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To study the effects of some new facilitators on the vegetative and morphological traits of Thymus kotschyanus, nine treatments were tested in the experimental rangeland field at the University of Mohaghegh Ardabili, Ardabil, Iran. Treatments included control, potassium silicate nanoparticles (PSN) with two levels of 500 and 1000 mg/lit, superabsorbent hydrogel (SH) with two levels of 10 and 30 g/kg, animal manure (AM) with two levels of 100, 200 g/kg, and effective microorganisms (EM) with two levels of 1 and 2%. Data were subjected to one-way analysis of variance (ANOVA). Results of mean comparisons of treatments for Thymus kotschyanus characteristics showed that the highest amount of studied traits were observed in the treated SH 30 g/kg. These traits include plant height (19.44 cm), basal area (4.66 cm), canopy cover (99.11%), number of secondary branches (9.44) and depth of rooting (16.49 cm), aerial parts volume (26.77 cm3), root volume (17.66 cm3), aerial parts fresh weight (14.40 g), aerial parts dry weight (7.18 g), root fresh weight (3.98 g), and root dry weight (2.07 g). In general, the impact of treatments on Thymus growth traits were ranked as follows: SH 30 g/kg, PSN 1000 mg/lit, AM 200 g/kg, SH 10 g/kg, PSN 500 mg/lit, AM 100 g/kg, EM 2%, and EM 1%. In addition,the lowest plant traits were found in control. Overall, it is recommended extending the cultivation of this native medicinal plant by considering ecological conditions in each region. In addition, to promote the establishment and facilitate the growth of planted species, it is recommended using the facilitators utilized in the present work.
Para estudar os efeitos de alguns novos facilitadores sobre as características vegetativas e morfológicas de Thymus kotschyanus L., nove tratamentos foram testados no campo experimental de pastagens na Universidade de Mohaghegh Ardabili, Ardabil, Irã. Os tratamentos incluíram controle, nanopartículas de silicato de potássio (PSN) com dois níveis de 500 e 1000 mg/L, hidrogel superabsorvente (SH) com dois níveis de 10 e 30 g/kg, esterco animal (AM) com dois níveis de 100 e 200 g/kg e microorganismos efetivos (EM) com dois níveis de 1 e 2%. Os dados foram submetidos a uma análise de variância unidirecional (ANOVA). Os resultados das comparações médias dos tratamentos para as características de Thymus kotschyanus L. mostraram que a maior quantidade das características estudadas foi observada no tratamento com SH 30 g/kg. Essas características incluem altura de plantas (19,44 cm), área basal (4,66 cm), cobertura de dossel (99,11%), número de ramos secundários (9,44) e profundidade de enraizamento (16,49 cm), volume de partes aéreas (26,77 cm3), volume de raiz (17,66 cm3), peso fresco de partes aéreas (14,40 g), peso seco de partes aéreas (7,18 g), peso fresco de raiz (3,98 g) e peso seco de raiz (2,07 g). Em geral, o impacto dos tratamentos nas características de crescimento de Thymus foi classificado da seguinte forma: SH 30 g/kg, PSN 1000 mg/L, AM 200 g/kg, SH 10 g/kg, PSN 500 mg/L, AM 100 g/kg, EM 2% e EM 1%. Além disso, as características mais baixas da planta foram encontradas no controle. Em geral, recomenda-se estender o cultivo desta plantamedicinal nativa considerando as condições ecológicas em cada região. Além disso, para promover o estabelecimento e facilitar o crescimento de espécies plantadas, recomenda-se utilizar os facilitadores utilizados no presente trabalho.
