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No abstract available.
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Solitary fi brous tumor (SFT) is a rare soft-tissue neoplasm which may occur at any site although it is more frequent in the pleura, mediastinum and lung. Orbital involvement by SFT is uncommon. Giant cells are extremely rare to be seen in a SFT and have been described to be immunoreactive for CD34. We present a case of orbital SFT with multinucleate giant cells expressing CD68 and lacking immunoreactivity for CD34. The differential diagnosis is discussed.
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Although inhibitory mechanisms that safeguard cells against DNA damages occur in all cells, genetic instability is widely present throughout living world. Some well known viruses cause alterations in host genome, leading to the formation of malignant transformations. Throughout this review we discuss some forms of instabilities caused by herpes simplex virus. Herpes simplex virus may induce chromosomal instabilities by various mechanisms, such as by formation of syncytium or ICP0-induced degradation of constitutive centromere proteins as well as may induce accumulation of point mutations by means of oxidative stress in neurons. We believe that further investigation of the ability of herpes simplex virus to cause genetic instability may help us to increase our understanding about the nature of this phenomenon.
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Anthers of two soybean cultivars were cultured in B5 long basal culture media gelled with agarose or PhytagelTM. Cytological examinations of the anthers were carried out during the first 45 days of culture to assay the viability and developmental stage of microspores. Frequency of callus formation was recorded at 45 days of culture. The analysis of variance of the microspore viability assay showed significant Cultivar X Gelling Agent X Day of Culture interactions. The frequencies of viable microspores decreased significantly with time of culture, within each cultivar and gelling agent tested. The interaction Day X Cultivar was significant for the frequencies of binucleate symmetrical grains and multinucleate/multicellular structures. The effect of gelling agents on the frequency of binucleate symmetrical pollens grains and multinucleate/multicellular structures was not significant. About the frequencies of calli and embryogenic calli formed, a significant difference was detected between the cultivars (IAS5= 14.8 percent and BRS 133=6.6 percent). Gelling agents showed no effect over these frequencies.
Anteras de duas cultivares de soja foram cultivadas em meio de cultura basal B5 longo gelificado com agarose ou Phytagel®. Análises citológicas das anteras foram conduzidas durante os primeiros 45 dias de cultura para avaliar a viabilidade e o estágio de desenvolvimento dos micrósporos. A freqüência de formação de calos foi analisada após 45 dias do início da cultura. A análise da variância da viabilidade do micrósporo mostrou interações significativas de Cultivar X Agente Gelificante X Dias de Cultura. As freqüências de grãos de pólen viáveis diminuíram significativamente com o tempo de cultura, dentro de cada cultivar e agente gelificante testado. A interação Dia X Cultivar foi significante para as freqüências de grãos de pólen binucleados simétricos e estruturas multinucleados/multicelulares. O efeito do agente gelificante na freqüência de grãos de pólen binucleados simétricos e estruturas multinucleados/multicelulares não foi significante. Com relação às freqüências de calos e estruturas embriogênicas formadas, houve diferença significativa entre cultivares (IAS5= 14.8 por cento e BRS 133=6.6 por cento). O agente gelificante não mostrou efeito em tais freqüências.
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Multinucleate cell angiohistiocytoma (MCAH) is a rare benign fibrohistiocytic vascular condition that usually occurs on the extremities of elderlies women as discrete, grouped, red-brown papules and coalescing plaques. MCAH is characterized histologically by dermal vascular proliferation, bizarre multinucleate cells, and a sparse lymphohistiocytic infiltrate. Herein, we report a 61-year-old man presented with an asymptomatic 1.6x3.3cm sized, erythematous verrucous plaque under the left lower eyelid for 5 months. Histopathologic examination revealed variable-sized, proliferative, dilated dermal vessels lined by plump endothelial cells and interspersed multinucleated cells among these vascular channels. Multinucleated cells were positive only for vimentin, but negative for S-100 protein and Factor VIII related antigen.
Asunto(s)
Femenino , Humanos , Persona de Mediana Edad , Células Endoteliales , Extremidades , Párpados , Proteínas S100 , Vimentina , Factor de von WillebrandRESUMEN
Multinucleate cell angiohistiocytoma is a rare benign fibrohistiocytic vascular condition with distinctive histologic features. It tends to occur more frequently in middle-aged women, to favor the extremities, and to appear as grouped reddish-brown papules. We describe a case of solitary multinucleate cell angiohistiocytoma that appeared as a papule on the upper lip of a 24-year-old man.