Two Cases of Compulsive Behavior Successfully Treated with Ryokeijutsukanto / 日本東洋医学雑誌

To date, there have been limited reports on the efficacy of Kampo medicine in treating obsessive compulsive behaviors. To the best of our knowledge, there have been no previous reports on the efficacy of ryokeijutsukanto for obsessive compulsive behaviors. Here, we describe 2 cases of obsessive-compulsive behavior successfully treated with ryokeijutsukanto. Case 1 involved a 30-year-old female patient who presented with vague anxiety. As a result, she spent significant time engaging in compulsive behavior related to checking and was frequently tardy to work. She met the diagnostic criteria for obsessive compulsive disorder. We prescribed ryokeijutsukanto. Her compulsive behavior then improved from 40 minutes to 5 minutes in 56 days. Case 2 involved 57-year-old female patient who complained of not feeling refreshed in the morning. In addition, she had a feeling of gloom, daytime sleepiness and compulsive behavior of checking about 5 times whether windows were locked. We prescribed ryokeijutsukanto. In 14 days, her checking behavior then improved from 5 times to once. Other troublesome symptoms also improved. Ryokeijutsukanto is usually utilized for patients with fluid retention, dizziness, and qi counterflow. However, these 2 cases have qi stagnation rather than qi counterflow. These results suggested that ryokeijutsukanto could also be utilized to treat compulsive behaviors when patients had fluid retention, dizziness and qi stagnation.

Correlation between serum ischemia modified albumin and calmodulin expression levels and neurological impairment in patients with cerebral small vessel disease / 中国基层医药

Objective:To investigate the correlation between serum ischemia modified albumin (IMA) and calmodulin (CaM) expression levels and neurological impairment in patients with cerebral small vessel disease.Methods:The clinical data of 140 patients with cerebral small vessel disease (CSVD) who received treatment at The Third People Hospital in Liaocheng between April 2020 and December 2021 were retrospectively analyzed. On admission, serum levels of CaM and IMA were measured using an enzyme-linked immunosorbent assay and an albumin-cobalt binding test. Patients' neurological function was evaluated using the National Institutes of Health Stroke Scale (NIHSS). Patients' transient cerebral ischemia, urinary incontinence, and gait disturbance were evaluated using the National Institute of Neurological Disorders and Stroke Scale. Patients' cognitive function was evaluated using the Montreal Cognitive Assessment scale. The influential factors of serum IMA and CaM expression levels in patients with CSVD were analyzed. The factors that affect the severity of neuological imairment in patients with CSVD and their correlation with serum IMA and CaM expression levels were analyzed.Results:The gender, age, presence or absence of gait disorders, and presence or absence of urinary incontinence of patients were not correlated with serum IMA and CaM levels (all P > 0.05). The serum levels of IMA [(38.5 ± 5.3) × 103U/L, (38.5 ± 4.7) × 103U/L, (39.0 ± 4.4) × 103U/L] and CaM [(190.4 ± 34.5) μg/L, (191.2 ± 26.7) μg/L, (199.7 ± 24.8) μg/L] in patients with cognitive impairment, dizziness and vertigo, and transient cerebral ischemia were significantly higher than those in patients with normal cognitive function, patients without dizziness and vertigo, or patients without transient cerebral ischemia [(27.3 ± 4.4) × 103U/L, (21.0 ± 3.8) × 103U/L, (20.5 ± 5.1) × 103U/L, (180.6 ± 29.6) μg/L, (179.5 ± 28.6) μg/L, (168.6 ± 32.4) μg/L, t = 14.10, 24.36, 22.50, all P < 0.05]. There were significant differences in cognitive impairment (38/16/9), dizziness and vertigo (39/16/8), transient cerebral hemorrhage (35/16/9), NIHSS score [(3.6 ± 0.8) points, (7.5 ± 0.9) points, (16.2 ± 3.2) points], CaM levels [(125.3 ± 20.5) μg/L, (185.5 ± 23.6) μg/L, (237.9 ± 54.3) μg/L], and IMA levels [(21.2 ± 3.5)] × 103 U/L, [(38.5 ± 4.3) × 103 U/L, (74.9 ± 5.4) × 103 U/L] among patients with mild, moderate, and severe neurological impairment ( t = 32.87, 11.28, 12.42, 34.59, 151.73, 147.84, all P < 0.05). The results of multivariate analysis indicated that cognitive impairment ( OR = 1.578, 95% CI: 1.043-2.386), transient cerebral ischemia ( OR = 2.396, 95% CI: 1.156-4.969), dizziness and vertigo ( OR = 1.906, 95% CI: 1.086-3.345), NIHSS score ( OR = 2.171, 95% CI: 1.162-4.056), CaM level ( OR = 2.022, 95% CI: 1.268-3.224), and increased IMA levels ( OR = 2.090, 95% CI: 1.313-3.325) were independent influential factors for worsened neurological impairment (all P < 0.05). The serum levels of IMA and CaM in patients with CSVD were significantly positively correlated with the severity of neurological impairment ( r = 5.45, 8.33, both P < 0.05). Conclusion:The elevated serum levels of IMA and CaM in patients with CSVD serve as independent risk factors for neurological impairment, and these levels are positively correlated with the severity of neurological impairment.

