RESUMEN
Capillary leak syndrome (CLS) is a clinical syndrome characterized by impairment of vascular endothelial barrier function, increased vascular permeability, and reversible systemic edema. It is one of the early fatal complications after hematopoietic stem cell transplantation. So far, the exact pathogenesis of CLS has not been elucidated, and the diagnostic criteria and treatment methods have not been unified. At present, it is believed that the fundamental cause of CLS is hypercytokinemia, and the core factor is high permeability of vascular endothelial cells. According to the clinical manifestations, the natural course of CLS can be divided into prodrome, leakage and recovery stages. As far as treatment is concerned, symptomatic and supportive treatment is dominant according to different characteristics of each stage. In this review, the pathogenesis, clinical manifestations, diagnosis and treatment of hematopoietic stem cell transplant-associated CLS were briefly summarized.
Asunto(s)
Humanos , Síndrome de Fuga Capilar/diagnóstico , Células Endoteliales , Trasplante de Células Madre Hematopoyéticas/efectos adversosRESUMEN
Severe influenza infection is usually associated with hypercytokinemia ,but the type Ⅰ Interferon remains at low lever or absence.The regulatory mechanism on or the immune escaping mechanism from type I interferon by virus remains to be deter -mined.We briefly summarized the progress in this field and raise several questions to be addressed in the future .