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@#This paper summarized the clinical experience of AI Rudi in the treatment facial hormone-dependent dermatitis with the method of clearing heat and protecting yin. It is believed that the key pathogenesis is the heat toxin accumulation， yin depletion and collaterals obstruction. The clinical treatment should focus on “heat exuberance” and “yin depletion”. It is advocated that “half treatment is from heat and half from yin” is the general principle， and the treatment is staged. In the acute phase， the treatment is half from cooling blood and dispersing wind to dispel heat pathogen， and half from protecting fluid and moisturizing skin to strengthen yin； and the modified Liangxue Xiaofeng Powder （凉血消风散） could be used. In the chronic phase， half treatment is from clearing residual toxin to eliminate heat pathogen， and half from nourishing yin and unblocking collaterals to strengthen yin， for which Xuanmai Ganju Decoction and Erzhi Pills （玄麦甘桔汤合二至丸） can be used and modified according to the symptoms. At the same time， we should pay attention to the simultaneous internal and external treatment， and emphasize the importance of daily protection in the treatment of the disease.
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This paper summarized the clinical experience of AI Rudi in the treatment facial hormone-dependent dermatitis with the method of clearing heat and protecting yin. It is believed that the key pathogenesis is the heat toxin accumulation， yin depletion and collaterals obstruction. The clinical treatment should focus on “heat exuberance” and “yin depletion”. It is advocated that “half treatment is from heat and half from yin” is the general principle， and the treatment is staged. In the acute phase， the treatment is half from cooling blood and dispersing wind to dispel heat pathogen， and half from protecting fluid and moisturizing skin to strengthen yin； and the modified Liangxue Xiaofeng Powder （凉血消风散） could be used. In the chronic phase， half treatment is from clearing residual toxin to eliminate heat pathogen， and half from nourishing yin and unblocking collaterals to strengthen yin， for which Xuanmai Ganju Decoction and Erzhi Pills （玄麦甘桔汤合二至丸） can be used and modified according to the symptoms. At the same time， we should pay attention to the simultaneous internal and external treatment， and emphasize the importance of daily protection in the treatment of the disease.
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Objective:To observe the changes of skin lesion, anxiety and depression in patients with facial hormone-dependent dermatitis before and after treatment.Methods:Ninty-two cases of hormone-dependent dermatitis were collected from October 2014 to December 2020 in the Department of Dermatology, the First People＇s Hospital of Changshu, Jiangsu province, including 24 males and 68 females, aged 18 to 52 (31±10) years. The skin lesions and subjective symptoms changes were compared 2 weeks and 4 weeks after treatment. Depression and anxiety changes were compared before and after treatment with Hamilton depression scale and Hamilton anxiety scale. Telephone follow-up was conducted 4 weeks and 8 weeks after treatment.Results:The skin lesions and subjective symptoms of the 92 cases were improved in different degrees after 2 weeks and 4 weeks treatment, and the effective rates were 52.17% (48 cases) and 88.04% (81 cases) respectively, and the difference was statistically significant ( Z=-9.24, P<0.01). The depression scores (16.89±4.53) before treatment were significantly higher than those after treatment (4.38±2.10), and the difference was statistically significant ( t=35.79, P<0.01). 28 cases (30.43%) had clinically significant depression symptoms before treatment, and none after treatment. The difference was statistically significant ( Z=-5.39, P<0.01). The scores of anxiety (14.39±3.97) before treatment were significantly higher than those after treatment (4.46±1.67). and the difference was statistically significant ( t= 28.87, P<0.01). 50 cases (54.35%) had clinically significant anxiety symptoms before treatment, and none after treatment. The difference was statistically significant ( Z=-7.07, P=<0.01). The total scores of Hamilton depression scale were positively correlated with course of disease before and after treatment ( r=0.27, P<0.05; r=0.22, P<0.05). The total scores of Hamilton anxiety scale were positively correlated with course of disease before and after treatment ( r=0.29, P<0.01; r=0.35, P<0.01). They were followed up by telephone 4 weeks and 8 weeks after the end of treatment, and there was no relapse. Conclusions:Facial hormone-dependent dermatitis can affect appearance, leading to depression and anxiety, and early and full treatment can achieve satisfactory results.