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Plantas Medicinales , Thymus (Planta) , Nanoestructuras , Sequías , Hidrogel de Polietilenoglicol-Dimetacrilato , EstiércolRESUMEN
Objective To systematically review the barriers and facilitators affecting the implementation of clinical pathways for the clinical pathways.Methods PubMed, Embase, CNKI, CBM, Wanfang, Cvip databases were searched to collect articles about clinical pathways implementation barriers and facilitators from inception to January 4th, 2019. The tool of confidence in the evidence from reviews of qualitative research ( CERQual) was used to grade the confidence of each study. Results A total of 43 articles from 12 countries were included.There were 8 main categories and 31 subcategories of the barriers about clinical pathways, including content of the clinical pathways, negative outcomes of clinical pathways, physicians knowledge, physicians attitude, resource availability, implementation of activities, patients factors and social factors. The first three barriers of high confidence were lacking of time, capital, equipment, staff and other resources (15 articles, 34.9% ), increasing workload (14 articles, 32.6% ), unrecognizing pathways(12 articles, 27.9% ). There were 6 main categories and 28 subcategories of the facilitators about clinical pathways, including pathways content related, physician related, resource factor and implementation activity. The first three facilitators of high confidence were communication, education and training(25 articles, 58.1% ), supporting from managers and colleagues ( 21 articles, 48.8% ) and establishing a clinical pathway facilitation committee(17 articles, 39.5% ).Conclusions The successful implementation of clinical pathways connects with its development process, aftereffect evaluation and feedback. It will be implemented effectively only by the completely and environmentally acceptable pathways design, adequate resources, effective organizational activities, continuous audit, evaluation and feedback and physicians active cooperation.
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Objective@#To systematically review the barriers and facilitators affecting the implementation of clinical pathways for the clinical pathways.@*Methods@#PubMed, Embase, CNKI, CBM, Wanfang, Cvip databases were searched to collect articles about clinical pathways implementation barriers and facilitators from inception to January 4th, 2019. The tool of confidence in the evidence from reviews of qualitative research(CERQual)was used to grade the confidence of each study.@*Results@#A total of 43 articles from 12 countries were included.There were 8 main categories and 31 subcategories of the barriers about clinical pathways, including content of the clinical pathways, negative outcomes of clinical pathways, physicians knowledge, physicians attitude, resource availability, implementation of activities, patients factors and social factors. The first three barriers of high confidence were lacking of time, capital, equipment, staff and other resources(15 articles, 34.9%), increasing workload(14 articles, 32.6%), unrecognizing pathways(12 articles, 27.9%). There were 6 main categories and 28 subcategories of the facilitators about clinical pathways, including pathways content related, physician related, resource factor and implementation activity. The first three facilitators of high confidence were communication, education and training(25 articles, 58.1%), supporting from managers and colleagues(21 articles, 48.8%)and establishing a clinical pathway facilitation committee(17 articles, 39.5%).@*Conclusions@#The successful implementation of clinical pathways connects with its development process, aftereffect evaluation and feedback. It will be implemented effectively only by the completely and environmentally acceptable pathways design, adequate resources, effective organizational activities, continuous audit, evaluation and feedback and physicians active cooperation.
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Background & objectives: Prediabetes is associated with increased prevalence of cardiovascular disease (CVD). In participants with prediabetes, the effects of exercise and metformin were evaluated on high-sensitivity C-reactive protein (hsCRP) and carotid intima-media thickness (CIMT), surrogate markers of atherosclerosis and CVD compared with standard care. Methods: In a pilot randomized control trial, the participants were randomized in to three arms: standard care (STD), intensive lifestyle modification (ILSM) or ILSM and metformin (ILSM+Met) and followed up for six months. Monitoring of ILSM was done by a trained healthcare facilitator. hsCRP, CIMT and other relevant parameters were measured before and after intervention. Results: A total of 103 participants were randomized into three arms and followed up for six months. At six months, there was a reduction from baseline in weight and fasting blood sugar (FBS) (P <0.01) in all three arms and a reduction in haemoglobin A1c (P =0.03) only in the ILSM+Met arm. The differences in hsCRP over six months within the STD, ILSM and ILSM+Met arms were ?0.12 (95% confidence interval, ?1.81, 2.08), ?0.58 (?2.64, 0.43) and ?0.11 (?1.84, 1.56), respectively. There was no difference in hsCRP, CIMT (right) or CIMT (left) between the three arms at six months. Interpretation & conclusions: There was a reduction in weight and FBS from baseline in all three arms. There was, however, no difference seen in hsCRP and CIMT in the two intervention arms compared to standard care. Larger studies with long-term follow up need to be done to detect differences in risk markers for CVD in prediabetes.
