RESUMEN
Pulmonary heart disease (PHD) is a common cardiovascular disease in China, with high mortality ratein its late stage.Currently, PHD treatments are mainly to delay the disease progression, which cannot effectively improve and cure the disease.Consequently, it is in urgent need to find a new treatment for PHD.Epigenetic regulation plays an important role in the occurrence and pathological process of diseases, which provides a novel idea of developing new drugs by regulating non-coding RNA(ncRNA).However, ncRNA studies in PHD are at the stage of few and shallow, stray and scattered.Therefore, this review for the first time summarizes ncRNA related to various PHD phenotypes, and discusses the epigenetic regulation in PHD by ncRNA.
RESUMEN
Systemic lupus erythematosus (SLE) is an autoimmune disease with various clinical manifestations and complex pathogenesis, characterized by loss of immune tolerance to autoantigens and production of large amounts of autoantibodies. Interferon (I F N) signaling pathway is one of the pathogenetic pathways widely recognized at present. In recent years, the correlation between IFN signaling and epigenetic modification in the occurrence and development of SLE has beena research hotspot. And in this paper, the relevant studies are reviewed in order to provide new research ideas for the pathogenesis of SLE.