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Objective To explore the clinical significance of early biomarkers in neonatal asphyxia diagnosis with myocardial damage by detection of ischemia modified albumin in neonatal serum(IMA) and glycogen phosphorylase isoenzyme BB(GPBB) for screening sensitive markers with direct myocardial injury.Methods 166 neonates were selected in our hospital as the research object,in which 136 cases with myocardial injury dividend into the experimental group and 30 cases into the control group.The experimental group were divided into mild group and severe group according to the degree of asphyxia.All the children were tested for GPBB and IMA 1 h after admission.Results The levels of GPBB in neonatal asphyxia myocardial injury group and severe asphyxia group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).The sensitivity of GPBB in diagnosis of asphyxia was higher than that of IMA,the difference was statistically significant(P<0.05).Conclusion The degree of asphyxia is closely related to serum IMA,GPBB level in neonatal asphyxia complicated with myocardial injury.The sensitivity and specificity of GPBB in diagnosis asphyxia is better than IMA in children complicated with myocardial damage.
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Objective To investigate the value of serum ischemia-modified protein (IMA),hypersensitivity C reaction protein (hs-CRP),myoglobin (MYO)creatine kinase MB (CK-MB)and ultra-sensitivity troponin T (hs-cTnT)in the early diagnosis of patients with acute coronary syndrome(ACS).Methods Serum levels of IMA,hs-CRP,MYO,CK-MB and hs-cTnT were meaused in 94 patients with ACS[including 40 cases of unstable angina pectoris(UAP),20 cases of non-ST segment elevation myocardial in-farction(NSTEMI),non-Q wave myocardial infarction and 34 cases of ST segment elevation myocardial infarction(STEMI),Q wave myocardial infarction]and 99 cases of controls.The efficiency,sensitivity,specificity,negative and positive predictive values in the early diagnosis of ACS were compared among 5 kinds markers by the ROC curve.Results The detection results of serum IMA,hs-CRP,MYO,CK-MB and hs-cTnT had statistically significant differences between the UAP,NSTEMI and STEMI groups with the normal control group (P 0.05).Conclusion In the patients with ACS,the multiple indicators combined detection can achieve the early diagnostic value.
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Objective To study the significance of serum ischemia modified albumin(IMA) and brain natriuretic peptide(BNP) in patients with acute coronary syndrome. Methods Patients with acute coronary syndrome in six hours were divided into ST elevation myocardial infarction(STEM) of forty one cases, non-ST elevation myocardial infarction( NSTEM)of forty four cases and unstable angina of forty three cases. Twenty healthy people were selected as the control group. The serum IMA and BNP were detected. Results The levels of IMA and BNP in STEM group [(89. 6 ± 21.4) ABSU/ml, ( 324. 6 ± 39. 1 ) ng/L] were significantly higher than those in NSTEM group [( 79. 3 ±20. 5) ABSU/ml, (259. 7 ± 30. 5) ng/L]. The levels of IMA and BNP in NSTEM group were significantly higher than those in UA group[(67. 1 ± 18. 3)ABSU/ml,(124. 1 ±24. 3)ng/L].The levels of IMA and BNP in UA group were significantly higher than those in control group [( 56. 2 ± 15. 1 ) ABSU/ml, ( 15.9 ± 6. 7 ) ng/L]. Conclusion The levels of IMA and BNP in serum could forecast severity in patients with acute coronary syndrome.