RESUMEN
The brain communicates with the metabolic dependent pathway and the immune pathway of the sympathetic nervous system(SNS), and participates in the Brain-Kidney axis to a certain extent. In the course of chronic kidney disease,nervous system diseases,such as cerebrovascular disease, cognitive impairment and neuropathy,occur frequently, which indicates that there are a lot of crosstalk between kidney and brain. In this paper, the pathophysiological mechanism of BrainKidney dialogues in chronic kidney diseases is discussed from the point of nutrient metabolism in patients with chronic kidney diseases, and the two-way regulation mechanism of humral and non-humoral pathays was also studied,which is affected by microvascular and white matter lesions, homocysteinemia, disturbance of hormone and neurotransmitter regulation, immune inflammation and sympathetic nervous system,in order to provide more effective strategies for optimizing protein nutrition and improving prognosis by further understanding the causes and pathogenesis of nutritional metabolic disorders in patients with chronic kidney disease and end-stage renal disease.