Tratamiento combinado de catgutpuntura y ozonoterapia en la psoriasis vulgar. Hospital Clínico Quirúrgico Lucia Íñiguez Landín. 2019- 2021

Fundamento: la psoriasis afecta aproximadamente al 2 % de la población mundial, con amplias repercusiones biopsicosociales. Objetivo: determinar la efectividad del tratamiento combinado catgutpuntura-ozonoterapia en los pacientes con psoriasis vulgar. Métodos: estudio cuasiexperimental de intervención del tipo antes y después sin grupo de control realizado en el Hospital Lucia Íñiguez Landín, en el período abril 2019 a 2021. La población estuvo constituida por 55 pacientes; la muestra quedó conformada por 29 que cumplieron con los criterios de inclusión. Se realizó un análisis multivariado de frecuencias absolutas y relativas. Para evaluar la efectividad del tratamiento se utilizó la prueba estadística de diferencia de proporciones con un nivel de confianza de 95 %, considerándose estadísticamente significativa. Resultados: predominó el sexo femenino y el grupo de edad de 40 a 49 años. Los síndromes de insuficiencia del Yin de riñón y Xue de hígado constituyeron los más representativos. Se logró disminuir la severidad de la enfermedad en casi la totalidad de estos. Las reacciones adversas a las terapias empleadas fueron mínimas. Conclusiones: el tratamiento combinado fue considerado parcialmente efectivo.

Background: psoriasis affects approximately 2 % of the world population, with extensive biopsychosocial repercussions. Objective: to determine the effectiveness of the combined catgutpuncture-ozone therapy treatment in patients with psoriasis vulgaris. Methods: quasi-experimental intervention study of the type before and after without a control group carried out at the Lucia Íñiguez Landín Hospital, from April 2019 to 2021. 55 patients were the population; 29 patients were the sample who met the inclusion criteria. A multivariate analysis of absolute and relative frequencies was performed. To evaluate the effectiveness of the treatment, the statistical test of proportions' difference was used with a confidence level of 95%, being considered statistically significant. Results: the female sex and the age group of 40 to 49 years old predominated. Kidney Yin and liver Xue insufficiency syndromes was the most representative. It was possible to reduce the severity of the disease in almost all of them. Adverse reactions to the therapies used were minimal. Conclusions: the combined treatment was considered partially effective.

Ozonoterapia y cáncer: mito o realidad / Ozone Therapy and Cancer: Myth or Reality

Introducción: El uso clínico de la ozonoterapia se incrementa cada día. Abarca disímiles especialidades médicas como la oncología. En Cuba las investigaciones que evalúan el empleo de la ozonoterapia en pacientes con cáncer son escasas, se precisan estudios científicos que demuestren su eficacia clínica. Objetivo: Explicar los mecanismos farmacológicos y bioquímicos de la ozonoterapia y su uso en el cáncer como terapia complementaria. Métodos: Se consultaron bases de datos disponibles a través de la red de Infomed. Se utilizaron como palabras clave: cáncer, ozonoterapia y estrés oxidativo. Se seleccionaron artículos originales y de revisión sistemáticos de los últimos diez años que evaluaron la utilización de la ozonoterapia en el tratamiento del cáncer. Resultados: El cáncer es per se una enfermedad inductora de estrés oxidativo. La ozonoterapia respalda su utilización como una terapia adyuvante mediante el preacondicionamiento oxidativo que estimula los sistemas antioxidantes de la célula contra la acción de los radicales libres. Así, se logra neutralizar la acción nociva del estrés oxidativo. El ozono incrementa la eficacia de la radio - quimioterapia y ayuda a reducir los efectos secundarios de estos tratamientos al activar los sistemas antioxidantes de la célula. La ozonoterapia se caracteriza por la simplicidad de su aplicación, bajos costos, alta efectividad y prácticamente ausencia de efectos colaterales en comparación con otros tratamientos adyuvantes. Conclusiones: El uso de la ozonoterapia en oncología como una terapia adyuvante representó un recurso terapéutico de gran valor dado por su perfil de efectividad y seguridad. Su uso podría extenderse para disminuir los efectos secundarios y mejorar la calidad de vida de los pacientes(AU)

