Effects of combined intervention of isoflavone supplementation and exercise on bone metabolism in growing rats / 한국영양학회지

PURPOSE: This study examined the effects of combined intervention of isoflavones and exercise on bone mineral density, bone mineral content, and biochemical bone markers. METHODS: Forty rats were divided into four groups; Control, Isoflavones (IF), Isoflavones + Running (IFR), and Isoflavones + Swimming (IFS). All of the rats in this study were fed an experimental diet and deionized water ad libitum for nine weeks. Bone mineral density (BMD) and bone mineral content (BMC) were estimated using PIXImus (GE Lunar Co, Wisconsin.) in spine and femur nine weeks after feeding or training. RESULTS: The combined intervention did not affect weight gain, mean food intake, or food efficiency ratio. The serum concentrations of ALP and osteocalcin were not significantly different by combined intervention. The urinary DPD crosslinks values were not significantly different by combined intervention. There were no significant differences in serum PTH, calcitonin, and estradiol among all groups. Spine BMD, spine BMC and femur BMC were not significantly different by combined intervention. However, femur BMD was significantly higher in the IFR group than in the control group. Compared with the control group, spine BMD, spine BMC, and femur BMD per weight were markedly increased in the isoflavones supplementation and combined intervention group. In addition, femur BMC per weight was significantly higher in the IFS group than in the control group. Compared with the isoflavones supplemented group, BMD and BMC were not significantly different by combined intervention. CONCLUSION: It can be concluded that isoflavones supplementation or combined intervention of isoflavone and exercise had a beneficial effect on spine and femur peak bone mass in growing female rats.

Characteristics and Outcome of Elderly Patients with Coronary Artery Disease after Combined Interventional Procedure / 中国康复理论与实践

@#ObjectiveTo investigate the characteristics and outcome of elderly coronary artery disease (CAD) patients who received combined interventional procedures (CIP). Methods69 consecutive patients who underwent CIP were divided into aged group (≥65 years) and adult group (18~65 years). Individualized procedure was made before CIP considering the features of each case. The following items were compared: success rate, complications, mortality, cost, procedure time, X-ray exposured time and contrast dosage used. ResultsThere were no significant differences between the 2 groups in success rate, complications and mortality. But the cost, procedure time, X-ray exposure time and the contrast dosage were significantly higher in the aged group. ConclusionThe elderly patients could get the same clinical results as those young and middle-aged patients from CIP, but the cost, procedure time, and X-ray exposure time and the contrast dosage were significantly higher, that more attention should be paid to the kidney damage caused by contrast.