Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Añadir filtros








Intervalo de año
1.
West China Journal of Stomatology ; (6): 157-164, 2023.
Artículo en Inglés | WPRIM | ID: wpr-981107

RESUMEN

OBJECTIVES@#This study aims to explore the therapeutic targets of curcumin in periodontitis through network pharmacology and molecular docking technology.@*METHODS@#Targets of curcumin and periodontitis were predicted by different databases, and the protein-protein interaction (PPI) network constructed by String revealed the interaction between curcumin and periodontitis. The key target genes were screened for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Molecular docking was performed to analyze the binding potential of curcumin to periodontitis.@*RESULTS@#A total of 672 periodontitis-related disease targets and 107 curcumin-acting targets were obtained from the databases, and 20 key targets were screened. The GO and KEGG analyses of the 20 targets showed that curcumin might play a therapeutic role through the hypoxia-inducible factor (HIF)-1 and parathyroid hormone (PTH) signaling pathways. Molecular docking analysis showed that curcumin had good binding potential with multiple targets.@*CONCLUSIONS@#The potential key targets and molecular mechanisms of curcumin in treating periodontitis provide a theoretical basis for new drug development and clinical applications.


Asunto(s)
Humanos , Farmacología en Red , Curcumina/uso terapéutico , Simulación del Acoplamiento Molecular , Periodontitis/tratamiento farmacológico , Medicamentos Herbarios Chinos , Medicina Tradicional China
2.
Genomics & Informatics ; : 96-103, 2016.
Artículo en Inglés | WPRIM | ID: wpr-117341

RESUMEN

The influenza A (H1N1) virus, also known as swine flu is a leading cause of morbidity and mortality since 2009. There is a need to explore novel anti-viral drugs for overcoming the epidemics. Traditionally, different plant extracts of garlic, ginger, kalmegh, ajwain, green tea, turmeric, menthe, tulsi, etc. have been used as hopeful source of prevention and treatment of human influenza. The H1N1 virus contains an important glycoprotein, known as neuraminidase (NA) that is mainly responsible for initiation of viral infection and is essential for the life cycle of H1N1. It is responsible for sialic acid cleavage from glycans of the infected cell. We employed amino acid sequence of H1N1 NA to predict the tertiary structure using Phyre2 server and validated using ProCheck, ProSA, ProQ, and ERRAT server. Further, the modelled structure was docked with thirteen natural compounds of plant origin using AutoDock4.2. Most of the natural compounds showed effective inhibitory activity against H1N1 NA in binding condition. This study also highlights interaction of these natural inhibitors with amino residues of NA protein. Furthermore, among 13 natural compounds, theaflavin, found in green tea, was observed to inhibit H1N1 NA proteins strongly supported by lowest docking energy. Hence, it may be of interest to consider theaflavin for further in vitro and in vivo evaluation.


Asunto(s)
Secuencia de Aminoácidos , Curcuma , Ajo , Zingiber officinale , Glicoproteínas , Esperanza , Técnicas In Vitro , Virus de la Influenza A , Subtipo H1N1 del Virus de la Influenza A , Gripe Humana , Estadios del Ciclo de Vida , Simulación del Acoplamiento Molecular , Mortalidad , Ácido N-Acetilneuramínico , Neuraminidasa , Fitoquímicos , Extractos Vegetales , Plantas , Polisacáridos , Porcinos ,
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA