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Background: Helicobacter pylori (H. pylori) is a gram-negative, spiral shaped pathogenic bacterium that specifically colonizes the gastric epithelium causing chronic gastritis, peptic ulcer disease, and/or gastric malignancy.Aim: To assess the effect of H. pylorion fibrinogen level of Sudanese patients with diabetes millets (D.M) living in Khartoum state.Subjects and Methods: This was case control study conducted among Sudanese diabetic patients during the period from May 2018 to July 2021. A total of 181 diabetics patients are involved in this study. Citrated blood and stool samples were collected from each participant. All stool samples were tested for the presence of H. pylori antigen by using commercially available H. pylori antigen detection card. Based on the result examination for H. pylorithe study population are sub grouped in two groups one group 124 of cases with Positive H. pylori antigen and another group 57 of controls with negativeH. pylori infection. Both groups were assessed for the fibrinogen level. Data was gathered and analyzed by using SPSS version 20.Results: Our results revealed that cases have slightly higher values of fibrinogen levels 326.29± 89.99 mg/dl compared to 309.47± 90.82 mg/dl for control group. However, the statistical analysis indicate that the difference was remain insignificant with P-value of 0.246. Among cases group gender concerned the fibrinogen concentration mean in the plasma of male 336.2±98.5 mg/dl was higher than female 311.1±73.4 mg/dl.Conclusion:they were insignificant association between fibrinogen level and presence of H. pyloriinfection among Sudanese diabetic patients. gender concerned the fibrinogen concentration in the plasma in H. pylori among males showed higher levels than females.
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Background: Stroke is a disease of paramount public health significance. The role of plasma fibrinogen in determining incidence and severity of stroke has been postulated time and again. Present study was undertaken to determine the correlation between mean plasma fibrinogen level and infarct volume on CT scan in patients with acute stroke.Methods: Present prospective observational study of two years duration at our tertiary care government centre entailed enrollment and radiological assessment (CT scan/MRI) of 50 consecutive patients with first-ever stroke admitted within 24 h after stroke onset along with measurement of their plasma fibrinogen levels at admission.Results: Thirty (60%) cases reported ischemic stroke while haemorrhagic stroke was observed in 20 (40%) cases. The mean fibrinogen levels in ischemic (584±62mg/dl) and haemorrhagic stroke (52±28mg/dl) were found to be significantly higher (p<0.05) than normal range of (200-400mg/dl). The mean infarct volume in patients with ischemic stroke was 62.79±9.51cm3 while mean plasma fibrinogen level was 584±62mg/dl. There was significant correlation between infarct volume and fibrinogen levels (r coefficient =0.61; p<0.05). The fibrinogen levels in patients who died was insignificantly higher as compared to patients who survived.Conclusions: We report significantly higher than normal mean fibrinogen levels in ischemic and haemorrhagic stroke with the correlation between infarct volume and fibrinogen levels being significant in ischemic stroke. Limited mortality numbers probably didn’t allow the present study to reach the level of significance. Similar studies with larger sample size are recommended.