Introduction: The clinical use of ozone therapy is increasing every day worldwide and it covers different medical specialties, including oncology. However, in Cuba, the investigations that evaluate the use of ozone therapy in cancer patients are scarce, so scientific studies are needed to demonstrate its clinical efficacy. Objective: To explain the pharmacological and biochemical mechanisms of ozone therapy and its use in cancer as a complementary therapy. Methods: Databases available through Infomed Network were consulted. Key words used were cancer, ozone therapy and oxidative stress. Original and systematic review articles from the last ten years that evaluated the use of ozone therapy in the treatment of cancer were selected. Results: Cancer is, as such, a disease that induces oxidative stress. Ozone therapy supports its use as an adjuvant therapy through oxidative pre-conditioning that stimulates the cell's antioxidant systems against the action of free radicals. Thus, it is possible to neutralize the harmful action of oxidative stress. Ozone increases the efficacy of radio-chemotherapy and helps reducing the side effects of these treatments by activating the cell's antioxidant systems. Ozone therapy is characterized by the simplicity of its application, low costs, high effectiveness and with practically no side effects, compared to other adjuvant treatments. Conclusions: The use of ozone therapy in oncology as an adjuvant therapy represented a therapeutic resource of great value given its effectiveness and safety profile. Its use could be extended to improve tissue oxygenation and thus enhance the efficacy of radiochemotherapy, reducing side effects and improving the patients's quality of life(AU)

Ozonated triglyceride protects against septic lethality via preventing the activation of NLRP3 inflammasome / 中南大学学报(医学版)

OBJECTIVES@#Sepsis is a critical dysregulated host response with high mortality and current treatment is difficult to achieve optimal efficacy. Ozone therapy has been revealed to protect infection and inflammation-related diseases due to its role in antibiotic and immunoregulatory effect. Ozonated triglyceride is a key component of ozonated oil that is one of ozone therapy dosage form. However, the potential role of ozonated triglyceride in sepsis remains unclear. This study aims to explore the effect of ozonated triglyceride on septic mouse model and the molecular mechanism.@*METHODS@#Intraperitoneal injection of lipopolysaccharide (LPS), cecal ligation and puncture (CLP) were applied to construct septic mouse model. The mouse serum was obtained for detection of cytokines, and lung tissues were collected for hematoxylin and eosin (HE) staining to evaluate the extent of lung injury in septic mouse with ozonated triglyceride treatment at different time and doses. The survival of septic mice was observed for 96 h and Kaplan-Meier analysis was used to analyze the survival rates. In addition, primary peritoneal macrophages and human acute monocytic-leukemia cell line (THP-1) were treated with inflammasome activators with or without ozonated triglyceride. The level of cytokines was detected by enzyme-linked immunosorbent assay (ELISA). The cleavage of caspase-1 and gasdermin-D (GSDMD) was detected by Western blotting.@*RESULTS@#Ozonated triglyceride at different time and doses reduced the release of inflammasome-related cytokines [interleukin (IL)-1β and IL-18] (all P<0.05) but not pro-inflammatory cytokines such as IL-6 and tumor necrosis factor-α (TNF-α) in septic mice (all P>0.05). Ozonated triglyceride significantly improved the survival rate of septic mice and reduced sepsis-induced lung injury (all P<0.05). Ozonated triglyceride significantly suppressed the canonical and non-canonical activation of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome (all P<0.05) but not affected absent in melanoma 2 (AIM2) and NLR family CARD domain-containing protein 4 (NLRC4) inflammasomes in vitro (all P>0.05). Ozonated triglyceride reduced the cleavage of caspase-1 and the downstream GSDMD.@*CONCLUSIONS@#Ozonated triglyceride presents a protect effect on sepsis lethality via reducing cytokines release and sepsis-related organ injury. The mechanism is that ozonated triglyceride specifically suppresses the activation of NLRP3 inflammasome. Ozonated triglyceride is a promising candidate for sepsis treatment.

