O idoso com comprometimento cognitivo apresenta pior condição de saúde bucal? / Do elderly individuals with a cognitive handicap have worse oral health?

A saúde bucal dos idosos sem comprometimento cognitivo foi comparada com a daqueles com comprometimento. A condição cognitiva, o índice de dentes cariados perdidos e obturados (CPOD), o índice de raízes cariadas e obturadas (COR), a necessidade de tratamento dentário, a presença de placa (P) e cálculo (C), o índice periodontal comunitário (CPI), o índice de perda de inserção periodontal (PIP), o edentulismo, o uso de prótese e a necessidade de prótese foram avaliados em uma amostra complexa probabilística por conglomerados de idosos (65-74 anos). Usou-se o PASW(r) 17.0 nas análises estatísticas com correção pelo efeito de desenho, através dos testes Mann Whitney e qui quadrado com 95% de confiança. Foram entrevistados e examinados 736 idosos. Os com comprometimento cognitivo apresentaram maiores médias de CPOD, COR e menores médias de sextantes sadios do CPI, prevalências menores de sextantes sem placa/cálculo e de uso de prótese; maiores prevalências de edentulismo e necessidade de próteses. Idosos com comprometimento cognitivo apresentaram pior saúde bucal.

A comparison of the oral health of elderly people with and without a cognitive handicap was assessed. The cognitive condition, the indices of decayed, missing, filled teeth (DMFT), decayed, filled roots (DFR), the need for dental treatment, the presence of plaque (P), calculus (C), the community periodontal index (CPI), the rate of periodontal attachment loss (PAL), edentulism, prosthetic use and the need for prosthetics were evaluated in a complex probabilistic sample by conglomerates of the elderly (65-74 years). PASW(r) 17.0 was used for the statistical analyses with correction for the design effect, applying the Mann Whitney and chi-square test with 95% reliability. A total of 736 elderly individuals were interviewed and examined. Those with cognitive impairment had higher average DMFT, DFR and lower average healthy sextant CPI, a lower prevalence of sextants without plaque/calculus, use of prosthetics and higher prevalence of edentulism and need for prosthetics. Elderly individuals with a cognitive handicap had poorer oral health.

Effect of Aβ1-42 injection on hippocampus cells in rats and protective role of polygona-polysaccharose for Alzheimer’s disease / 中南大学学报(医学版)

Objective: To determine the effect of polygona-polysaccharose (PP) on learning and memory ability in rats with Alzheimer’s disease (AD). Methods: Forty ifve Sprague-Dawley rats were assigned into 3 groups. Rats in the sham-operated group were injected with normal saline. Rats in the Aβ group were injected with Aβ1-42. Rats in the PP group were injected with 16% PP solution for 45 days consecutively. hTe Morris water maze was used to investigate the ability of learning and memory in the rats. hTe effect of Aβ and PP on the hippocampus cells was observed by HE and Congo red staining of methanol. Results: Rats in the sham-operated group had no obvious morphological change; and morphology of rats in the PP group was basicaly normal. The layer of pyramidal cells in the Aβ group was decreased. hTe cells appeared sparse and irregular and became smaller. Karyopyknosis and vacuolardegeneration cells were also found. More positive staining materials aggradated in the Aβ group compared with the PP group by Congo red staining (P<0.05). Conclusion: Aβ infusion into the hippocampus results in the impairment of the neuronal degeneration in the rats, which shows similar characterizations of AD. PP can reduce the deposition of Aβ in the hippocampus.

The expression of RGMa and RhoA in the hippocampus of rats with cognitive impairment induced by A? / 重庆医科大学学报

Objective:To observe the expression of RGMa and RhoA in the hippocampus of cognitive impairment rats induced by A?1-40. Methods:Morris water maze was used to study the cognitive function, and reverse transcription-polymerase chain reaction(RT-PCR)method was used to determine the changes of RGMa mRNA and RhoA mRNA expressions. mmunohistochemistry was used to detect the expression of RGMa protein. Results:Model group showed learning and memory impairment, the expression levels of RGMa mRNA and protein in the hippocampus decreased compared with control group(p

Relationship of memory behaviors and changes of synapse structure in vascular dementia rats / 第三军医大学学报

Objective To explore the relationship of the changes of memory behavior and the of changes of the parameter of synapse structure in the brain cortex and hippocampus of chronic cerebral hypoperfusion rats Methods Chronic cerebral hypoperfusion rat model was established by ligating bilateral common carotid arteries of the old rats (over 12 months) The rats were divided into 3 groups, normal, 2 months ischemia, and 4 months ischemia groups The memory behavior changes were observed with a computerized shuttle training case The ultrastucture of synapse were observed with electron microscopy for the number density, length of activity cord, area of synapses disk, surface density of the synapse, and the results were analyzed with stereology and image analyses The relationship between the behavior and the ultrastructure were studied Results Active avoidance response (AAR) and passive avoidance response (PAR) were decreased in the 2 months ischemia group and the 4 months ischemia group The number density (Nv) of the synapses in the brain cortex and hippocampus were reduced in the 2 months ischemia group and the 4 months ischemia group The length of activity cord (L), the area of synapses disk (S), the area density (Sv) in the hippocampus decreased in the 2 and 4 months ischemia group, and those in the brain cortex did not change in the 2 groups Conclusion The decrease of the number density (Nv) and the length of activity cord (L) of synapses in the chronic cerebral hypoperfusion is related to the memory behavior changes