1.
Chinese Pharmacological Bulletin
;
(12)1987.
Artículo
en Chino
| WPRIM
| ID: wpr-562887
RESUMEN
Arylamine N-acetyltransferase(NATs)is one of phase Ⅱ drug-metabolizing enzymes,which is very important in drug metabolizing and detoxification.It may become a new target for studying pharmacological effects.The study on NATs is hitherto its crystal structure or polymorphisms among different species,different ethnicity,same species,and same ethnicity.However,the study on its physiological and pharmacological effects is unwontedly reported.In the paper the research work on NATs is summarized from the following aspects:the structure,carcinogenic mechanism,endogenous activities,inhibitor,substitute products,metabolic kinetics,polymorphism and relation with diseases,and detected methods of NATs.