RESUMEN
Through the development of close to 30 years,ethics committee has become an indispensable part of biomedical research involving human beings.The research into ethics committee is problem-orientated and has made rich research results from theoretical research to practical research.By using software CiteSpace Ⅲ and analytic visualization of CNKI literature as measuring and drawing tool,this paper made the mapping knowledge domain of ethics committee study since 1991 and found that the published articles amount showed a wave upward trend,the quantity increased sharply in recent years and the research focused on ethical review,clinical trial,informed consent,human subjects,etc.The research topics developed from macro level to micro level and fitted with the development of whole ethical practice.The existing research mainly focused on five aspects of the analysis of laws and regulation,multidisciplinary perspective analysis of ethics committees,the management and practice,the review mechanism and supervision and evaluation.The existing research lacked many summaries accordance with China's national condition;the theory was separate from practice;the research on the micro-level was less.With the development of ethics committee in China,the ethics research on micro-level will become the focus of next step.
RESUMEN
Objective To analyze the developments and frontiers of systemic lupus erythematosus (SLE) research in order to make possible breakthroughs in subsequent studies.Methods Information visualization software Citespace V was applied to draw the mapping knowledge domain based on the database of SLE literature in Science Citation Index Expanded of Web of Science from 1975 to 2016.In this way,it was possible to analyze the basis of knowledge,network relationships between countries or regions,hot spots and courses frontier evolution in the recent 40 years.Results Totally 39 847 articles of literature were collected.The USA,UK,Spain,Italy and Australia were known as the leading countries in the study of SLE.The relationships between SLE and other autoimmune diseases,autoantibody detection and significance,anticardiolipin antibody expression,gene expression,classification criteria,disease activity were hot spots of SLE.Depression of SLE patients,management of SLE and differentiation of SLE were eye-catching research frontiers in recent years.Conclusion The mapping knowledge domain can display the main hot spots in research of SLE,show the frontier spheres and evolution course of related branches of learning,reveal the potential information in complex giant data networks,and guide future studies.