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Aggressive angiomyxoma (AA) is an extremely rare locally invasive mesenchymal tumor with a high risk of recurrence. Till date, only about 350 cases reported worldwide. Because of the rarity it should be considered as differential diagnosis whenever patient present with vulvovaginal growth. The diagnosis is clinched on histopathology. These are hormone-dependent and have estrogen and progesterone receptors. Hence sometimes GnRH agonists are used for ovarian estrogen secretion suppression but long-term use is not advocated due to side effects. A 45-year-old P4 L4 perimenopausal female presented to the GOPD with a 4×4×3 cms pedunculated painless globular mass on right labia majora. On palpation, the globular mass was firm, non-tender and with a smooth surface. Mass was excised and on gross histopathology, cut sections showed white myxoid areas. On microscopy epidermal lined tissue with stellate and spindle-shaped mesenchymal cells was found, embedded in a loose myxoid stroma with few collagen fibers. The cells were small and bland and lacked nuclear atypia. Small to medium-sized blood vessels were present with the thickened wall. Entrapped nerves and adipocytes were also present. No necrosis or mitosis was identified. All these features were suggestive of an aggressive angiomyxoma. Immunohistochemistry markers ER, PR, CD34, desmin, SMA were all positive. Imaging was done to rule out metastatic lesions and wide local excision was done around the stump with laparoscopic bilateral oophorectomy. Aggressive angiomyxoma is a rare disease. In women with asymptomatic growth in the vulvovaginal region, perineum or pelvis, aggressive angiomyxoma should be considered as a differential diagnosis. Ideal treatment is a wide local excision to prevent local recurrences, which are common and a hypoestrogenic milieu is created by either GnRH Agonists or by bilateral oophorectomy due to their hormone-sensitive nature.
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Objective: To investigate the in vitro antiproliferative action of essential oil from Salvia officinalis L. (S. officinalis) grown in Sicily (Italy), and its main components on hormone-dependent cancer cell lines. Methods: S. officinalis essential oil was prepared by hydrodistillation. The actions of the S. officinalis essential oil and its three principal components ( -thujone, 1,8-cineole and camphor) were evaluated in LNCaP cells (prostate carcinoma), MCF7 cells (breast carcinoma) and HeLa cells (cervical carcinoma) at various dosages and diverse time points. Cell viability and proliferation were estimated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Results: S. officinalis essential oil at doses of 100 μg/mL and 200 μg/mL induced a significant reduction of cell viability in MCF7, LNCaP and HeLa cell lines after a 48-hour incubation. The same cell lines also showed decreased cell viability when they were treated with a mixture of three major components of the essential oil, at doses of 100 μg/mL and 200 μg/mL, after a 48-hour incubation. Conclusions: These preliminary results could shed light on the formulation of new therapeutic agents with antiproliferative activity. Thus supplementary investigations are fundamental to examine the molecular mechanisms of the anticancer effects of this species of Salvia in cancer cells and to achieve confirmation of its in vivo anticancer activity.
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Objective To investigate and explore expression status of microRNA-218,and their correlation in serum and tissue samples of prostate cancer patients.Methods The serum and tissue samples of 72 patients in first diagnosised prostate cancer (PCa) and 80 benign prostate hyperplasia (BPH) patients were collected.Serum samples of 162 patients,including 86 patients with androgen-dependent prostate cancer (ADPC) and 76 patients with hormone-refractory prostate cancer (HRPC) were collected.The expression level of microRNA-218 in the tissue and serum samples were detected by specific SYBR Green quantitative real-time polymerase chain reaction (PCR).The correlation between the serum microRNAs and tissue microRNAs expressions tatus were analyzed,and their relationship with clinical characterization were also analyzed.Results The expression level of microRNA-218 in tissues and serum of patients with BPH was higher than that of patients with PCa (P ≤0.001).MicroRNA-218 level in PCa and BPH tissue were both correlated with that in the serum of PCa and BPH (rBPH =0.815,rPCa =0.423).The expression level of microRNAs in tissue and serum samples from PCa were negatively correlated to total prostate specific antigen (tPSA),clinical stages and pathological grade (P ≤0.05).Serum microRNA-218 expression was not significantly different between hormone-dependent PCa patients and newly diagnosed PCa patients,but was significantly lower than that of HRPC patients (P ≤ 0.05),and was positively correlated with tPSA (P ≤0.05).Conclusions The changes of microRNA-218 expression in serum of patients with BPH and prostate cancer can reflect the changes of microRNA-218 expression in tissues.Serum microRNA-218 is expected to be a potential biomarker for early diagnosis and progression of prostate cancer.