Clinical diagnoses of patients showing caloric inversion

Abstract Objectives When air irrigation is used for caloric stimulation in patients with a perforated ear, warm irrigation may elicit a nystagmus that initially beats in the opposite direction of what is expected for warm irrigations, which is referred to as "caloric inversion". This study aimed to investigate the disease group in which caloric inversion appeared in patients who underwent caloric testing and to classify the patterns of caloric inversion. Methods We conducted a retrospective review of bithermal caloric test results that were collected in our dizziness clinic between 2005 and 2022. Caloric inversion was defined when nystagmus induced by caloric stimulation appeared in the opposite direction to that expected. The incidence of caloric inversion among all patients who underwent bithermal caloric tests was calculated. To confirm the clinical diagnoses of the patients with caloric inversion, their clinical records were reviewed. Results Out of 9923 patients who underwent bithermal caloric tests, 29 patients (0.29%) showed a caloric inversion. The most common clinical diagnosis was chronic otitis media (21 of 29, 72%). Of the 21 patients with chronic otitis media, 20 patients showed a caloric inversion by warm air irrigation and one patient showed caloric inversion by cold air stimulation. Patients with clinical diagnoses other than chronic otitis media such as sudden sensorineural hearing loss, benign paroxysmal vertigo of childhood and recurrent vestibulopathy showed caloric inversion by warm air irrigation. Caloric inversion by warm water irrigation was observed in patients with lateral semicircular canal cupulopathy and recurrent vestibulopathy. Two patients (one with Meniere's disease and one with age-related dizziness) showed caloric inversion by cold water irrigation. Conclusion Caloric inversion can be observed in various diseases other than chronic otitis media with tympanic membrane perforation. Special care should be taken in the interpretation of caloric test results. Level of Evidence: Level 4.

Additional cognitive behavior therapy for persistent postural-perceptual dizziness: a meta-analysis

Abstract Objective To investigate whether additional Cognitive Behavior Therapy (CBT) combined with conventional therapy improves outcomes for patients with Persistent Postural-Perceptual Dizziness (PPPD) compared with conventional therapy alone. Methods Two reviewers independently searched PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov for relevant Randomized Controlled Trials (RCTs) examining CBT for PPPD which were conducted and published in English from January 2002 to November 2022. RCTs reporting any indicators for assessing corresponding symptoms of PPPD were included, such as Dizziness Handicap Inventory (DHI), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Hospital Anxiety and Depression Scale (HADS), and Patient Health Questionnaire-9 (PHQ-9). Two independent reviewers conducted extraction of relevant information and evaluation of risk of bias. The Cochrane Collaboration risk of bias tool version 1.0 was used to evaluate risks and assess the quality of the included studies, and Cochrane Review Manager 5.3 software (RevMan 5.3) was used to perform meta-analyses. Results The results of six RCTs indicated that combining additional CBT with conventional therapy significantly improved outcomes for PPPD patients compared with conventional therapy alone, especially in DHI-Total scores (Mean Difference [MD = −8.17], 95% Confidence Interval [95% CI: −10.26, −6.09], p< 0.00001), HAMA scores (MD = −2.76, 95% CI: [−3.57, −1.94], p< 0.00001), GAD-7 scores (MD = −2.50, 95% CI [−3.29, −1.70], p< 0.00001), and PHQ-9 scores (MD = −2.29, 95% CI [−3.04, −1.55], p< 0.00001). Subgroup analysis revealed a significant benefit of additional CBT compared with conventional therapies alone, including Vestibular Rehabilitation Therapy (VRT) (MD = −8.70, 95% CI: [−12.17, −5.22], p< 0.00001), Selective Serotonin Reuptake Inhibitor (SSRI) (with controlled SSRI: MD = −10.70, 95% CI: [−14.97, −6.43], p< 0.00001), and VRT combined with SSRI (MD = −6.08, 95% CI [−9.49, −2.67], p= 0.0005) in DHI-Total scores. Conclusion Additional CBT combined with conventional therapy may provide additional improvement for patients with PPPD compared with conventional therapy alone. However, more RCTs are needed to support and guide the application of CBT in treating PPPD. Level of evidence: I; Systematic review of RCTs.

Perfil cognitivo en el Mareo Perceptual Postural Persistente: Implicancias sobre su fisiopatología como disfunción cognitiva viso-vestibular superior / Cognitive profile in Persistent Postural Perceptual Dizziness: Implications on its pathophysiology as a superior visio-vestibular cognitive dysfunction

Introducción: El mareo perceptual postural persistente (MPPP) es, probablemente, la causa más prevalente de mareo crónico. Sin embargo, su fisiopatología es aún motivo de duda y debate. En el presente artículo, proponemos que el MPPP se caracteriza por disfunciones cognitivas de orden superior, al punto de diferenciarse en estas dimensiones de controles sanos y pacientes con patologías vestibulares no-MPPP. Objetivo: Determinar si pacientes con MPPP presentan alteraciones discriminantes respecto a grupos controles, en ámbitos de atención, memoria de trabajo visoespacial, planificación espacial, funciones ejecutivas y rendimiento cognitivo global. Material y Método: Estudio descriptivo transversal con sujetos de entre 18 y 65 años, reclutados de una unidad de otoneurología ambulatoria. Se aplicaron pruebas Montreal Cognitive Assessment (MoCA), tarea de retención de dígitos, Trail Making Test, Corsi Block-Tapping Task y Torre de Londres. Resultados: 30 pacientes fueron categorizados en tres grupos: grupo MPPP (n = 14), grupo vestibular no-MPPP (n = 11) y grupo control (n = 5). El grupo MPPP exhibió un rendimiento significativamente inferior en pruebas de planificación, velocidad de procesamiento y funciones ejecutivas en ámbitos visoespaciales, mientras que en atención y memoria visoespacial no hubo diferencias entre grupos. Conclusión: El MPPP podría caracterizarse por una disfunción de procesos cognitivos superiores de construcción espacial de mayor complejidad, respetando funciones visoespaciales de menor orden como la memoria de trabajo. Estos hallazgos ofrecen nuevas luces para comprender la fisiopatología del MPPP y sus implicancias clínicas.

Introduction: Persistent postural-perceptual dizziness (PPPD) is probably the most prevalent cause of chronic dizziness. However, its pathophysiology is still a matter of uncertainty and debate. In this article, we propose that PPPD is characterized by higher-order cognitive dysfunctions, to the point of differentiating it from healthy controls and patients with non-PPPD vestibular pathologies. Aim: To determine whether patients with PPPD exhibit discriminant alterations compared to control groups in the areas of attention, visuospatial working memory, spatial planning, executive functions, and global cognitive performance. Materials and Methods: A cross-sectional descriptive study was conducted with subjects between the ages of 18 and 65 years, recruited from an outpatient otoneurology unit. Tests included the Montreal Cognitive Assessment (MoCA), digit retention task, Trail Making Test, Corsi Block-Tapping Task, and the Tower of London. Results: 30 patients were categorized into three groups: PPPD group (n = 14), non-PPPD vestibular group (n = 11), and control group (n = 5). The PPPD group showed significantly lower performance on tests of planning, processing speed, and executive function in visuospatial domains, while there were no differences between groups in attention and visuospatial memory. Conclusion: PPPD may be characterized by dysfunction of higher-order cognitive processes related to spatial construction of greater complexity, while sparing lower-order visuospatial functions such as working memory. These findings offer new insights into the pathophysiology of PPPD and its clinical implications.

