Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology / 药学实践杂志

Objective To prepare Herba Cistanche enteric release microspheres, optimize the preparation process and study the releasing characteristics of microspheres in vitro.Methods Ion gelatin-oven drying method was used to prepare Herba Cistanche enteric microspheres.The preparation process was optimized with the aid of a Box-Behnken design.Results The optimal preparation condition was 36.33 mg/ml of sodium alginate, 10.82 mg/ml of calcium chloride and 10.93 mg/ml of chitosan.Conclusion This technology is repeatable and feasible.The microspheres have high entrapment efficiency and good sustained release characteristics.

Effects of Different Drying Methods on Total Saponin Content and Antioxidant Capacity of Paris polyphylla var.yunnanensis / 中国中医药信息杂志

ObjectiveTo study the effects of 9 different drying methods on total saponin content and antioxidant capacity ofParis polyphylla var.yunnanensis.Methods UV-VIS spectrophotometry was used for measuring the total saponin content ofP. polyphylla var.yunnanensis, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzthiozoline-6)-sulphonic acid (ABTS+) radical scavenging methods were used for evaluating the antioxidant capacity ofP. polyphylla var. yunnanensisextracts.ResultsThe total saponin contents ofP. polyphylla var.yunnanensis dried by different methods existed significant difference. The sample dried at 35℃ showed highest total saponin content (17.557 mg/g). The sample dried in the shade naturally showed middle total saponin content (13.740 mg/g). Based on the results of antioxidant capacity detected by two methods, the samples ofP. polyphylla var. yunnanensis dried by 9 different methods all showed good antioxidant capacity and showed a certain concentration dependence.Conclusion The samples dried at 35℃ have the highest antioxidant capacity. Therefore, drying at 35℃ is a better drying method to obtain high quality and high activity ofP. polyphylla var.yunnanensis.

Influence of Nelumbinis Receptaculum from different regions and picking times on content of proanthocyanidins / 中草药

Objective: To study the contents of proanthocyanidins in Nelumbinis Receptaculum (NR) obtained from the different regions and harvest times, so as to determine the appropriate harvest times and proper planting regions of NR as well as provide the support for the reasonable use of NR. Methods: Twelve regions and six different harvest periods in Zhejiang were collected and the contents of proanthocyanidins were determined by UV spectrophotometry. Results: Maturity had great influence on the contents of proanthocyanidins, The mature had much more proanthocyanidins than the young. Different drying methods had influence on the contents of proanthocyanidins, among which oven drying method has the least influence, followed by drying in the shade, then suning method has the most influence. There was a certain difference in the contents of proanthocyanidins in NR from the different regions and harvest times with a characteristic interval fluctuations. Conclusion: Mature NR should be collected consistent with lotus seeds, the NR should be dried in dryer or in shade, avoid exposing to the sun. The contents of proanthocyanidins in NR from different regions and picking times change in the variation range of 6% to 8%. Wide origin places have been demonstrated suitable to providing the raw materials for industrial production and NR collection is appropriate from the middle of July to September.