RESUMEN
Gelatinous transformation of bone marrow is characterized by hypoplasia of fat cells with focal loss of hematopoietic cells and deposition of extracellular gelatinous substances. It is known to be associated with devastating underlying diseases that starve bone marrow. Here, we present a case of a patient whose magnetic resonance (MR) imaging findings of vertebral column were interpreted as metastasis or hematologic malignancy, however, the final diagnosis revealed a gelatinous transformation of bone marrow. This is the first report of gelatinous transformation of bone marrow without evidence of underlying devastating disease.
Asunto(s)
Humanos , Adipocitos , Médula Ósea , Diagnóstico , Gelatina , Neoplasias Hematológicas , Imagen por Resonancia Magnética , Metástasis de la Neoplasia , Tomografía de Emisión de Positrones , Columna VertebralRESUMEN
We experienced a case of gelatinous transformation of bone marrow in a patient with congestive heart failure in malnutrition. The biopsy findings of bone marrow were gelatinous transformation, a condition characterized by disruption of marrow architecture, fat atrophy, and deposition of hyaluronic acid. Gelatinous transformation is often mistaken as representing edema, necrosis, or amyloidosis.
Asunto(s)
Humanos , Amiloidosis , Atrofia , Biopsia , Médula Ósea , Edema , Estrógenos Conjugados (USP) , Gelatina , Insuficiencia Cardíaca , Ácido Hialurónico , Desnutrición , NecrosisRESUMEN
Gelatinous bone marrow transformation (GMT) is rare. It has been found to be associated with severe illnesses and malnutrition (rarely). A case report highlighting GMT as " starvation marrow" along with review of literature is being presented.
Asunto(s)
Médula Ósea , Desnutrición , InaniciónRESUMEN
Gelatinous transformation of the bone marrow is rarely found and characterized by accumulation of hyaluronic acid, fat atrophy and associated with bone marrow hypoplasia. This process has been reported to occur in severely malnourished patients. We report an anorexia nervosa patient showing pancytopenia and hypoplastic bone marrow associated with gelatinous transformation. Pathogenesis of this lesion remains unclear.