Tratamento manipulativo osteopático em paciente com síndrome da pessoa rígida e miastenia gravis: relato de caso / Osteopathic manipulative treatment in person with stiff person syndrome and myasthenia gravis: case report

Introdução: Síndrome da Pessoa Rígida (SPR) é uma doença neurológica autoimune rara caracterizada pela rigidez e espasmos musculares episódicos dolorosos, especialmente no tronco e extremidades do corpo, gerando comprometimento funcional importante. Existe uma lacuna de conhecimento sobre os possíveis efeitos do tratamento manipulativo osteopático (TMO) nos sintomas motores de pessoas com SPR. Objetivos: Descrever os efeitos do TMO na tontura, equilíbrio e amplitude de movimento (ADM) cervical em uma pessoa com a SPR e miastenia gravis. Método: Relato de caso baseado no TMO em uma mulher com SPR e miastenia grave. As seguintes avaliações foram utilizadas: Inventário de Brazilian Version of the Dizziness Handicap Inventory (DHI), Fall Efficacy Scale (FES I ­ Brazil), Timed Get Up and Go Test (TUG), Teste de Sentar e Levantar 5 vezes, goniometria dos movimentos da coluna cervical. Resultados: Nenhum resultado expressivo foi obtido pela FES-I (-1,8%) e DHI (0%). Para os testes funcionais (TUG e Sentado para de pé 5 vezes) observamos melhora de 5,8% e 6,7%, respectivamente, após o tratamento. A ADM cervical melhorou substancialmente em todos os movimentos avaliados (flexão: 60%, extensão: 28%, rotação direita: 33%, rotação esquerda:38%, inclinação lateral direita: 77%, inclinação lateral esquerda: 87%). Conclusão: O TMO proposto pareceu ser importante para melhora da ADM cervical no caso relatado. Medo de quedas, impacto da tontura na qualidade de vida e funcionalidade de membros inferiores não demonstrou melhoras após o TMO.

Introduction: Stiff Person Syndrome (SPS) is a rare neurological autoimmune disease characterized by stiffness and painful episodic muscle spasms, especially in the trunk and extremities of the body, causing significant functional impairment in affected individuals. There is a gap in knowledge about the possible effects of an osteopathic manipulative treatment (OMT) on the motor symptoms of people with SPS. Objectives: To describe the effects of an OMT on dizziness, balance deficit, and cervical range of motion (ROM) in a patient with SPS and myasthenia gravis. Methods: This is a case report on an OMT intervention in a woman with SPS and myasthenia gravis. The following assessments were used: Brazilian Version of the Dizziness Handicap Inventory (DHI), Fall Efficacy Scale (FES I ­ Brazil), Timed Get Up and Go Test (TUG), Stand Up Test 5 times, goniometry of cervical movements. Results: No expressive results were obtained for FES I ­ Brazil (-1.8%) and DHI (0%). For the functional tests (TUG and Sit and stand up 5x) we observed an improvement of 5.8% and 6.7%, respectively, after treatment. The cervical ROM improved substantially in all movements tested (flexion: 60%, extension: 28%, right rotation: 33%, left rotation: 38%, right side bending: 77%, left side bending: 87%). Conclusion: The proposed OMT appears to be important for the improvement of cervical ROM in this case. Fear of falls, impact of dizziness on quality of life, and lower limb functionality did not demonstrate meaningful improvements after the OMT.

Reabilitação vestibular: sua efetividade após a alta / Vestibular rehabilitation: Its effectiveness after discharge / Rehabilitación vestibular: su efectividad después del alta

ntrodução: A reabilitação vestibular é um tratamento para tontura crônica que utiliza exercícios personalizados visando restaurar o controle postural e reduzir a tontura. Pouco se discute na literatura sobre os benefícios em longo prazo desta intervenção. Objetivos: Descrever o perfil dos pacientes atendidos no Ambulatório de Reabilitação Vestibular e verificar a melhora do equilíbrio corporal após a alta fonoaudiológica. Métodos: Foram colhidas informações acerca dos dados sociodemográficos, diagnóstico, tratamento anterior e queixas existentes. As informações foram obtidas por contato telefônico e acesso aos prontuários. Os dados foram analisados estatisticamente utilizando nível de significância de 5%. Resultados: Participaram 26 indivíduos, sendo 21 (80,8%) do gênero feminino, com média de idade de 67 anos. A queixa principal foi tontura não rotatória. O resultado do teste vestibular mais comum foi hipofunção vestibular unilateral. Dentre os entrevistados, 25 (96,2%) relataram melhora dos sintomas com o tratamento, com redução da pontuação obtida no Dizziness Handicap Inventory. Sete participantes (26,9%) permaneceram assintomáticos desde o término da reabilitação. Aqueles que relataram ainda sentirem tontura, descreveram que esta possui menor intensidade que no período anterior à intervenção.Conclusão: Houve prevalência de indivíduos do gênero feminino, idosos, com ensino fundamental incompleto, sem diagnóstico otoneurológico estabelecido, com queixa de tontura não rotatória e resultado do teste vestibular de hipofunção vestibular unilateral.A reabilitação vestibular foi eficaz para redução dos sintomas apresentados. A exposição sucessiva aos exercícios após o tratamento auxilia na manutenção do equilíbrio. Contudo, a adesão à realização dos exercícios após a alta ainda é baixa. (AU)

