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Objective To explore the mechanism of motherwort in the treatment of nerve injury. Methods The active components of motherwort were obtained by searching TCMSP and BATMAN-TCM databases. The action targets of candidate compounds were collected and predicted from TCMSP and SwissTargetPrediction (STP) databases. The target genes corresponding to the active components of motherwort were obtained by using the standardized database of disease targets (Uniprot). The potential targets of motherwort in the treatment of nerve injury were obtained by mapping the disease genes of nerve injury with the three databases of Genecards, DisGenet and OMIM. The network topology analysis software Cytoscape 3.6.0 was used to construct the action target network of motherwort active components. The protein interaction platform database (STRING) was used to construct the interaction relationship between action targets. The target protein interaction (PPI) network was constructed by introducing Cytoscape 3.6.0 software. Through STRING database, GO enrichment analysis and KEGG pathway enrichment analysis were carried out to analyze the target points of motherwort in the treatment of nerve injury. Results 19 active components were screened from motherwort, involving 654 action targets, including 426 action targets related to nerve injury and 6 key targets. These target genes were mainly involved in biological regulation, oxidative stress response and cell communication and other biological processes. Molecular functions were mainly related to protein binding, ion binding and catalytic reduction. They were enriched outside the cell membrane. Its mechanism was related to signal pathways such as MAPK, Toll-like receptor, PI3K-Akt, TNF, IL-17, and apoptosis. Conclusion The active components of motherwort may play a protective role on nerve injury through anti-inflammation, anti-apoptosis and promoting cell growth.
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OBJECTIVE: To observe the clinical efficacy of motherwort injection in the treatment of abnormal uterine bleeding-ovulatory dysfunction(AUB-O),and provide data support for broadening the clinical application range of motherwort injection.METHODS: A multicenter,randomized,prospective study was used.The patients who were diagnosed with AUB-O in Hospital of Chengdu University of Traditional Chinese Medicine in 2018 were randomly divided into the control group and the experimental group according to random numbers.There were 75 cases in the experimental group,7 cases were lost,and 68 cases were the final cases;another 75 cases were in the control group,4 cases were lost,and there were 71 cases in the end.In the control group,only the tranexamic acid was given.On the basis of this,the experimental group was given intramuscular injection of motherwort injection 2 mL/time,b.i.d.,for 3 consecutive days.The clinical TCM symptom scores,blood loss,blood routine,coagulation function,endometrial thickness and effective rate were compared between the two groups.All data were statistically analyzed using IBM SPSS 21.0.RESULTS: After treatment,the total effective rate of the experimental group was 97.06%,which was significantly better than that(84.51%)of the control group(P0.05),but on the 2nd day and the 3rd day after treatment,the difference was statistically different(P<0.05),and the cumulative amount of bleeding after 3 days of treatment was statistically different(P<0.05).The endometrial thickness of the experimental group was lower than that of the control group(P<0.01).CONCLUSION: Motherwort injection combined with basic therapy is effective in the treatment of AUB-O.