Potencialidades terapéuticas de la ozonoterapia en el Instituto de Hematología e Inmunología / Therapeutic potentialities of Ozone-therapy in the Hematology and Immunology Institute Sobre los autores:

La ozonoterapia permite aprovechar las reacciones del ozono con moléculas del organismo para inducir efectos biológicos deseados facilitando su empleo en el tratamiento de diferentes afecciones, incluidas las sepsis y el cáncer. El objetivo de este trabajo es describir brevemente las acciones atribuidas al empleo terapéutico del Ozono medicinal para incorporarlo a nuestros esquemas de tratamiento. Mediante la revisión de trabajos recientes que tratan el tema, se recopiló esta información que nos condujo a concluir que el uso del ozono médico, en las dosis adecuadas, es ventajoso en el tratamiento de los pacientes que se atienden en la institución(AU)

The Ozone-therapy allows using the potential of ozone reactions with body molecules in order to obtain a desired biological effect treating diseases as cancer and infection. The aim of this work is to shortly describe the attributable actions of therapeutic use of medicinal ozone to put it into the treatment schemes. By means of reviewing recent issues about the topic there was compiled the information that permits to conclude that usage of medical ozone, in appropriated dose, is an advantage in treatment of patients in the institute(AU)

Is Ozone therapy an adjunct treatment for SARS-CoV-2 / COVID-19 infection?

Abstract Up to today, there is no specific treatment against SARS-CoV-2 / COVID-19 infection; there the necessity to search for alternatives that help patients with COVID-19. The objective of this study was to review the use of ozone therapy as adjunct treatment for SARS-CoV-2 / COVID-19 infection, highlighting the mechanisms of action, forms of application and current clinical evidence. A systematic review was conducted in electronic databases, searching the terminology Ozone "or" Ozone therapy "and" SARS-CoV-2 or COVID-19 or Coronavirus. Results: nineteen studies were included; ten were editorials, comments, brief reports or reviews, and nine clinical studies. We found that ozone therapy could be favorable for treating patients infected with SARS-CoV-2 / COVID-19, through a direct antiviral effect, regulation of oxidative stress, immunomodulation and improvement of oxygen metabolism. Patients who were treated with ozone therapy responded favorably; therefore, ozone therapy appears to be a promising treatment for patients infected with SARS-CoV-2 / COVID-19. Its mechanism of action justifies its use as an adjuvant therapy; however, scientific evidence is based on case series and clinical trials are necessary to corroborate its effectiveness and safety.

Ozonoterapia en pacientes con dolor pélvico crónico / Ozone therapy in patients with chronic pelvic pain

Introducción: La factibilidad y seguridad del empleo de la ozonoterapia se evidencia en los resultados expuestos por varios autores, en enfermedades cuyo síntoma fundamental es el dolor crónico. Objetivo: Determinar la evolución clínica de las pacientes con dolor pélvico crónico, tratadas con ozono asociado al tratamiento médico convencional. Métodos: Estudio descriptivo, observacional, retrospectivo, en el que se determinó la evolución clínica de las pacientes con dolor pélvico crónico tratadas con ozono, asociada al tratamiento médico convencional. La muestra fue de 54 mujeres. Las variables utilizadas fueron: edad, causa del dolor pélvico, tiempo de evolución, puntuación de la escala de dolor antes y después de la aplicación de la ozonoterapia y evaluación del tratamiento. Resultados: Prevalecieron las pacientes con edad de 26-35 años. El 57,4 por ciento tenían entre 2 y 2 años de evolución del dolor. La enfermedad inflamatoria pélvica crónica fue la causa de mayor frecuencia con 42,5 por ciento. Antes de la aplicación de la ozonoterapia la media de puntuación en la escala de dolor fue de 6,31, y disminuyó a 3 después del tratamiento, con una evaluación de bien en el 81,1 por ciento de los casos. Conclusiones: Después de la aplicación de la ozonoterapia asociada al tratamiento médico convencional, se produce mejoría clínica, por lo que puede ser una alternativa de tratamiento(AU)

