Effects of chromium picolinate supplementation in type 2 diabetic patients / Efeitos da suplementação com picolinato de cromo em pacientes portadores de Diabetes mellitus tipo 2

The effects of chromium picolinate in Type 2 diabetic patients are investigated. Seventeen Type 2 diabetic patients were randomly divided into two groups. The experimental group received fiber-rich hypocaloric diet and chromium picolinate whereas the control group received fiber-rich hypocaloric diet and placebo. The chromium picolinate was offered twice a day at the dose of 100 µg. Anthropometric data such as blood pressure, fasting glycemia and glycated hemoglobin (HbA1c) were measured and these parameters were evaluated again after 90 days. No difference was reported in rates of body weight, waist, hip, body mass index, blood pressure and fasting glycemia (Control vs. Experimental groups) after treatment. However, a decrease (p = 0.0405) of HbA1c occurred in the experimental group when the pre-and post-treatment rates were compared. HbA1c data showed that chromium picolinate improved the glycemic control in Type 2 diabetes.

Neste estudo investigamos os efeitos do picolinato de cromo em pacientes portadores de Diabetes mellitus tipo 2. Para alcançar este objetivo 17 pacientes foram aleatoriamente divididos em 2 grupos. O grupo Experimental recebeu dieta hipocalórica rica em fibras e picolinato de cromo enquanto o grupo Controle recebeu dieta hipocalórica rica em fibras e placebo. Picolinato de cromo foi oferecido na dose de 100 µg, 2 vezes ao dia. Avaliamos os dados antropométricos, pressão arterial, glicemia de jejum e hemoglobina glicada A1c (HbA1c), sendo estes parâmetros reavaliados após 90 dias. Os resultados de peso, cintura, quadril, índice de massa corpórea, pressão arterial e glicemia de jejum, antes e após o tratamento não foram diferentes (Controle vs. Experimental). Contudo, houve redução (p = 0,0405) da HbA1c no grupo Experimental, ao compararmos os valores antes e após o tratamento. Portanto, a partir dos dados de HbA1c foi possível evidenciar que o picolinato de cromo melhora o controle glicêmico no Diabetes mellitus tipo 2.

Valor pronóstico de la primera glucemia en ayunas al ingreso hospitalario en personas con infarto agudo del miocardio / Prognostic value of the first fasting glycemia on hospital admission in people with acute myocardial infarction

Antecedente: se describe que la primera glucemia en ayunas en hospitalizados por infarto agudo del miocardio se asocia a un mal pronóstico. Objetivo: determinar la posible influencia de la hiperglucemia, en particular la primera glucemia en ayunas, en el pronóstico del infarto agudo del miocardio. Métodos: se realizó un estudio transversal y descriptivo donde se revisaron 157 historias clínicas de ingresados en la Unidad de Cuidados Coronarios del Instituto de Cardiología y Cirugía Cardiovascular, en la provincia de La Habana, con el diagnóstico de infarto agudo del miocardio (enero del año 2006 a diciembre del año 2007). Se dividieron en tres grupos: I) Sin antecedentes de diabetes mellitus con hiperglucemia al ingreso, II) con diagnóstico previo de diabetes mellitus al ingreso; y III) no diabéticos, sin hiperglucemia al ingreso. Variables estudiadas: edad, sexo, hábito de fumar, consumo de alcohol, cifras de la primera glucemia en ayunas, promedio de los valores de glucemia durante su estadía hospitalaria, tratamiento insulínico (convencional o intensivo), complicaciones del infarto agudo del miocardio, su evolución (mortal o no mortal) y estadía hospitalaria. Se correlacionaron los valores de glucemia y su tratamiento con las complicaciones cardiovasculares, la mortalidad y la estadía hospitalaria. Resultados: los grupos I y II presentaron mayores porcentajes de complicaciones dependientes del infarto agudo del miocardio, y mayor mortalidad a mayores cifras de la glucemia intrahospitalaria. Hubo una tendencia no significativa del pronóstico de la primera glucemia en ayunas. Conclusiones: el control metabólico malo o regular (intrahospitalario) se asocia a un mal pronóstico y a una mayor estadía hospitalaria. No hubo relación significativa de la primera glucemia en ayunas con la mortalidad en el infarto agudo del miocardio.

Background: it is described that the first fasting glycemia in people hospitalized with acute myocardial infarction is associated to a bad prognosis. Objective: to determine the possible influence of hyperglycemia, particularly in the first fasting glycemia, for the prognosis of acute myocardial infarction. Methods: a transversal and descriptive study was conducted in which 157 clinical histories of patients admitted to the Coronary Care unit of the Institute of Cardiology and Cardiovascular Service in Havana Province, who were diagnosed with acute myocardial infarction, were reviewed (January 2006-December 2007). They were divided into three groups: 1) without antecedents of diabetes mellitus, with hyperglycemia on admission; 2) with previous diagnosis of diabetes mellitus on admission; 3) non-diabetics, without hyperglycemia on admission. The variables studied were: age, sex, smoking habit, alcohol intake, levels of first fasting glycemia, average values of blood glucose during hospitalization, insulin treatment (conventional or intensive), complications of acute myocardial infarction, evolution (mortal or non-mortal) and hospital stay. The values of glycemia and its treatment were correlated with cardiovascular complications, mortality and hospital stay. Results: groups 1 and 2 presented higher percentages of complications of acute myocardial infarction as well as a greater mortality in higher numbers of intra-hospital blood glucose. There was a non significant tendency of first fasting glycemia with this prognosis. Conclusions: the bad or regular intra-hospital metabolic control is associated to a bad prognosis and a greater hospital stay. There was no significant relation between first fasting glycemia and mortality after acute myocardial infarction.

Serum C-reactive protein levels in subjects with impaired fasting glycemia and its clinical significance / 中国实用内科杂志

Objective To investigate the levels of serum C-reactive protein in subjects with impaired fasting glycemia and its significance.Methods From Mar.to Sep.2005,according to oral 75 g glucose tolerance test(OGTT)in the patients in the First Hospital Affiliated to China Medical University,there are 30 subjects with normal glucose tolerance(NGT),28 cases with impaired fasting glycemia(IFG).CRP was detected with ELISA.Results (1)Serum CRP in the subjects with impaired fasting glycemia was significantly higher than those in normal subjects( P