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OBJECTIVE: To evaluate the efficacy and safety of motherwort(herba leonuri)injection in the treatment of fetal membrane retention after vaginal delivery.METHODS: The prospective study was designed as a multicenter,open,randomized,controlled research from December 2017 to October 2018.A total of 244 women who achieved fullterm vaginal delivery were enrolled from 7 tertiary hospitals in China.Sixteen people were lost to follow-up(7 in the experimental group and 9 in the control group).All cases were randomly divided into group of motherwort(experimental group)and group of basic treatment(control group).Full Analysis Set(FAS)and Per ProtocolSet(PPS)were used for statistical analysis.The results of main validity indicators were the same.Therefore,only the results of PPS set analysis were reported in detail.PPS set included 109 cases in control group and 114 cases in experimental group.Control group were administered by oxytocin 20 U and cephalosporinⅡintravenous injection daily for3 days after birth;experimental group were administered by motherwort 20 mg intramuscular injection per 12 hours for 5 consecutive days on the basis of basic treatment.Both groups of patients were given oral herb medicine Chan-fu-kang or Chan-fu-an Granules after discharge for 7 consecutive days.The following clinical parameters were collected and analyzed for evaluation of the efficacy and safety of motherwort injection in the treatment of retained fetal membrane after vaginal delivery.The main effectiveness indicators were maternal lochia,uterine volume change,and discharge of retained fetal membrane;the secondary effectiveness indicators were the maternal infection-related factors and infections,the incidence of secondary postpartum hemorrhage,postpartum body temperature changes,and the use of other hemostatic drugs.Safety indicators were laboratory tests(blood routine,electrocardiogram),adverse reactions/events,which were used to evaluate the safety and efficacy of motherwort injection in the treatment of retained fetal membrane after vaginal delivery.RESULTS:(1)Lochia:the duration of bloody lochia was significantly shorter in the experiment group than in the control group([(5.12±1.83)d]vs.(6.27±2.07)d,P=0.000);rate of termination of bloody lochia within 5 days was significantly higher in the experiment group than in the control group(64.91% vs. 35.78%,P=0.000).(2)Comparison of uterine volume:the reduction of uterus volume in the experiment group was significantly greater than that in the control group(Z=-2.27,P8.0 mg/L or PCT>0.5 ng/L was defined as infection,the infection rate of the experiment group after 5 days of treatment was significantly lower than that of the control group(P0.05).No other hemostatic drugs were used in the two groups,and no secondary postpartum hemorrhage occurred.(6)There were no adverse reactions reported in both groups,and no abnormal blood routine indicators or electrocardiogram appeared.CONCLUSION: The application of motherwort injection combined with the basic treatment after the vaginal delivery can significantly shorten the duration of bloody lochia,promote uterine involution,increase the discharge rate of retained fetal membrane,and reduce the rate of uterine curettage.
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Objective To study the effects of modified Shenghua decoction combined with motherwort granules in treatment of postpartum placenta remnants.Methods136 selected patients with postpartum placenta remnants admitted into the hospital from June 2015 to October 2016 were divide into control group (68cases) and research group (68 cases).Control group was given motherwort granules and research group took modified Shenghua decoction on the basis of control group.The changes of endometrial thickness, residual area of placenta, TCM symptom scores, level of human chorionic gonadotropin (β-HCG), survival quality scores, menstruation recovery time, vaginal bleeding duration, cure time, occurrence of adverse reactions of two groups before and after treatment were compared, and efficacy of two groups were evaluated.ResultsAfter treatment, there was statistical difference in the endometrial thickness, residual area of placenta, TCM symptom scores, β-HCG level, survival quality scores, pain scores compared between the two groups (P<0.05);The menstruation recovery time, vaginal bleeding duration, cure time of research group were significantly lower than those of control group (P<0.05);There was statistical difference in the clinical efficacy compared between the two groups (P<0.05);There was no statistical difference in the incidence of adverse reactions between the two groups.ConclusionModified Shenghua decoction soup combined with motherwort granules for treating patients with postpartum placenta remnants can effectively relieve clinical symptoms, increase efficacy, reduce patients' pain, promote their recovery and improve survival quality, which has significant clinical advantages and can be further generalized and applied.