Introduction: The feasibility and safety of the use of ozone therapy is evidenced in the results presented by several authors, in diseases whose main symptom is chronic pain. Objective: To determine the clinical evolution of patients with chronic pelvic pain treated with ozone associated with conventional medical treatment. Methods: Descriptive, observational, retrospective study, in which the clinical evolution of patients with chronic pelvic pain treated from January 2018 to January 2020, with ozone therapy, associated with conventional medical treatment. The sample was 54 women. The variables used were: age, cause of pelvic pain, time of evolution, score on the pain scale before and after the application of ozone therapy, and evaluation of the treatment. Results: Patients aged 26-35 years prevailed. 57,4 percent had between two and four years of pain evolution. Chronic pelvic inflammatory disease was the most frequent cause with 42,5 percent. Before the application of ozone therapy, the mean score on the pain scale was 6.31, and it decreased to 3 after treatment, with an evaluation of good in 81,1percent of the cases. Conclusions: After the application of ozone therapy associated with conventional medical treatment, there is evident clinical improvement, which is why it constitutes an alternative of treatment(AU)

Efectividad de ozonoterapia en tratamiento de gingivitis en adolescentes, Pinar del Río 2019 / Effectiveness of ozone-therapy in the treatment of gingivitis in adolescents, Pinar del Rio 2019

RESUMEN Introducción: el ozono por su amplia gama de propiedades es útil para tratar afecciones bucales como la gingivitis crónica. Objetivo: demostrar efectividad de la ozonoterapia en el tratamiento de la gingivitis crónica en adolescentes en el Policlínico "Pedro Borrás Astorga", del municipio Pinar del Río, en el período comprendido entre enero y septiembre de 2019. Métodos: se realizó un estudio observacional, analítico, longitudinal, de casos y control. La muestra quedó conformada por 50 pacientes seleccionados por el método no probabilístico intencionado, teniendo en cuenta los criterios de inclusión y exclusión. Para un mejor estudio se formaron dos grupos, uno de estudio tratado con oleozón y otro de control tratado con propóleos al 5 %, con 25 pacientes cada uno. Se utilizaron métodos teóricos, empíricos, y se aplicó la prueba de Chi cuadrado con un nivel de significación de p=0.05. Resultados: se demostró la efectividad de la aplicación del oleozón en la muestra seleccionada al presentar una evaluación terapéutica de los pacientes más favorable con respecto a los tratados con propóleos al 5%, alcanzando la mayor cantidad de pacientes curados y con éxito en el tratamiento de la gingivitis crónica, la que fue más presentada por adolescentes masculinos de 13 años, prevaleció en su forma moderada, y la higiene bucal deficiente fue el factor de riesgo de mayor incidencia en su aparición. Conclusiones: la ozonoterapia resultó ser un tratamiento efectivo para la gingivitis crónica en los adolescentes estudiados.

ABSTRACT Introduction: the ozone due to its ample range of properties is useful to treat oral diseases as chronic gingivitis. Objective: to demonstrate the effectiveness of ozone-therapy in the treatment of chronic gingivitis in adolescents at Pedro Borras Astorga Polyclinic, Pinar del Rio municipality, during the period between January and September 2019. Methods: an observational, analytical, longitudinal study of case and control. The sample comprised 50 patients chosen by intentional non-probabilistic method, considering the criteria of inclusion and exclusion. To carry out a better study two groups were included, a study group treated with oil-ozone and a control one treated with propolis at 5 %, with 25 patients each of the group. Theoretical and empirical methods were applied, and the chi-squared test with a significance level of p=0.05. Results: the effectiveness of the application of oil-ozone was demonstrated in the sample chosen when presenting a more favorable therapeutic evaluation of the patients, respect to those treated with propolis at 5 %, reaching the greatest quantity of cured patients and with success in the treatment of chronic gingivitis, which was more frequent in male adolescents (13 years old), its moderate type prevailed, a deficient oral hygiene was the risk factor of highest incidence in its onset. Conclusions: the ozone-therapy resulted in an effective treatment for chronic gingivitis in the studied adolescents.