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Gene CaMDR1 is a member of the major facilitator superfamily (MFS),mediating multidrug resistance of Candida albicans,and can confer resistance to benomyl,fluconazole and so forth.In this review,the progress in structure and function of the protein code by gene CaMDR1 and the transcriptional regulation mechanisms of CaMDR1 are summarized.
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Gene CaMDR1 is a member of the major facilitator superfamily (MFS),mediating multidrug resistance of Candida albicans,and can confer resistance to benomyl,fluconazole and so forth.In this review,the progress in structure and function of the protein code by gene CaMDR1 and the transcriptional regulation mechanisms of CaMDR1 are summarized.
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OBJECTIVE: To clone and isolate the major facilitator superfamily(MFS)genes of Polyporus umbellatusand carry out bioinformatic analysis. METHODS: Nine major facilitator superfamily(MFS)genes were cloned fromPolyporus umbellatus sclerotia by RT-PCR and the expression analysis of the nine genes in different parts ofPolyporus umbellatus sclerotia was carried out using quantitative Real-time PCR.RESULTS: The full open reading frame cDNA sequence of these nine genes was between 1 321 and 1 860 bp, the putative encoding proteins were between 441 and 620 amino acids, the molecular weight was between 48.45×103 and 64.79×103 and the theoretical pI was between 6.59 and 9.56. The amino acids of these nine genes possessed 11 to 14 membrane-spanning domains. Phylogenetic tree analysis indicated that Comp34750, Comp34832, Comp29252, Comp42895, Comp32579 and Comp27555 had the highest similarity with MFS general substrate transporter, Comp28872 andComp26306 had the highest similarity with MFS monosaccharide transporter, and Comp33117 had the highest similarity with MFS sugar transporter. Quantitative real-time PCR showed that these nine genes were expressed in both the symbiotic part and non-symbiotic part. Meanwhile, the expressions of seven genes were significantly up-regulated in the symbiotic part except Comp34382 and Comp32579. CONCLUSION: The investigated nine genes might play an important role during the defense response and nutrient absorption of P.umbellatus.
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<p> We report on our experience at the highly interactive special session "General Cardiology Hangout" at the 63rd Annual Scientific Session of the Japanese College of Cardiology, in which the e-portfolio system of Tokyo Medical University and a personal response system (PRS) were used to collect real-time free comments and feedback from the audience.</p><p></p><p> In order to effectively manage an interactive session at an academic meeting by collecting feedback from the audience through a PRS and free comments, it is necessary to train facilitators who have the ability to organically extract and integrate the opinions and feedback from the audience in a relevant matter, and to develop tools that are both more user-friendly and secure.</p>
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Localización. La Región del Bajo Caguán se encuentra localizada en las riberas del río Cagúan, jurisdicción del municipio de Cartagena del Chaira, suroriente del Departamento del Caquetá en la región Amazónica Colombiana. Objetivo. Compartir los resultados metodológicos y de formación logrados mediante las Escuelas de Campo de Agricultores de Theobroma cacao L. desarrollados por la Universidad de la Amazonia en el marco del proyecto: "Desempeño agronómico, evaluación fitosanitaria y caracterización molecular de clones promisorios de Theobroma cacao L. provenientes de materiales vegetales élite presentes en sistemas productivos del bajo Caguán, municipio de Cartagena del Chairá" (ECAs-CAGUAN) que contó con el apoyo de Colciencias, el Comité de Cacaoteros del Bajo Caguán y Suncillas " Chocaguán" y la Parroquia San Isidro Labrador. Metodología. El trabajo se realizó a partir del aprendizaje por descubrimiento, partiendo de los conocimientos y la experiencia previa de los campesinos, la reflexión, la nueva información y la aplicación de la misma. Esta situación implicó la formación a profesionales como facilitadores de ECAs, la definición participativa del currículo, la construcción de protocolos y la aplicación flexible de estos en campo. Resultados. La ECAs - CAGUAN, en su primer ciclo