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Objective To study the spectrum of upper gastrointestinal diseases and infection rate of Helicobacter pylori(Hp) in our hospital during the past 35 years.Methods Patients who were 16 or older with duodenal ulcer,gastric ulcer,reflux esophagitis,gastric cancer and esophageal cancer diagnosed by gastroscopy and pathology were retrospectively enrolled in our study from January 1980 to December 2014.Patients with chronic superficial gastritis,chronic atrophic gastritis or Hp infection from January 1989to December 2014 were also included in our study according to the same diagnostic criteria.The incidences of diseases and the infection rates of Hp were studied.Results A total of 213 495 patients underwent gastroscopy in our department during the past 35 years.The overall diagnostic rates of duodenal ulcer,gastric ulcer,reflux esophagitis,gastric cancer and esophageal cancer were 9.87％,3.79％,6.66％,1.59％ and 0.66％ respectively.There were 183 426 patients receiving gastroscopy in our department from January 1989to December 2014.The overall endoscopic diagnosis rates of chronic superficial gastritis and chronic atrophic gastritis were 49.83％ and 22.43％ respectively.The overall infection rate of Hp was 36.18％,which had a declining trend consistent with peptic ulcer (all P =0.000).Yet,the prevalence of reflux esophagitis,chronic superficial gastritis and chronic atrophic gastritis were increasing (all P =0.000).The diagnostic rates of gastric cancer and esophageal cancer were persistent (P =0.266,P =0.156).Conclusions The Hp infection during years has been decreasing,consistent with the declining tendency of peptic ulcer.On the other hand,reflux esophagitis,chronic superficial gastritis and chronic atrophic gastritis show an ascendant trend.The proportion of patients with gastric cancer and esophageal cancer is relatively stable.
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Objetivo: Describir las características epidemiológicas de los sujetos con enfermedad ácido-péptica en un centro diagnóstico de primer nivel entre los años 1993 y 2007. Métodos: Estudio descriptivo retrospectivo analítico de series de pacientes. Resultados: Se incluyeron 12.638 registros de pacientes de 44,0 ± 16 años, 62,3% mujeres y 37,7% hombres. Los principales hallazgos fueron: esofagitis péptica 14,1%, úlcera gástrica 4,1%, úlcera duodenal 7,0% y duodenitis erosivas en el 10%. Entre las úlceras gástricas, las corporales fueron el 56,4% y las lesiones erosivas gástricas representaron el 21% de los casos. Solo la enfermedad ácido péptica duodenal redujo significativamente su frecuencia en el periodo examinado asociado al consumo aumentado de medicamentos inhibidores de la bomba de protones. Ninguna lesión presentó variación estacional. Conclusiones: 1. La enfermedad ácido péptica es frecuente en centros de diagnóstico médico de primer nivel, predominando en los varones. 2. La enfermedad ácido péptica duodenal presenta una reducción significativa en los últimos 14 años, probablemente asociado al mayor consumo de inhibidores de bomba de protones. 3. Se requieren estudios multicéntricos para corroborar los hallazgos descritos.
Objective: To describe epidemiological characteristics of individuals suffering from acid peptic disease found by a first level endoscopic diagnostic center from 1993 and 2007. Methods: A retrospective, descriptive and analytical study of series of patients. Results: 12,638 registers were included in the study. 62.3% of the patients women, 37.7% were men (mean 44.0 ± 16 years). Main endoscopy findings: peptic esophagitis 14.1%, gastric ulcer 4.1%, duodenal ulcer 7.0%, total acid peptic duodenal lesions 17%. Corporal gastric ulcers were most common (56.4%). Erosive gastric lesions represented 21% of cases. Only the frequency of duodenal acid peptic disease decreased significantly in the period observed. This was associated with increased consumption of proton pump inhibitors. No seasonal variation was observed in any of the lesions. Conclusions: 1. Acid peptic disease is frequently observed at the first level endoscopic center, most frequently in men. 2. We described a significant reduction in the frequency of duodenal acid peptic disease associated with increased consumption of proton pump inhibitors. 3. It is necessary to realize multi-centric studies to confirm our results.