RESUMEN
Objective To study the initial etiology of Kashin-Beck Disease (KBD). Methods Three past etiological hypotheses, biology-earth-chemistry hypothesis (selenium deficient hypothesis), water organic compound poisoning hypothesis and food fungi toxin poisoning hypothesis were studied, together with the virus hypothesis we have developed synchronously to explore the initial etiology of KBD. Results Biology-earth-chemistry hypothesis (selenium absent hypothesis), water organic compound poisoning hypothesis and food fungi toxin poisoning hypothesis were not to be found the initial etiology of KBD. The etiology mode of KBD should be the biologic toxin poisoning under certain environmental condition. The human parvovirus B 19 infection under selenium deficient condition is significantly correlated with KBD. Conclusion The initial etiology of KBD may be the human Parvovirus B 19 infection under selenium absent condition.