de formación lograron formar a 43 cultivadores y productores de Theobroma cacao L, es decir que el 78% de los que iniciaron el proceso y se logró un Indice de Incremento del Conocimiento (IIC) del 34%. Una de las lecciones aprendidas y quizás la más importante es la necesidad que las ECAs incorporen otros elementos de trabajo que van más allá de lo técnico y está relacionado con estrategias de trabajo social, afectivo y de sensibilidad, esto contribuirá a mejorar los procesos de adopción tecnológica en campo. Conclusiones. El proceso de las ECAs- Caguan, permitió a los agricultores entre otras cosas entender que el hallazgo de los élites y/o el mejoramiento genético es solo un factor que ayudará a que su producto mejore, pero la mayor responsabilidad está precisamente en ellos mismos, en la realización de las prácticas culturales y de manejo de sus cultivos.
Location. The Bajo Caguan region is located on the banks of the Cagúan River, municipality of Cartagena del Chaira, southeast of the Department of Caquetá in the Colombian Amazon region. Objective. To share methodological and training results achieved through Theobroma cacao L. Farmer Field Schools developed by the University of the Amazon under the project: "Agronomic performance, phytosanitary evaluation and molecular characterization of promising Theobroma cacao L. clones from elite plant material present in productive systems in the Bajo Caguan municipality of Cartagena del Chairá" (RCT-Cagúan) that was supported by Colciencias, the Cocoa Committee of Bajo Caguan and Suncillas, "Chocaguán",and the San Isidro Labrador Parish. Methodology. The work was conducted from discovery learning, based on the farmers previous knowledge and experience, reflection, new information and its application. This involved training professionals as FFS facilitators, the participatory definition of curriculum, building of protocols and flexible application of these in the field. Results. The FFS - Cagúan, in its first training cycle managed to train 43 farmers and producers of Theobroma cacao L, which means that 78% of those who started the process achieved an increase of Knowledge Index (IIC) of 34%. One of the lessons learned and perhaps the most important one, is the need to incorporate to the FFS other work items that go beyond the technical and that are related to social work, affective and sensitivity strategies, which will help improve technological adoption processes in the field. Conclusions. The FFS-Caguan process, allowed farmers, among other things, to understand that finding the elites and/or genetic improvement is only one factor that will help improve their product, but the main responsibility lies precisely in themselves, in conducting cultural practices and crop management.
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Humanos , Agricultores , Universidades , Cacao , Ecosistema AmazónicoRESUMEN
Background: Problem based learning (PBL) is a student - centered curriculum delivery tool believed to promote active student participation. Though the PBL is student - centered, the facilitator plays an important role in maintaining the integrity of this system by providing balance in group interaction and discussion of learning issues. In International Medical University (IMU) one of the strategies to ensure the quality of the facilitators was the pre and post PBL meetings. This study aimed to gauge its usefulness in ensuring the quality of PBL facilitation. Method: The questionnaire to study the perceptions of PBL facilitators on the pre and post PBL meetings included close ended questions on pre and post PBL meeting’s attendance and their scored opinion in improving PBL facilitation skills, open ended questions inviting suggestions to improve these meetings and PBL facilitation in IMU as a whole and self-evaluation as an effective PBL facilitator using a six point Likert scale to a list of statements. Results: 84.2% of facilitators agreed the meetings were beneficial. Self-evaluation of their facilitator effectiveness showed on average ratings of seven out of ten indicating strong confidence in facilitating skills. Suggestions ensuring facilitator quality included content expert briefing in pre PBL meetings and student appraisals of facilitators given weightage in staff appraisal. Conclusion: Pre and post PBL meetings enhanced facilitator comfort with the triggers, adding to their confidence and provided a venue to obtain feedback on the triggers.