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Objective:To explore the clinical effect of compound glycyrrhizin tablets combined with recombinant bovine basic fibroblast growth factor gel in the treatment of facial hormone-dependent dermatitis. Methods:Totally 108 patients with facial hormone-dependent dermatitis were selected randomly and divided into the control group(n = 54) and the treatment group(n =54). The control group was treated with desloratadine and 0.1% tacrolimus ointment;and the treatment group was treated with compound glycyrrhizin tablets combined with recombinant bovine basic fibroblast growth factor gel additionally on the basis of control group. The clinical efficacy of the two groups was evaluated,and the improvement of symptoms and objective signs before and after the treatment was compared. The adverse reactions were recorded as well. Results:The total effective rate of the treatment group after one-month and two-month treatment was 75.93% and 90.74%, respectively, which were both higher than those of the control group(P < 0.05). The scores of symptoms and objective signs and the total scores of disease of the treatment group after one-month and two-month treatment and two-month follow-up were all lower than those of the control group, and the differences were statistically significant(P <0.05). The disappearance time of objective signs and the incidence of facial adverse reactions were both lower than those of the control group,and the differences were statistically significant(P < 0.05),however, the incidence of dry mouth in the treatment group was higher than that in the control group(P < 0.05). Conclusion:Compound glycyrrhizin tablets combined with recombinant bovine basic fibroblast growth factor gel has better clinical effect for the therapy of facial hormone-dependent dermatitis,which can improve the symptoms significantly with high application security.
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[Objective]To observe the clinical effect of the treatment of hormone dependent asthma by Bushen Yiqi Decoction. [Methods]84 cases of hormone dependent asthma in the Affiliated Hospital of Nanjing University of Chinese Medicine from December 2011 to December 2015 were selected. According to the random number table, 84 cases were randomly divided into two groups:control group and observation group, 42 cases in each group. Control group was in accordance with the GINA guidelines recommended fourth level of treatment. Observation group, on the basis of the control group, treated hormone dependent asthma by western medicine in combination with Bushen Yiqi Decoction. [Results] The total effective rate of observation group was 88.1%, and the total effective rate of control group was 71.43%. Two groups of comparison, the difference was statistically significant( P<0.05); IL-5, IL-4, EOS levels were decreased after treatment in the two groups(P<0.05), but the observation group decreased more significantly, compared with the control group, the difference was statistically significant(P<0.05);During treatment and after treatment, reduction rate of using hormone and antiasthmatics in control group and observation group was respectively(85.7%VS64.3%) and(78.6%VS61.9), two groups of comparison, the difference was statistically significant( P<0.05). [Conclusion]Compared with the pure oral hormone plus inhalation in the treatment of hormone dependent asthma, application of Bushen Yiqi Decoction has obvious curative effect and can reduce the dosage of hormone and side effects. It is worthy of clinical promotion.
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Objective To evaluate the efficacy and safety of near-infrared light combined with tacrolimus 0.1％ ointment in the treatment of facial glucocorticoid-dependent dermatitis.Methods A total of 68 patients with facial glucocorticoid-dependent dermatitis were enrolled from Department of Dermatology of Yantai Yuhuangding Hospital between December 2014 and December 2015,and randomly and equally divided into treatment group and combination group by a random number table.The treatment group was treated topically with tacrolimus ointment twice a day for 4 weeks.Besides the treatment with tacrolimus ointment,the combination group was irradiated with near-infrared light once a week for 4 sessions.After 4-week treatment,improvement in clinical manifestations such as itching and burning sensation was evaluated,so was the therapeutic effect.Results The combination group showed significantly higher response rate (85.3％ [29/34]) compared with the treatment group (61.8％ [21/34],x2 =4.84,P ＜ 0.05).Additionally,response rates for itching and burning sensation,erythema,scales and papules were all significantly higher in the combination group than in the treatment group (x2 =4.84,6.35,8.42 and 5.52,respectively,all P ＜ 0.05).Conclusion Near-infrared light combined with tacrolimus ointment is effective and safe for the treatment of facial glucocorticoid-dependent dermatitis.