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Objective To investigate the clinical effect of psychological intervention combined with fresh motherwort capsule in the treatment of postpartum lochiorrhea and waist pain. Methods 86 cases of postpartum lochiorrhea and waist pain patients admitted to our hospital from January 2016 to December 2016 were selected. The patients were divided into observation group and control group according to the random number table method, 43 cases in each group. The control group was treated with routine nursing combined with the treatment of uterine stopping granule, while the observation group was treated with psychological intervention combined with the fresh motherwort capsule. After 1 month of intervention, the postoperative morbidities (the amount of lochia, the duration of lochia, the blood, and the bloody) and the abdominal pain and the condition of anxiety and depression before and after treatment were statistically compared between the two groups. Results Two groups of lochia status and waist pain were compared before treatment, and there was no statistically significant difference; After 1 month of intervention, the postoperative morbidities (the amount of lochia, the duration of lochia, the blood, the bloody) and the scores of abdominal pain in the observation were lower than those in the control group. And there was statistically significant difference; After 1 month's intervention, the anxiety and depression scores of the observation group were lower than that of the control group; the difference was statistically significant (P<0.05). Conclusion The treatment of psychological intervention combined with fresh motherwort capsules can reduce postpartum lochia amount of bleeding, shorten the duration of lochia, reduce abdominal pain, improve patient's psychological state, and promote postpartum recovery.
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Objective To analysis the fresh motherwort capsule treatment of postpartum uterine hemorrhage clinical value.Methods100 cases of postpartum uterine hemorrhage patients of our hospital from January 2016 to December 2016 were selected as the research object, the control treatment, use contractions observed group of using fresh motherwort capsule combined contractions for treatment.Check after drug treatment in patients with uterine instauration and clinical curative effect.ResultsAfter five days, two groups of patients with postpartum uterine instauration is close, there was no statistically significant difference.After 14 days, observation group of patients with uterine instauration was significantly better than the control group, there was statistically significant difference (P< 0.05);Observation group of patients treatment of cure rate (76.0%), and total effective rate (96.0%) were significantly higher than control group (56.0%, 88.0%), statistically significant difference (P< 0.05).ConclusionFresh motherwort capsule in the treatment of postpartum uterine hemorrhage has significant clinical efficacy, can promote the patients with uterine instauration, has significant clinical value, worthy of popularization and application.
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Objective To investigate the the effect of motherwort on metalloproteinases in decidual tissue in the treatment of abnormal uterine bleeding induced by drug abortion in patients.Methods 76 patients with abnormal uterine bleeding by drug abortion in this study form Cangnan County Maternity & Child Healthcare Hospital were selected and divided into 2 group, 38 cases of each group.The control group received mifepristone, misoprostol and progynova treatment,the experimental group received more with motherwort.The serum hormones change and matrix metalloproteinases in decidual tissue by S-P method were determine,while adverse reaction were compared after the treatment.Results Compared with before treatment,levels of serum estradiol increased,progesterone decreased,content of the matrix metalloproteinase(MMP-3)and MMP-9 in decidual tissue increased,tissue inhibitor of metalloproteinase(TIMP-1)in decidual tissue decreased,the differences were statistically significant(P<0.05),compared with the control group,levels of serum estradiol in the experimental group were higher,progesterone were lower,contents of MMP-9 and MMP-3 in the tissues were higher, levels of TMP-1 were lower, and bleeding duration was shorter, vaginal bleeding was less ( P <0.05 ) .Conclusion Motherwort in the treatment of abnormal uterine bleeding by drug abortion in patients has good curative effect,it could increase the levels of MMP-3 and MMP-9,reduce levels of TIMP-1 in decidual tissue,and reduce the bleeding time and bleeding volume.
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Objective To investigate the carboprost ammonia butyl alcohol three plus motherwort injection on prevention of high risk maternal postpartum hemorrhage effect .Methods 120 cases of cesarean section operation and potential bleeding symptom of women were selected as the research object ,and randomly divided into two groups , the observation group of 60 cases using carboprost ammonia butyl alcohol three joint of leonurus heterophyllus injec -tion for prevention and treatment ,the control group of 60 cases used oxytocin for prevention and treatment ,prevention and treatment effects were compared between the two groups .Results After treatment,the observation group 2h,24h postpartum hemorrhage were (422.41 ±213.49)mL,(35.29 ±16.44)mL,were significantly less than those in the control group (589.64 ±345.21)mL,(69.31 ±29.47)mL(t=6.732,8.915,all P<0.05);the observation group 1 cases without production after bleeding ,control group 5 cases of postpartum hemorrhage ,statistically significant differ-ences between the two groups (χ2 =4.973,P<0.05).Conclusion Carboprost ammonia butyl alcohol three plus motherwort injection on prevention of high risk maternal postpartum hemorrhage has a significant effect ,which can re-duce the cesarean section uterine bleeding and reduce the amount of bleeding ,promote uterine involution ,conducive to maternal rehabilitation .