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PURPOSE: The purpose of this study was to identify knowledge, facilitators, and barriers of breast self -examination(BSE) in Korean couples for developing a continuous regular BSE promotion program. METHOD: This descriptive study was undertaken with a focus group methodology including 27 couples of husbands and wives recruited by convenience-sampling. Data transcribed from audiotapes was analyzed to identify common themes. RESULTS: Knowledge of breast cancer and BSE included 'the risk factors of breast cancer', 'prevention of breast cancer', and 'how to do BSE'. Facilitators to BSE included 'self, health professional, and spouse-facilitating factors'. Barriers to BSE included 'cognitive, psychological, informational, and physical barriers'. CONCLUSION: To promote compliance with BSE among women, tailored programs according to the stage of change of BSE adoption are crucial, not only reflecting the specific needs of the individual by the stage of change, but also utilizing husbands as facilitators.
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Femenino , Humanos , Neoplasias de la Mama , Autoexamen de Mamas , Mama , Adaptabilidad , Composición Familiar , Grupos Focales , Empleos en Salud , Factores de Riesgo , Esposos , Grabación en CintaRESUMEN
<b>Purpose</b>: The purpose of this study was to develop and evaluate a training program for facilitators operating a support group (SG) for cancer patients. <b>Methods</b>: The training program was structured and implemented as a two-day program for members of the nursing profession with experience in providing care for cancer patients. An original questionnaire, developed to ascertain knowledge regarding SG operation, and for evaluating anxiety and self-efficacy was designed for use before and after going through the program to allow for comparative evaluation. The subjects of this analysis were 58 nurses taking part in the program. <b>Results</b>: As a result, the knowledge of how to operate SG increased significantly (p<0.05) following participation. Of the 12 items addressing anxiety and self-efficacy regarding SG operation, lessening of anxiety was noted in 3 items, and self-efficacy was seen to improve significantly in 7 items. Motivation and resolve concerning SG operation following participation in the program also increased significantly. <b>Conclusion</b>: This was a useful training program for facilitators operating support groups for beginners.
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In the struggle for life, the capacity of microorganisms to synthesize and secrete toxic compounds (inhibiting competitors) plays an important role in successful survival of these species. This ability must come together with the capability of being unaffected by these same compounds. Several mechanisms are thought to avoid the toxic effects. One of them is toxin extrusion from the intracellular environment to the outside vicinity, using special transmembrane proteins, referred to as transporters. These proteins are also important for other reasons, since most of them are involved in nutrient uptake and cellular excretion. In cancer cells and in pathogens, and particularly in fungi, some of these proteins have been pointed out as responsible for an important phenotype known as multidrug resistance (MDR). In the present study, we tried to identify in the Paracoccidioides brasiliensis transcriptome, transporter-ortholog genes from the two major classes: ATP binding cassette and major facilitator superfamily transporter. We found 22 groups with good similarity with other fungal ATP binding cassette transporters, and four Paracoccidioides brasilienses assembled expressed sequence tags that probably code for major facilitator superfamily proteins. We also focused on fungicide resistance orthologs already characterized in other pathogenic fungi. We were able to find homologs to C. albicans CDR1, CDR2, and MDR1, Saccharomyces cerevisiae PDR5 and Aspergillus AtrF genes, all of them related to azole resistance. As current treatment for paracoccidioidomycosis mainly uses azole derivatives, the presence of these genes can be postulated to play a similar role in P. brasiliensis, warning us for the possibility of resistant isolate emergence.