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Objective To study and discuss the clinical effect of continuous renal replacement therapy (CRRT) in the treatment of patients with sepsis in intensive care unit ( ICU). Methods From January 2014 to February 2017,100 patients with sepsis in the ICU of Yuncheng Central Hospital were selected and randomly divided into control group and observation group,with 50 cases in each group. The control group was treated with hemoperfu-sion treatment,the observation group was treated with CRRT. The blood coagulation function,clinical efficacy,renal function,inflammatory factors index were compared between the two groups. Results The total effective rate of the observation group was 96％ ,which was significantly higher than 80％ of the control group (χ2 = 6. 061,P < 0. 05). After treatment,the blood creatinine,urea nitrogen in the observation group were (94. 09 ± 20. 69)μmol/ L,(8. 94 ± 2. 87)mmol/ L,respectively,which were lower than those in the control group [(119. 43 ± 26. 57)μmol/ L,(12. 37 ± 3. 70)mmol/ L] (t = 5. 321,5. 180,all P < 0. 05). The APTT,PT of the observation group were (19. 10 ± 2. 14)s, (8. 24 ± 0. 97) s,respectively,which were shorter than those of the control group [(21. 84 ± 2. 75) s,(9. 32 ± 1. 15)s] (t = 5. 560,5. 076,all P < 0. 05). The levels of CRP,IL - 6 of the observation group were (8. 32 ± 1. 89)mg/ L,(109. 53 ± 36. 29) ng/ L,respectively,which were lower than those of the control group [(12. 65 ± 3. 47)mg/ L,(148. 36 ± 43. 64) ng/ L] ( t = 7. 749,4. 838,all P < 0. 05). Conclusion CRRT treatment for the sepsis patients during ICU monitoring can effectively improve the clinical curative effect,improve renal function, reduce the damage of blood coagulation function,inhibit the inflammatory reaction in the body,and is beneficial for the prognosis.
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Objective To investigate the changes of immune function and blood coagulation function in pa-tients with pulmonary tuberculosis(PTB)with chronic obstructive pulmonary disease(COPD)and its correla-tion with lung function.Methods 65 cases of PTB patients with COPD were selected as PTB with COPD group,50 cases of patients with PTB were selected as PTB group,another 50 healthy people were selected as control group;the level of immune function and coagulation function were compared between the three groups,and the relationship between immune function,coagulation function and pulmonary function was ana-lyzed.Results The differences of CD3+,CD4+,CD4+/CD8+,TT,APTT,PT,FIB,FEV1,FVC and MMEF between the three groups were statistically significant(P<0.05);The levels of CD3+,CD4+,CD4+/CD8+, APTT,FEV1,FVC and MMEF in PTB group and PTB group with COPD were significantly lower than those in control group,and PTB group with COPD group was significantly lower than that in PTB group,the differ-ence was statistically significant(P<0.05);The levels of TT and FIB in PTB group and PTB group with COPD were significantly higher than those in control group,and PTB group with COPD group was significant-ly higher than that in PTB group,the difference was statistically significant(P<0.05);The results of corre-lation analysis showed that FEV1,FVC and MMEF had significant positive correlation with CD3+,CD4+, CD4+/CD8+,APTT and PT(P<0.05),and negatively correlated with TT and FIB(P<0.05),and there was no significant correlation between FEV1,FVC,MMEF and CD8+(P>0.05).Conclusion The patients with PTB accompanied with COPD have abnormal cellular immune function and abnormal coagulation func-tion,and the level is significantly correlated with lung function.
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AIM: To investigate the clinical effect of Maiditong for injection(Herba Erigerontis) on coagulative and fibrionlytic system in diabetic nephropathy(DN). METHODS: 59 patients definitely diagnosed as diabetes type 2 DN were randomly divided into treatment and control groups.The treatment group were treated with Maiditong for injection,and the control group were treated with of Compound Danshen Injection.The 24 h proteinuria and vWF:Ag、Fbg、PF_(1+2)、FPA、D-dimer、AT-Ⅲ:A、tPA、PAI-1、PIC、PLG were tested before and after the therapies. RESULTS: After one therapy course(2 weeks),in the treatment group the 24 h proteinuria decreased obviously(P