Ozonoterapia como tratamiento coadyuvante en la úlcera corneal grave bacteriana / Ozone therapy as adjunctive treatment in severe bacterial corneal ulcer / Ozonoterapia como tratamento adjuvante em úlcera bacteriana da córnea grave

Introducción: La evolución espontánea o los casos mal tratados de la úlcera corneal conllevan el riesgo de extensión de la infección, con severa afectación visual e integridad estructural del ojo. Objetivo: Describir las características clínico-epidemiológicas de pacientes con úlcera corneal grave bacteriana tratada con ozonoterapia local coadyuvante al tratamiento protocolizado. Método: Se realizó un estudio observacional, descriptivo y transversal con 48 pacientes ingresados en el servicio de Oftalmología del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso", de Santiago de Cuba, en el periodo de enero de 2017 a diciembre de 2019. Las variables del estudio fueron: edad, sexo, factores predisponentes, microorganismos, signos de mejoría clínica, resultados al tratamiento y complicaciones. Para la validación estadística se utilizó prueba Chi-cuadrado. Resultados: La edad promedio de los pacientes fue de 54,1 años, el 62,5 % eran hombres. Predominó el trauma ocular (63,3 %) en el sexo masculino y enfermedades oculares (44,4 %) en el femenino. La mejoría de los signos fue más representativa a los 14 días. Se logró resultados satisfactorios en el 100 % de los pacientes con microorganismos grampositivos. El 10,4 % presentó perforación corneal. Conclusiones: La ozonoterapia es una terapia válida como tratamiento en la úlcera corneal grave de etiología bacteriana y responde a la búsqueda de alternativas para pacientes con resistencia a los tratamientos antibacterianos que se ofertan en el cuadro básico de salud.

ABSTRACT Introduction: Spontaneous evolution or poorly treated cases of corneal ulcer carry the risk of extension of the infection, with severe visual impairment and damage to the structural integrity of the eye. Objective: To describe the clinical-epidemiological characteristics of patients with severe bacterial corneal ulcer treated with local ozone therapy as an adjunct to the standard protocol treatment. Method: An observational, descriptive and cross-sectional study was carried out on 48 patients admitted to the Ophthalmology service of the Hospital General Docente "Dr. Juan Bruno Zayas Alfonso", from Santiago de Cuba, in the period from January 2017 to December 2019. The study variables were: age, gender, predisposing factors, microorganisms, signs of clinical improvement, treatment results and complications. Chi-square test was used for statistical validation. Results: The average age of the patients was 54.1 years; 62.5% of them were men. Ocular trauma (63.3%) predominated in males, and ocular diseases (44.4%) in females. The improvement of the signs was more common after 14 days. Satisfactory results were achieved in 100% of patients with gram-positive organisms. 10.4% presented corneal perforation. Conclusions: Ozone therapy is valid as a treatment for severe corneal ulcer of bacterial etiology, and responds to the search for alternatives for patients with resistance to the antibacterial treatments that are offered in the basic health system.

RESUMO Introdução: A evolução espontânea ou casos mal tratados de úlcera de córnea trazem o risco de extensão da infecção, com comprometimento visual grave e integridade estrutural do olho. Objetivo: Descrever as características clínico-epidemiológicas de pacientes com úlcera bacteriana de córnea grave tratados com ozonioterapia local como coadjuvante ao tratamento protocolizado. Método: Foi realizado um estudo observacional, descritivo e transversal com 48 pacientes internados no serviço de Oftalmologia do Hospital General Docente "Dr. Juan Bruno Zayas Alfonso", de Santiago de Cuba, no período de janeiro de 2017 a dezembro de 2019. As variáveis do estudo foram: idade, sexo, fatores predisponentes, microrganismos, sinais de melhora clínica, resultados do tratamento e complicações. O teste do qui-quadrado foi usado para validação estatística. Resultados: A idade média dos pacientes foi de 54,1 anos, 62,5% eram homens. O trauma ocular (63,3%) predominou no sexo masculino e as doenças oculares (44,4%) no feminino. A melhoria da sinalização foi mais representativa aos 14 dias. Resultados satisfatórios foram alcançados em 100% dos pacientes com organismos gram-positivos. 10,4% apresentaram perfuração corneana. Conclusões: A ozonioterapia é uma terapia válida como tratamento para úlcera de córnea grave de etiologia bacteriana e responde à busca de alternativas para pacientes com resistência aos tratamentos antibacterianos que são oferecidos no quadro básico de saúde.