Introduction: Vestibular rehabilitation is a treatment for chronic dizziness that uses personalized exercises aimed at restoring postural control and reducing dizziness. There is little discussion in the literature about the long-term benefits of this intervention. Objectives: To describe the profile of patients seen at the Vestibular Rehabilitation Outpatient Clinic and verify body balance improvement after speech-language-hearing therapy discharge. Methods: Sociodemographic data, diagnosis, previous treatment, and existing complaints were collected. The information was obtained via phone calls and medical records. The data were statistically analyzed using a significance level of 5%. Results: 26 individuals participated, of whom 21 (80.8%) were female, with a mean age of 67 years. The main complaint was non-rotational dizziness. The most common vestibular test result was unilateral vestibular hypofunction. Among the interviewees, 25 (96.2%) reported improved symptoms after the treatment, with reduced Dizziness Handicap Inventory scores. Seven participants (26.9%) remained asymptomatic since the end of rehabilitation. Those who still reported dizziness described it as less intense than before the intervention. Conclusion: There was a prevalence of females, older adults with incomplete middle school, no established otoneurological diagnosis, complaint of non-rotational dizziness, and vestibular test results of unilateral vestibular hypofunction. Vestibular rehabilitation effectively reduced the symptoms. Successive exposure to exercises after treatment helps maintain balance. However, adherence to exercise after discharge is still low. (AU)

Introducción: La rehabilitación vestibular es un tratamiento para la vértigo crónico que utiliza ejercicios personalizados con el objetivo de restaurar el control postural y reducir el vértigo. Hay poco debate en la literatura sobre los beneficios a largo plazo de esta intervención. Objetivos: Describir el perfil de los pacientes atendidos en el Ambulatorio de Rehabilitación Vestibular y verificar la mejora del equilibrio corporal después del alta fonoaudiológica. Métodos: Se recopilaron información sobre datos sociodemográficos, diagnóstico, tratamiento previo y quejas que aún persistían. La información se obtuvo por contacto telefónico y acceso a los registros médicos. Los datos se analizaron estadísticamente utilizando un nivel de significación del 5%. Resultados: Participaron 26 individuos, siendo 21 (80,8%) del género femenino, con una edad promedio de 67 años. La queja principal fue vértigo no rotatorio. El resultado del examen vestibular más común fue hipofunción vestibular unilateral. Entre los entrevistados, 25 (96,2%) informaron una mejora en los síntomas con el tratamiento, con una reducción en la puntuación obtenida en el Dizziness Handicap Inventory. Siete participantes (26,9%) permanecieron asintomáticos desde el final de la rehabilitación. Aquellos que informaron que todavía experimentaban vértigo describieron que este tenía una intensidad menor que en el período anterior a la intervención. Conclusión: Hubo una prevalencia de individuos del género femenino, ancianos, con educación primaria incompleta, sin un diagnóstico otoneurológico establecido, con queja de vértigo no rotatorio y un resultado del examen vestibular de hipofunción vestibular unilateral. La rehabilitación vestibular fue efectiva para reducir los síntomas presentados. La exposición sucesiva a los ejercicios después del tratamiento ayuda a mantener el equilibrio. Sin embargo, la adherencia a la realización de los ejercicios después del alta sigue siendo baja. (AU)

Comparação do nível de confiança para realização de atividades diárias pré e pós reabilitação vestibular em pacientes com disfunção vestibular / Comparison of the level of confidence to perform daily activities before and after vestibular rehabilitation in patients with vestibular dysfunction / Comparación del nivel de confianza para la realización de actividades diarias antes y después de la rehabilitación vestibular en pacientes con disfunción vestibular

Introdução: A reabilitação vestibular (RV) surge como uma opção terapêutica em casos de tontura e desequilíbrio postural. O The Activities-specific Balance Confidence Scale (ABC Scale) é um questionário utilizado para avaliar a interferência destes sintomas vestibulares por meio do nível de confiança dos indivíduos em realizar atividades diárias que envolvem o equilíbrio postural. Objetivo: comparar o nível de confiança na realização de atividades diárias relacionadas ao equilíbrio corporal, pré e pós reabilitação vestibular (RV) em pacientes com disfunção vestibular. Método: Estudo primário, intervencional, clínico, longitudinal, prospectivo, analítico, não controlado. Participaram 14 indivíduos, do sexo feminino e masculino, portadores de vestibulopatia periférica. Foi aplicado o Activities-specific Balance Confidance Scale (ABC Scale) nas condições pré e pós RV. Os dados foram analisados de forma descritiva e inferencial, pelos testes Exato de Fisher, t-Sudent e o modelo linear de efeitos mistos. Resultados: A amostra se caracterizou por 78.57% do sexo feminino e 21.43% do sexo masculino, com média de idade de 59.21 anos. Observou-se diferença estatística quando comparados os resultados do ABC Scale nas condições pré e pós RV (p<0.0001). Não foi verificada diferença estatística entre os escores deste instrumento com as variáveis sexo, idade e número de sessões terapêuticas. Conclusão: Foi possível concluir que o nível de confiança dos pacientes dessa amostra modificou de baixo, na fase pré reabilitação, para alto, na fase final da intervenção, o que consolida a ocorrência do aumento no nível de confiança que acarretou melhoria na qualidade de vida. (AU)

Introduction: Vestibular rehabilitation (VR) appears as a therapeutic option in cases of dizziness and postural imbalance. The Activities-specific Balance Confidence Scale (ABC Scale) is a questionnaire used to assess the interference of these vestibular symptoms with the individuals' level of confidence to carry out daily activities involving postural balance. Objective: to compare the level of confidence to carry out daily activities related to body balance, before and after VR, in patients with vestibular dysfunction. Method: Primary, interventional, clinical, longitudinal, prospective, analytical, and noncontrolled study. The sample comprised 14 male and female individuals with peripheral vestibulopathy. The ABC Scale was applied before and after VR. Descriptive and inferential data analysis were performed, using Fisher's Exact test, Student's t-test, and the linear mixed-effects model. Results: The sample had 78.57% females and 21.43% males, with a mean age of 59.21 years. There was a statistical difference in ABC Scale results before and after VR (p < 0.0001). There was no statistical difference between its scores and sex, age, or the number of therapy sessions. Conclusion: It was concluded that this study patients' confidence level changed from low in the pre-rehabilitation phase, to high in the final phase of the intervention, which consolidates the increase in confidence level that led to an improvement of quality of life. (AU)

