein group was significantly higher than that in TAPP group [6.7％(8/120) vs.0,P =0.009].Conclusion Both of Lichtenstein under local anesthesia and TAPP for hemioplasty are safety and effective,and each has its advantages.

A comparative study of the clinical efficiency of escitalopram and paroxetine in treatment of obsessive-compulsive disorder / 中华行为医学与脑科学杂志

Objective To investigate the difference of clinical efficiency and safety in obsessive-compulsive disorders (OCD) treatment with escitalopram or paroxetine.Methods A total of 156 OCD patients were randomly divided into escitalopram group (ESC group) and paroxetine group (PAR group).Yale-Brown Obsessive Compulsive Scale (Y-BOCS),Hamilton Depression Scale (HAMD) and Treatment Emergent Symptom Scale (TESS)were used to evaluate the clinical efficiency and safety before and after1,2,4,6,8 weeks treatment.Results The cure rate(21.79％ vs 17.95％) and effective rate(70.51％ vs 71.79％) had no statistically difference between ESC group and PAR group,and incidence of side effect had no significant difference between two groups(x2 =1.99,P＞0.05).Compared with the group before treatment,HAMD scores were significantly decreased from the first weekend in ESC group,but in PAR group HAMD scores did not decrease until the second weekend,and the differences were also significant(P＜0.05).Conclusion Escitalopram is a safety,effective and well-tolerated drug in the treatment of obsessive-compulsive disorder.

A comparative study of the clinical efficiency of chemomechanical caries removal using Carisolv® and Papacarie® - A papain gel.

Objectives: The purpose of this study was to compare the clinical efficiency of chemomechanical caries removal using Carisolv® and Papacarie® - a papain gel. Materials and Methods: The Carisolv® system for caries removal, consisting of a solvent gel and a specially designed hand instrument, was compared to Papacarie - a papain gel. The outcome variables were: time taken for complete caries removal and volume of carious tissue excavated. Forty patients in the age-group of 20-40 years, having Black's class I dentinal caries with cavity entrance size of ≥3 mm in the molars, were enrolled for the study. The time taken for the complete removal of caries was measured using a stopwatch. Pre- and post-excavation single-step putty/wash elastomeric impression was recorded using addition silicone impression material. Subsequently, casts were poured and measured under a traveling microscope. The total volume of caries excavated was computed using the formula π (d/2)2 h. The difference between the two groups in clinical efficiency and volume excavated was statistically analyzed using the Student's unpaired 't' test. Results: The time for caries removal with Carisolv® and Papacarie® were, respectively, 11.67 ± 3.25 minutes and 10.48 ± 2.96 minutes (P>.05). The mean volume of carious tissue removed with Papacarie® (135.99 ± 66.43 mm 3 ) was higher than that with Carisolv® (126.33 ± 53.56 mm 3 ); however, the difference was not significant. Conclusion: Carisolv® and Papacarie® have similar clinically efficiency as chemomechanical agents for dentinal caries removal.

Observation on clinical efficacy of domestic made doxycycline powder injection on urinary and reproductive infection / 重庆医科大学学报

0.05).Conclusion:Domestic made doxycycline powder injection is effective and safe for the treatment of urinary and reproductive infection.