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Objective To study the clinical effects of recombinant human epidermal growth factor (rhEGF) gel combined with tacrolimus treatment on facial hormone-dependent dermatitis, and to investigate its influence in skin function and recurrence of dermatitis. Methods Forty-eight outpatients with facial hormone-dependent dermatitis were randomly divided into treatment group (n=24, treatment with tacrolimus combined rhEGF gel) and control group (n=24, treatment with tacrolimus). The moisture of skin, sebum content and transepidermal water loss (TEWL) were examined before treatment and 4 weeks after treatment in two groups. Eczema area and severity index (EASI) were calculated at 1 week, 2 weeks and 4 weeks after treatment. The adverse reactions and recurrence of dermatitis were observed during the treatment as well. Results Compared with pre-treatment, the moisture of skin and sebum content were increased (P0.05), but it is much higher in treatment group after two-week treatment (79.2%vs. 50.0%, P<0.05) and after four-week treatment (91.2% vs. 62.5%, P<0.05). Furthermore, there was no adverse reaction in the treatment group, and the recurrence rate was much lower in treatment group (12.5%) than that of the control group (37.5%,χ2=4.03,P<0.05). Conclusion Recombinant human epidermal growth factor gel has an auxiliary curative effect on facial hormone-dependent dermatitis and can significantly improve skin function, and the recurrence rate of dermatitis is low.
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Objective To study the distribution characteristics of TCM constitutions of hormone-dependent breast cancer patients; To provide references for TCM diagnosis and treatment.Methods TCM constitution differentiation in the 210 patients with hormone-dependent breast cancer were investigated by a questionnaire survey, which is made according to the Classification and Determination of TCM Constitutions invented by professor Wang Qi and four methods of diagnosis of TCM, with a purpose to investigate the correlation of TCM constitutions and TCM syndrome differentiation typing.Results There was statistical significance among TCM constitutions of the 210 patients with hormone-dependent breast cancer (P<0.001), with yin deficiency 43.8% (92 cases), qi stagnation 15.2% (32 cases), qi deficiency 11.4% (24 cases), blood stasis 7.6% (16 cases), and yang deficiency 6.7% (14 cases). There was statistical significance among TCM syndromes (P<0.001), with dysfunction of Chong and Ren channels 63.8% (134 cases), stagnation of liver qi syndrome 16.2% (34 cases), weakness of the spleen and stomach syndrome 11.4% (24 cases). There was statistical significance between dysfunction of Chong and Ren channels and correlation of TCM constitutions (P<0.001).Conclusion Most hormone-dependent breast cancer patients are accompanied with yin deficiency pattern and the syndrome differentiation typing of dysfunction of Chong and Ren channels. There is correlation between dysfunction of Chong and Ren channels and TCM constitutions.
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Objective To investigate clinical effect of collagen dressing in treatment of facial hormone dependent dermatitis.Methods 107 patients were divided randomly into treatment group and control group.53 cases of control group were given citrate desloratadine,ompound glycyrrhizin tablets, 0.3% tacrolimus ointment, cod liver oil ointment for 4 weeks.54 cases of treatment group were given collagen dressing 25 minutesper night, based on control group.After 4 weeks of drug treatment,treatment group continued to be given collagen dressing once every other night, control group were given cod liver oil ointment twice a day, morning and night.Both groups continued to observe for 12 weeks, at the same time, 0.3% tacrolimus ointment was given once every other day.Compared effect of two groups in the short-term and long-term.Results There were no significant differences in symptom scores between the two groups pre-treatment; compared with pre-treatment,the symptom scores were decreased(P<0.05).Compared with control group, the symptoms of treatment group were lower than that of treatment group(P<0.05).Compared with control group, the clinical total effective rate was higher than treatment group ( P<0.05 ) .Conclusion The collagen dressing can improve the facial treatment of hormone-dependent dermatitis.
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This study was aimed to observe the mechanism of Jia-Jian Xiao-Yao (JJXY) Powder improving facial skin barrier function of the hormone-dependent dermatitis patients. A total of 100 patients were randomly divided into two groups. In the treatment group, 50 cases were orally administered with JJXY Powder. In the control group, loratadine and vitamin EC particles were orally administered to the 50 cases. Thirty days is one treatment course. Changes of transepidermal water loss (TEWL), skin erythema amount and IL-4 were detected in patients of both groups before and after the treatment. The results showed that the clinical efficiency of treatment group and control group was 82.0% and 58.0%, respectively. In the treatment group, the TEWL and skin erythema amount were obviously decreased after the treatment (P < 0.05). In the treatment group, the decreasing range of serum IL-4 was significant compared to control group (P < 0.05). It was concluded that JJXY Powder is one of the effective methods for the treatment of facial hormone-dependent dermatitis. It is able to repair facial hormone-dependent dermatitis in patients with impaired skin barrier function and reduce the amount of skin erythema. The therapeutic mechanism may be related to the regulation of serum IL-4.