Introducción: La rehabilitación vestibular (RV) aparece como una opción terapéutica en casos de mareos y desequilibrio postural. La Escala de Confianza en el Equilibrio Específica de Actividades (Escala ABC) es un cuestionario utilizado para evaluar la interferencia de estos síntomas vestibulares a través del nivel de confianza de los individuos en la realización de actividades diarias que involucran el equilibrio postural. Objetivo: comparar el nivel de confianza en la realización de actividades cotidianas relacionadas con el equilibrio corporal, pre y post rehabilitación vestibular (RV) en pacientes con disfunción vestibular. Método: Estudio primario, intervencionista, clínico, longitudinal, prospectivo, analítico, no controlado. Participaron 14 individuos, hombres y mujeres y con vestibulopatía periférica. La Escala de Confianza del Equilibrio Específica de Actividades (Escala ABC) se aplicó en condiciones previas y posteriores a la RV. Los datos fueron sometidos a análisis descriptivo e inferencial mediante la prueba exacta de Fisher, t-Sudent y el modelo lineal de efectos mixtos. Resultados: La muestra se caracterizó por 78,57% del sexo femenino y 21,43% del masculino, con una edad media de 59,21 años. Hubo diferencia estadística al comparar los resultados de la Escala ABC en condiciones pre y post RV (p<0,0001). No hubo diferencia estadística entre los puntajes de este instrumento con las variables sexo, edad y número de sesiones terapéuticas. Conclusión: Fue posible concluir que el nivel de confianza de los pacientes de esta muestra pasó de bajo, en la fase de pre-rehabilitación, a alto, en la fase final de la intervención, lo que consolida la ocurrencia del aumento en el nivel de confianza que llevó a una mejora en la calidad de vida. (AU)

Habilidades cognitivas em idosos com disfunção vestibular submetidos à reabilitação vestibular ­ estudo piloto / Cognitive skills in older people with vestibular dysfunction undergoing vestibular rehabilitation ­ A pilot study / Habilidades cognitivas en ancianos con disfunción vestibular en rehabilitación vestibular ­ estudio piloto

Introdução: estudos relatam melhora de habilidades cognitivas após a reabilitação vestibular, porém estes estudos utilizaram testes de rastreio cognitivo ou avaliaram habilidades cognitivas específicas, não contemplando uma avaliação cognitiva detalhada. Objetivo: avaliar as habilidades cognitivas, sintomas depressivos, funcionalidade e aspectos sociodemográficos de idosos com disfunção vestibular antes e após a reabilitação vestibular. Método: estudo longitudinal, quase experimental e analítico. A casuística foi composta por 11 idosos com idade entre 60 e 89 anos, ambos os sexos, todos com disfunção vestibular comprovada por meio dos exames VEMP e/ou v-HIT. Os participantes foram submetidos à avaliação cognitiva, da funcionalidade e dos sintomas depressivos antes e após oito sessões semanais de RV.Resultados: encontrou-se associação entre o MEEM com a escolaridade e com o DHI; o questionário de Pfeffer correlacionou-se com o DHI; a GDS-15 com a EVA e a EEB. Após a RV observou-se melhora do ganho do canal semicircular anterior direito, da EVA, do DHI e suas subescalas físico, funcional e emocional; GDS-15, Neupsilin total e suas subescalas percepção, memória e praxia. Conclusão: após a reabilitação vestibular houve aumento do ganho do reflexo vestíbulo-ocular, diminuição dos impactos causados pela tontura na qualidade de vida e do sofrimento psicológico, além da melhora da função cognitiva geral e das habilidades de percepção, memória e praxia.(AU)

Introduction: Studies have reported improved cognitive skills after vestibular rehabilitation (VR). However, they used cognitive screening tests or other ones that assess specific cognitive skills, not assessing cognition in detail. Objective: To assess cognitive skills, depressive symptoms, functioning, and sociodemographic aspects in older adults with vestibular dysfunction before and after vestibular rehabilitation. Method: Longitudinal, analytical, quasi-experimental study. The sample had 11 older adults aged 60 to 89 years, of both sexes, all of them with vestibular dysfunction verified with VEMP and/or vHIT examination. Participants were submitted to cognitive, functioning, and depressive symptoms assessment before and after eight weekly VR sessions. Results: MMSE was associated with educational attainment and DHI; the Pfeffer questionnaire was correlated with DHI; GDS-15 was correlated with VAS and BBS. After VR, there were improvements in gain in the right anterior semicircular canal, VAS, DHI and its physical, functional, and emotional subscales, GDS-15, and Neupsilin total score and its perception, memory, and praxis subscales. Conclusion: After VR, the vestibulo-ocular reflex gain increased, the impacts of dizziness on the quality of life and the psychological suffering decreased, and the overall cognitive function and perception, memory, and praxis skills improved. (AU)

Introducción: los estudios informan mejoría en las habilidades cognitivas después de la rehabilitación vestibular, pero estos estudios utilizaron pruebas de detección cognitiva o evaluaron habilidades cognitivas específicas, no contemplando una evaluación cognitiva detallada. Objetivo: evaluar habilidades cognitivas, síntomas depresivos, funcionalidad y aspectos sociodemográficos de ancianos con disfunción vestibular antes y después de la rehabilitación vestibular. Método: estudio longitudinal, cuasi-experimental y analítico. La casuística estuvo constituida por 11 ancianos con edades entre 60 y 89 años, de ambos sexos, todos con disfunción vestibular comprobada mediante exámenes VEMP y/o v-HIT. Los participantes se sometieron a una evaluación de síntomas cognitivos, funcionales y depresivos antes y después de ocho sesiones semanales de rehabilitación vestibular. Resultados: se encontró asociación entre el MMSE con la educación y con el DHI; el cuestionario de Pfeffer correlacionó con el DHI; el GDS-15 con el EVA y el EEB. Después de la RV, hubo una mejora en la ganancia del canal semicircular anterior derecho, la EVA, el DHI y sus subescalas física, funcional y emocional; GDS-15, Neupsilina total y sus subescalas percepción, memoria y praxis. Conclusión: después de la rehabilitación vestibular, hubo aumento en la ganancia del reflejo vestíbulo-ocular, disminución de los impactos causados por el mareo en la calidad de vida y el sufrimiento psicológico, mejoría en la función cognitiva general y en las habilidades de percepción, memoria y praxis. (AU)