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ObjectiveTo analyze the impact of combined use of motherwort injection with oxytocin on hemorrhage in cesarean section and postoperative stage.Methods512 pregnant women after processing cesarean section were randomly divided into an experimental group (n=256) and a control group (n=256).The experimental group used motherwort injection and oxytocin,and the other group only used oxytocin.Intraoperative and postoperative bleeding and adverse drug reactions were observed.ResultsBleeding volume in the experimental group was less than the control group [ (210.43 ± 50.38)ml,(35.84 ±29.24)ml,(61.62 ±35.32) ml vs (234.14 ±16.91) ml,(52.37 ± 32.15) ml,(86.18 ± 36.67) ml],P＜0.05).There were no significant adverse reactions.ConclusionMotherwort injection and oxytocin used together can be more effective in reducing bleeding in cesarean section and postoperative stage.
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Objective To explore the curative effects of treating vaginal bleeding after drug-induced abortion with self-made biochemical mixture. Methods A total of 100 pregnant patients were randomly recruited into a control group and a treatment group. Both groups were treated with mifepristone and misoprostol. On this basis, the control group was administrated with Motherwort herb preparation orally, and the treatment group was treated with self-made biochemical mixture orally. Both groups were treated for 7 days. Therapeutic effects were observed after the treatment. Results The total effective rate was 76% and 94% in the control group and the treatment group respectively, showing statistical difference (χ2=8.663, P＜0.05).Conclusion It is effective to treat vaginal bleeding after drug-induced abortion with self-made biochemical mixture.
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Objective To estblish a HPLC method for content determination of ferulic acid in compound prescribe Motherwort Herb capusle. Method The column ZORBAXSB-C18 was used with Acetonitrile-0.2% phosphoric acid aqueous solution (12∶88) as mobile phase, and detective wavelength was 274 nm, the flow rate was 1.0 mL/min. Result Within the range of 0.8～13 ?g, ferulic acid presented a fine linear relationship (r =0.999 99, n =6). The average recovery was 103.0% (RSD=0.4%, n=5). Conclusion The method is suitable, accuracy is high and reproducibility is good, recovery is high, and can control the quality of compound prescribe Motherwort Herb capusle.
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Objective:To compare the curative effect of uterine body oxytocin injection and motherwort with oxytocin on preventing the cesarean and postpartum hemorrhage and promoting the involution of uterus.Methods:160 cases of cesarean inpatients were randomly divided into the experimental and controlled groups respectively.All the cesarean patients accepted their lower uterine segment transverse caesarean section within the fascia.The controlled group got the uterine body injection of 10 units of oxytocin after the fetus was delivered,and then got another 10 units of intramuscular oxytocin injection,every 12 hours at a time,totally 6 times.The experimental group got their extra uterine body injection of 20mg motherwort,and then got another 20mg of intra-muscular motherwort injection,every 12 hours at a time,totally 6 times.The volume and case of puerperal and postpartum hemorrhage and involution of uterus were observed.Results:The comparison showed that the volume and cases of puerperal and post-natal 2-hour and post-natal 24-hour hemorrhage of the experiment group were significandy fewer than those of the controlled group,(P
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The motherwort is a long-standing used herb, especially treatment for gynaecological diseases and many other effects: brought out some science problems about traditional and western medicine that it's not unify such as what type of herbs has effects? using young or older herbs? using while tree or only using top of tree? how efficacy of herb? what kind of herbs can combine with it? and other effects can pay attention to. The author hopes that the motherwort will be further investigated