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ObjectiveTo investigate theeffect of combining traditionalChineseandWestern medicine therepy for patients with hormone-dependent dermatitis.Methods The relative literature conceming the clinical trials in treating patients with hormone-dependent dermatitis with therapy of combining traditional Chinese and Western medicine between 2005 and 2011 were retrieved,and Meta-analysis was made on the qualified literature by means of Review Manager 5.0 software.Results 15 randomized trials with 1749 patients met inclusion criteria.Compared with western medicine treatment group,the test results of the effective rate on the patients with hormone-dependent dermatitiswiththerapyof combining traditionalChineseandWestem medicinewasZ =12,P＜0.00001,OR =4.2 ( 95％ CI,3.32 t0 5.31).ConclusionPatients with hormone-dependent dermatitis with therapy of combining traditional Chinese and Western medicine could get better therapeutic effect.
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Objective To explore the incidence of facial hormone-dependent dermatitis, and to raise the healing rate of it. Methods We applied non-steroid drug topically, cold compress combined with anti-histamine agents to treat facial hormone-dependent dermatitis in 68 cases. The results were compared before and after the treatment. Results There were significantly clinical effects of non-steroid drug topically, cold compress combined with antihistamine agents on facial hormone-dependent dermatitis, with healing rate of 82. 4 % , and effective rate of 100 %. Conclusions In order to reduce the incidence of facial hormone-dependent dermatitis, we should follow the principal of applying steroid agent strictly to treat facial dermatitis. Meanwhile, there is significantly clinical effects of non-steroid drug with topical use and cold compress combined with antihistamine agents on facial steroid-dependent dermatitis.
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Chemotherapy can induce bone loss. It is especially severe and the incidence of estimated bone loss may be as high as almost 100% for cancer patients treated with anti-sex hormone agents because of inhibition and deficiency of estrogens and/or androgens with the inappropriate ratio of two hormones during and "after therapy. Anti-sex hormone-dependent neoplasm agents-induced bone loss, characterized by an increase of bone turnover rate, should be treated in the early stage in order to prevent it from deterioration and bone fractures. The etiology, mechanism and clinical management of anti-sex hormone-dependent neoplasm agents-induced bone loss are briefly discussed in this review.
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Objective:To investigate the effect of intermittent hormonal therapy(IHT) for patients with different stage/grade prostate cancer(PCa).Methods:The number of cycles and the duration of ON/OFF therapy for 45 PCa patients receiving IHT were observed.Maximal androgen blockade(MAB) the-rapies were used for six to nine months,and then stopped until the serum prostate specific antigen(PSA) was decreased below 0.2 ?g/L,which lasted for three months.It was decided whether MAB went on according to the level of PSA.Results:The average follow-up time was 40.7?13.4 months.Forty-one patients started the second cycle of treatment,of whom,8 became androgen-independent and 7 were at T3-4M0 or M1 stages and the Gleason scores were above 8.Sixteen patients entered the third cycle,of whom,14 were at lower than stage Ⅲ and 13 had the Gleason scores below 7.From the first to the fourth courses of treatment,the average intervals were 8.7?5.4(47.1%),8.4?4.9(49.3%),7.0?3.4(43.7%),and 3.7?0.6(42.5%)months respectively.Five patients developed bone metastasis.No one died up to now.According to the evaluation criteria,patients were divided into tolerance(n=16) and intolerance groups(n=29).Compared with the intolerance group,the patients who tolerated the treatment well had lower Gleason scores(P=0.002),lower PSA levels(P=0.053) and lower tumor stages(P=0.001).There was no evidence that age,lymph node metastasis,bone metastasis and the state of recurrence were associated with an increased risk of the outcome.Non-conditional Logistic regression analysis showed that the proportion of patients at stage Ⅳ was the only independent risk factor for the tolerance of the treatment(OR=12.113,95%CI 1.330-110.312,P=0.027).Conclusion:Intermittent hormonal therapy is more effective and proper for the patient with highly differentiated tumor and at lower stages(≤Ⅲ).The patients who progressed to hormone-independence are mostly at stage Ⅳ with poorly differentiated tumor.Intermittent hormone therapy could be more adaptive for the patients at lower than stage Ⅲ.