Vértigo en gestantes: presentación clínica, impacto en la calidad de vida y factores asociados / Vertigo in pregnancy: clinical presentation, impact on quality of life and associated factors

OBJETIVO: Evaluar las características clínicas, el impacto en la calidad de vida y los factores asociados con vértigo en gestantes hospitalizadas en una institución de alta complejidad. MÉTODO: Estudio transversal. Se realizó una encuesta dirigida a la presencia de vértigo y sus características clínicas en 2020-2021. La calidad de vida se evaluó con el cuestionario Dizziness Handicap Inventory (DHI). El análisis estadístico incluyó un modelo lineal generalizado. RESULTADOS: De 103 mujeres, el 19,4% indicaron vértigo principalmente en el segundo trimestre de gestación (60%), con una mediana de 3,5 (rango intercuartil: 1,5-7,5) episodios. Fueron referidos vértigos episódicos asociados con cambios posicionales (40%), acompañados de inestabilidad (60%), cefalea (60%), fotopsias (55%) y tinnitus (45%). Las mujeres con vértigo presentaron mayor frecuencia de discapacidad moderada a grave en las dimensiones del DHI emocional (30 vs. 2,4%; p = 0,001), funcional (40 vs. 2,4%; p < 0,001) y física (55 vs. 2,4%; p < 0,001) en comparación con las mujeres sin la patología. La hospitalización durante el embarazo Razón de proporción (RP): 4,02; intervalo de confianza del 95% [IC95%]: 1,64-9,85; p = 0,002) y la presencia de vértigo pregestacional (RP: 2,37; IC95%: 1,15-4,88; p = 0,019) se identificaron como factores asociados. CONCLUSIONES: La alta frecuencia de vértigo en las gestantes sugiere la importancia de estudiar esta condición durante el embarazo, para lograr un manejo integral y generar acciones de prevención y control efectivas.

OBJECTIVE: To evaluate clinical characteristics, impact on quality of life and factors associated with vertigo in pregnant women hospitalized in a highly complex institution. METHOD: A cross-sectional study was conducted in 2021-2022. One focused survey including Dizziness Handicap Inventory (DHI) was performed. The statistical analysis was performed using a generalized lineal regression. RESULTS: 103 patients were included, 19.4% indicated vertigo mostly during the second semester (60%). A median of 3.5 episodes was obtained (RIC: 1.5-7.5). Positional and episodic vertigos (40%) associated with unsteadiness (60%), headache (60%), photopsia (55%) and tinnitus (45%) were described. DHI in pregnant females with vertigo compared to those without vertigo, presented higher rates of moderate to severe disability in the emotional (30 vs. 2.4%: p = 0.001), functional (40 vs. 2.4%; p < 0.001) and physical (55 vs. 2.4%; p < 0.001) dimensions. Hospitalizations during the pregnancy (RP: 4.02; 95%CI: 1.64-9.85; p = 0.002) and previous episodes before pregnancy (RP: 2.37; 95%CI: 1.15-4.88; p = 0.019) were identified as associated factors with current vertigo episodes. CONCLUSIONS: The high frequency of vertigo in pregnant women suggests the importance of studying this condition during pregnancy, to achieve comprehensive management and generate effective prevention and control actions.

Fisioterapia vestibular na síndrome de Arnold-Chiari com uso da Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF): relato de caso / Vestibular physiotherapy in Arnold-Chiari syndrome using the International Classification of Functioning, Disability and Health (ICF): case report

Objetivo: Investigar os efeitos de um protocolo de Fisioterapia Vestibular (FV), baseado no modelo da Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF) em um paciente com sequelas da síndrome de Arnold-Chiari do tipo I nas queixas de tontura, alterações oculomotoras, desequilíbrio e impacto da tontura na qualidade de vida. Método: Trata-se da descrição do caso de um paciente de 40 anos que realizou um protocolo de FV em 44 sessões, uma a duas vezes por semana, envolvendo exercícios de estabilização do olhar, oculomotores, habituação, equilíbrio estático e dinâmico, tanto em ambiente clínico presencial, quanto remoto e domiciliar. Foram realizadas avaliações da intensidade da tontura e desequilíbrio, do sistema oculomotor, do equilíbrio estático e dinâmico, bem como da qualidade de vida. As informações coletadas na avaliação inicial foram convertidas para os domínios da CIF. Resultados: Houve redução no relato da intensidade da tontura e desequilíbrio, na distância do ponto próximo de convergência, melhora no equilíbrio postural estático e início da prática de atividade física regular, porém manteve o risco de queda no teste de equilíbrio dinâmico e deficiência grave quanto à qualidade de vida. Conclusão: O protocolo de FV, planejado a partir do uso da CIF, mostrou resultados positivos quanto à intensidade da queixa de tontura e desequilíbrio, convergência ocular e equilíbrio estático, com manutenção dos resultados quanto ao equilíbrio dinâmico e à qualidade de vida em um paciente com sequelas da síndrome de Arnold-Chiari. Os resultados deste estudo podem direcionar a conduta clínica e pesquisas futuras relacionadas a esta população

