RESUMEN
RESUMO Um caso interessante da aplicação dos polímeros condutores funcionalizados na análise do fármaco hidroxizina em soluções ácidas vem sendo descrito do ponto de vista teórico. Um modelo matemático, correspondente ao caso, é desenvolvido e analisado mediante a teoria de estabilidade linear e da análise de bifurcações. Foi detectado que o uso de um polímero condutor de natureza ácida no processo pode deixar o uso das soluções menos ácidas do fármaco sem prejuízo para a eficiência eletroanalítica. Outrossim, foi avaliada a influência para o processo do comportamento dos grupos amina. A possibilidade das instabilidades oscilatória e monotônica também foi verificada.
SUMMARY An interesting case of the application of the functionalized conducting polymer in the analysis of hydroxyzine drug in acid solutions is described from the theoretical point of view. A mathematical model, correspondent to the case, is developed and analyzed by means of linear stability theory and bifurcation analysis. It was detected that the use of an acid conducting polymer may permit the use of less acid solution without mischief of the electroanalytical efficiency. Moreover, the influence of the aminogroups' behavior to the process was also evaluated. The possibility of the oscillatory and monotonic instabilities has also been verified.
RESUMEN
A retrospective case study was performed using the clinical charts of patients diagnosed with atopic dermatitis, dermatitis, urticaria, and other allergic conditions, treated with hydroxyzine hydrochloride from the period of 2001 to 2003. Patients of both sexes were identified by the diagnosis and treatment prescribed, and having returned for at least one post-treatment visit. A total of 41 patients were identified who fulfilled the criteria for this safety and efficacy analysis of hydroxyzine hydrochloride. The results suggest that hydroxyzine is an effective antihistaminic agent in the treatment of numerous allergic and inflammatory conditions.