1.
Chinese Journal of Biotechnology
;
(12): 16-26, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-310565
RESUMEN
Cofactor balance plays an important role in producing enzymes, pharmaceuticals and chemicals. To meet the demand of industrial production, microbes should maintain a maximal carbon flux towards target metabolites without fluctuations in cofactor. We reviewed the physiological function of cofactor and discussed detailed strategies to manipulate cofactor balance through biochemical engineering and metabolic engineering. Furthermore, we indicated future research needs to further regulate cofactor balance.