Objective: To investigate the effects of a Vestibular Physiotherapy (VP) protocol, according to the International Classification of Functioning, Disability and Health (ICF) model, in a patient with Arnold-Chiari syndrome type I sequelae on complaints of dizziness, oculomotor disorders, imbalance and the impact of dizziness on quality of life. Method: This is the case description of a 40-year-old patient who underwent a VP protocol into 44 sessions, up to twice a week. The protocol involved eye stabilization, oculomotor, habituation, static and dynamic balance exercises, which were performed through face-to-face clinical setting, remote assistance and home-based exercises. Assessments of the intensity of dizziness and imbalance, oculomotor system, static and dynamic balance and the impact of dizziness on quality of life were performed. The information collected in the initial assessment was converted into the ICF domains. Results: There was a reduction in the report of the intensity of dizziness and imbalance, in the distance from the near point of convergence, improvement in static postural balance, and started the practice of physical activities. However, the risk of falling was maintained in the dynamic balance test and also severe impairment on quality of life. Conclusions: The VP protocol, planned according to ICF, demonstrated positive results regarding the intensity of dizziness and imbalance, ocular convergence and static balance, with maintenance of the results regarding dynamic balance and quality of life in a patient with sequelae of Arnold-Chiari syndrome. The results of this study may guide clinical management and future research related to this population

Research progress in pathogenesis of white matter hyperintensity related dizziness in small cerebral vascular disease / 中国综合临床

With the development of neuroimaging technology, cerebral small vessel disease has become a hot research topic in recent years. It has been clearly related to cognitive decline, dementia and gait instability. However, recent studies have found that small cerebral vascular disease with white matter hyperintensities is the main cause of chronic dizziness in the elderly, but the pathogenesis is not completely clear, which may be related to brain neural network disconnection, visual dependence, eye movement disorder caused by abnormal brain tissue structure, oxidative stress regulation disorder, cerebral blood flow self-regulation disorder, and the interaction mechanism between vestibular system and emotional disorder.

Analysis of the characteristics of eye movement changes in patients with acute cerebral infarction characterized by dizziness or vertigo / 中国医师进修杂志

Objective:To analyze the characteristics of eye movement changes in patients with acute cerebral infarction characterized by dizziness or vertigo.Methods:The clinical data of 114 patients characterized by dizziness or vertigo in the Civil Aviation General Hospital from January 2021 to June 2022 were retrospectively analyzed. Among them, acute cerebral infarction was in 74 cases (acute cerebral infarction group), including anterior circulation infarction 32 cases, posterior circulation infarction 42 cases; benign paroxysmal positional vertigo (BPPV) was in 40 cases (BPPV group). The clinical manifestation and the results of videonystagmography (VNG) examination were recorded.Results:There were no statistical differences in the incidences of visual shaking, dysarthria and paresthesia between two groups ( P>0.05); the incidence of visual rotation in acute cerebral infarction group was significantly lower than that in BPPV group: 25.68% (19/74) vs. 100.00% (40/40), the incidence of limb weakness and walking instability were significantly higher than those in BPPV group: 29.73% (22/74) vs. 0 and 39.19% (29/74) vs. 0, and there were statistical differences ( P<0.01). The result of VNG examination showed that the abnormal incidences of eye movement and positional test in acute cerebral infarction group were significantly lower than those in BPPV group: 74.32% (55/74) vs. 100.00% (40/40) and 2.70% (2/74) vs. 100.00% (40/40), the abnormal incidences of gaze-holding test, without fixation test, randomly saccade test, smooth pursuit test and optokinetic nystagmus test were significantly higher than those in BPPV group: 10.81% (8/74) vs. 0, 21.62% (16/74) vs. 0, 45.95% (34/74) vs. 2.50% (1/40), 60.81% (45/74) vs. 5.00% (2/40) and 21.62% (16/74) vs. 0, and there were statistical differences ( P<0.01 or <0.05). There were no statistical differences in the incidences of visual rotation, visual shaking, dysarthria, walking instability and paresthesia between anterior circulation infarction patients and posterior circulation infarction patients ( P>0.05); the incidence of limb weakness in patients with anterior circulation infarction was significantly higher than that in patients with posterior circulation infarction: 50.00% (16/32) vs. 14.29% (6/42), and there was statistical difference ( P<0.01). The result of VNG examination showed there were no statistical differences in the abnormal incidences of eye movement, gaze-holding test, without fixation test, randomly saccade test, smooth pursuit test, optokinetic nystagmus test and position test between anterior circulation infarction patients and posterior circulation infarction patients ( P>0.05). Conclusions:The abnormal incidence of eye movements in patients with acute cerebral infarction is relatively high, and VNG examination can help reflect changes of the eye movement pathway in the brain.

Review：thoughts and methods for the diagnosis and treatment of chronic dizziness / 中风与神经疾病杂志

@#Chronic dizziness is a common clinical symptom with a complex etiology. With the updating of concepts and technological development in the diagnosis and treatment of dizziness and vertigo，the understanding of chronic dizziness diseases is also constantly improving. Diagnostic standards for some common diseases have been published，and treatment methods supported by evidence-based medicine have been applied in clinical practice. This article takes the concept of chronic dizziness as a starting point，sorts out its underlying pathophysiological mechanisms and common causes，and attempts to establish an effective set of thoughts and methods for the diagnosis and treatment of chronic dizziness. It aims to make a preliminary exploration to improve the diagnosis and treatment level of dizziness diseases.

Cerebral blood flow dysautoregulation and idiopathic orthostatic dizziness/vertigo in the elderly / 中风与神经疾病杂志

@#Orthostatic dizziness is a common type of dizziness or vertigo in the department of neurology. In the past，there was no expert consensus or diagnosis and treatment guideline for this disease due to the lack of diagnostic methods and standards. Based on the international criteria published by the Committee for the Classification of Vestibular Disorders of the Bárány Society in 2019 as well as our clinical experience，this article focuses on the possible mechanisms and diagnosis and treatment suggestions on orthostatic dizziness/vertigo in the elderly，hoping to provide a reference for clinicians.

