Research progress on the regulation of phenolic compounds of traditional Chinese herbs on oral microbes / 华西口腔医学杂志

Phenolic compounds are widely found in natural Chinese medicinal plants and have excellent pharmacological properties, such as antioxidation and anti-inflammation. They are the main pharmacological components of many medicinal Chinese herbs. Oral microbiota, especially its composition and metabolism, is highly related to the balance of oral microecology and plays a key role in the occurrence and development of oral diseases. Recent studies have shown that phenolic compounds of traditional Chinese herbs can prevent and treat oral diseases, such as caries, periodontal disease, and oral mucosal infection, by regulating the composition, metabolites, and virulence of oral microorganisms. This review will summarize and discuss the regulation of phenolic compounds on oral microbes.

Research progress on the relationship between oral microbes and digestive system diseases / 华西口腔医学杂志

The human microbiome project promoted further understanding on human oral microbes. Besides oral diseases such as dental caries, periodontal disease, and oral cancer, oral microbes are closely associated with systematic diseases. They have a close connection with digestive system diseases and even contribute to the origination and progression of colorectal cancer. By reviewing recent studies involving oral microbe-related digestive systemic diseases, we aim to propose the considerable role of oral microbes in relation to digestive systemic diseases and the way of oral microbes to multiple organs of digestive system.

Comparison of Antimicrobial Activity of Electrolyzed Water Using Various Electrodes against Biofilm of Oral Pathogens

Biofilms of oral microbes can cause various diseases in the oral cavity, such as dental caries, periodontitis and mucosal disease. Electrolyzed water generated by an electric current passed via water using a metal electrode has an antimicrobial effect on pathogenic bacteria which cause food poisoning. This study investigated the antimicrobial activity of electrolyzed waters using various metal electrodes on the floatage and biofilms of oral microbes. The electrolyzed water was generated by passing electric current using copper, silver and platinum electrodes. The electrolyzed water has a neutral pH. Streptococcus mutans, Porphyromonas gingivalis and Tannerella forsythia were cultured, and were used to form a biofilm using specific media. The floatage and biofilm of the microbes were then treated with the electrolyzed water. The electrolyzed water using platinum electrode (EWP) exhibited strong antimicrobial activity against the floatage and biofilm of the oral microbes. However, the electrolyzed water using copper and silver electrodes had no effect. The EWP disrupted the biofilm of oral microbes, except the S. mutans biofilm. Comparing the different electrolyzed waters that we created the platinum electrode generated water may be an ideal candidate for prevention of dental caries and periodontitis.

Laboratorial evaluation of antimicrobial efficacy of herbal dentifrices commercialized in India / Avaliação laboratorial da eficácia antimicrobiana de dentifrícios herbais comercializados na Índia

Objective: The purpose of this in vitro study to evaluate antimicrobial efficacy of commercially available herbal dentifrices in comparison with conventional dentifrices against seven oral microbes, namely, Streptococcus mutans, Streptococcus mitis, Streptococcus sanguinis, Streptococcus salivarius, Actinomyces viscosus, Candida albicans, and Lactobacillus acidophilus. Materials and methods: Antimicrobial properties of dentifrices were evaluated by measuring zone of inhibition at 48h on blood agar plates inoculated with microbial strains, using disc diffusion method. Each dentifrice was tested in 100% and 50% concentration. Sterile distilled water was used as control. One way Analysis of Variance followed by Tukey post hoc was used for multiple group comparisons. P value < 0.05 was considered statistically significant. Results: In both, 100% and 50% concentrations maximum zone of inhibition was observed with Smyle™ herbal toothpaste followed by Himalaya herbals™ dental cream. Conclusion: Antimicrobial activity of Smyle™ herbal toothpaste is the best against microorganisms tested in present study.

Objetivo: O propósito deste estudo foi avaliar e comparar a eficácia antimicrobiana de dentifrícios herbaiscomerciais e convencionais contra sete micro-organismos: Streptococcus mutans, Streptococcus mitis, Streptococcus sanguinis, Streptococcus salivarius, Actinomyces viscosus, Candida albicans, and Lactobacillusacidophilus. Materiais e métodos: Propriedades antimicrobianas dos dentifrícios foram avaliadas a partir damedição da zona de inibição utilizando o método de difusão em disco após 48h em placas de ágar sangue inoculadascom as cepas microbianas. Cada dentifrício foi testado nas concentrações de 100% e 50%. O controleconsistiu em água destilada estéril. As comparações entre grupos foram realizadas por ANOVA a um critério eteste de Tukey post hoc, ambos com nível de significância de 5%. Resultados: Em ambas as concentrações de100% e 50%, a zona de inibição máxima foi observada para o dentifrício herbal Smyle® seguido do dentifrícioherbal Himalaya herbals®. Conclusões: O dentifrício herbal Smyle® apresentou o melhor resultado contra osmicro-organismos avaliados no presente estudo.