Research progress in vascular dizziness/vertigo based on CiteSpace visual analysis / 中风与神经疾病杂志

@#Objective To explore the research hotspots and development trend on vascular dizziness/vertigo based on visual analysis. Methods The Web of Science Core Collection Database was searched for papers on vascular dizziness/vertigo from January 2008 to March 2023. The CiteSpace 6.2.R2 software was used for visual analysis of the literature. Results There were a total of 1298 papers，with an increasing number of published papers from January 2008 to March 2023. A total of 424 institutions from 83 countries/regions had published relevant papers. The United States ranked first in terms of the number of published papers（331 papers） and betweenness centrality（0.25）. Johns Hopkins University was the number one institution in terms of the number of published papers （56 papers），Newman-toker and David E were the most prolific authors. The most common keyword was ischemic stroke. According to keyword clustering，research in this field focused on early diagnosis of vascular dizziness/vertigo from risk factors and bedside examinations and infarction of the anterior inferior cerebellar artery supply area. In recent years，researchers had more interests in case reports，video electronystagmograms，and pathophysiological mechanisms in this field. Conclusion There are growing international studies on vascular dizziness/vertigo. Early diagnosis of vascular dizziness/vertigo through risk factors and bedside examinations in the emergency room is a research hotspot in this field. Researchers should focus on these topics in future studies.

Neuroimaging research status of persistent postural-perceptual dizziness / 中风与神经疾病杂志

@#Persistent postural-perceptual dizziness （PPPD） is a common clinical chronic dizziness disease，with persistent dizziness，instability，or non-rotational vertigo as the main symptom. It may be aggravated by postural changes，active/passive movements，and exposure to complex visual environments. At present，it is believed that the occurrence of PPPD may be related to the failure of postural control readaptation and abnormal cortical multisensory integration，but the specific pathophysiological mechanism is not clear. In recent years，with the continuous application of neuroimaging technology in the field of vertigo diseases，it has been found that in patients with PPPD，the brain structure，function，and connectivity related to vestibular multisensory and spatial orientation are decreased，while the function and connectivity related to visual processing are enhanced. At the same time，various psychiatric factors （such as anxiety，depression，and neuroticism） as well as triggers may be involved in regulating the brain structure of people with PPPD，which helps explain the differences in outcomes between studies. The above neuroimaging findings are helpful for the early diagnosis and treatment of PPPD. Therefore，this paper reviews the neuroimaging studies of PPPD to provide a reference for explaining the pathophysiological mechanism of PPPD.

Research advances in relationship between dizziness/vertigo and anxiety and depression / 中风与神经疾病杂志

@#Dizziness and vertigo are a major burden for the general population. Dizziness is a non-motion sensation of spatial disorientation，while vertigo is a false or distorted sensation of motion. Unlike vertigo，dizziness does not present with the typical sense of spinning，moving，rising，or falling. In a broad sense，dizziness includes vertigo. Anxiety and depression，public health burdens，are closely correlated negative states of cognition of self，environment，and future. Studies have shown that patients with dizziness/vertigo are at higher risk for a variety of psychiatric disorders，especially anxiety and depression. Anxiety and depression greatly affect the prognosis and burden of patients with dizziness/vertigo，who often report multiple somatic symptoms. This paper reviews domestic and international research on the association of dizziness/vertigo with anxiety and depression.

An analysis of factors associated with conversion from BPPV with residual dizziness to PPPD / 中风与神经疾病杂志

@#Objective To analyze the factors influencing the duration of residual dizziness （RD） after successful repositioning in patients with benign paroxysmal positional vertigo （BPPV） and the factors affecting the conversion from BPPV to persistent postural-perceptual dizziness（PPPD）. Methods A total of 575 patients with BPPV with successful repositioning at Shaanxi Provincial People's Hospital from January 2021 to 2022 were enrolled. Among them， 273 patients had RD， which lasted ≤1 week in 116 cases， 1 week to 3 months in 104 cases， and ≥3 months in 53 cases. Among the patients with RD ≥3 months， PPPD was negative in 32 cases and positive in 21 cases. The risk factors for RD converting into PPPD were analyzed. Results The incidence of RD in BPPV was 47.5%. Of the patients with RD，42.5% had a complete recovery within a week， but still 19.4% continued to experience RD for more than three months， which turned into PPPD. Anxiety-depressive state was an independent risk factor for BPPV converting into PPPD（OR=8.148，P=0.011）. Abnormal blood pressure was significantly association with the conversion of BPPV with RD into PPPD（P<0.05）. Conclusion For the conversion of BPPV with RD into PPPD， anxiety-depressive state was an independent risk factor， and abnormal blood pressure levels were an associated risk factor.

Study on the influence of Barbecure combined with Epley on residual dizziness of horizontal canal benign paroxysmal positional vertigo by SRM-vertigo diagnosis system / 临床耳鼻咽喉头颈外科杂志

Objective:To investigate the influence of Barbecure combined with Epley on residual dizziness of horizontal canal benign paroxysmal positional vertigo（HC-BPPV） by SRM-vertigo diagnosis system. Methods:A total of 406 patients diagnosed with HC-BPPV from Nov 2021 to Nov 2022 were enrolled by rapid axial roll test and Dix-Hallpike in the department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Xi'an Jiaotong University. The patients were divided into two groups by hospital card numbers, in which the numbers that were odd were considered as group A, and the numbers that were even were considered as group B. The group A underwent two circles of Barbecure repositioning procedure by SRM-vertigo diagnosis system, while the group B underwent two circles Barbecure combined with Epley repositioning procedure by SRM-vertigo diagnosis system. The treatment was stopped on the next day when two groups of patients were cured, and those who were not cured will continue treatment with the same method. Results:The cure rate of group A was 83.41%, and the cure rate of group B was 80.51%, the difference between the two groups was not-statistically significant difference（P>0.05）. The rate of residual dizziness of group A was 23.30%, the rate of residual dizziness of group B was 11.46%, the difference between the two groups was statistically significant（P<0.05）. Conclusion:The Barbecure combined with Epley otoliths repositioning maneuver by SRM-vertigo diagnosis system can significantly reduce the rate of residual dizziness after the treatment of HC-BPPV, and improve the quality of life of patients.