Caracterización clínico-terapéutica de pacientes diagnosticados con Osteonecrosis en los maxilares relacionada con medicación / Clinical and therapeutic characterization of patients diagnosed with medication-related osteonecrosis of the jaws

Introducción: La osteonecrosis en los maxilares por medicación es una afección asociada al tratamiento con bifosfonatos, antireabsortivos y antiangiogénicos. Objetivo: Caracterizar clínica y terapéuticamente los pacientes diagnosticados de Osteonecrosis en los Maxilares relacionada con medicación. Material y Método: Se realizó una serie de casos de 19 pacientes, la totalidad de los diagnosticados con la entidad en el Servicio de Cirugía Maxilofacial. Facultad de Estomatología Raúl González Sánchez, enero 2018-enero 2019. Se identificó severidad, factores de riesgo y se estandarizó tratamiento que incluyó la curación con aceite ozonizado y la aplicación de láser infrarrojo. Se evaluó el tratamiento a los 90 días. Se operacionalizaron las variables: sexo, tipo de medicación, vía y tiempo de administración, localización y evaluación al tratamiento. Resultados: La edad promedio de los pacientes fue 69±8,5 años, un 52,63 por ciento fueron masculinos, el zolendronato fue el agente mas asociado en el 78,95 por ciento de los casos, la enfermedad periodontal fue el factor local preponderante (57,89 por ciento), la localización mandibular postero lateral y el estadio evolutivo 2 predominaron en el 63,16 por ciento y 52,63 por ciento de las lesiones. El 78,94 por ciento de los casos presentó evolución satisfactoria a los 90 días. Conclusiones: La medicación con bifosfosfonatos parenterales predominantemente con el zolendronato, fue la causa principal de las osteonecrosis, las cuales prevalecieron en el sector postero lateral de mandíbula y con el estadio 2. La variante de tratamiento de curación con aceite ozonizado e irradiación con láser fue la más implementada. Los valores de lesiones resueltas y mejoradas a los 90 días fueron satisfactorios(AU)

Introduction: Medication-related osteonecrosis of the jaws is an affection associated with the treatment with bisphosphonates, antiresorptive agents or antiangiogenic medications. Objective: To perform a clinical and therapeutic characterization of patients with the diagnosis of medication-related osteonecrosis of the jaws. Material and Method: A case series of a total of 19 patients with the diagnosis of medication-related osteonecrosis of the jaws was carried out in the Department of Dental and Maxillofacial Surgery of ¨Raúl González Sánchez¨ Dental School of Havana from January 2018 to January 2019. The severity and risk factors were identified and the treatment including the healing with ozone oil and the application of infrared laser was standardized. The patients were evaluated in the 90 days after treatment. The operationalization of variables included: sex, type of medications, ways and time of administration, localization, and evaluation of treatment. Results: The average age of patients was 69±8,5 years and 52,63 percent of them were male. Zolendronate was the most associated agent in 78,95 percent of cases. Periodontal disease was the most identified local factor (57, 89 percent). The posterolateral area of the mandible and stage 2 disease evolution predominated in 63,16 percent and 52, 63 percent of lesions, respectively. Also 78, 94 percent of cases had a satisfactory evolution in the 90 days after treatment. Conclusions: The administration of intravenous bisphosphonates, particularly Zolendronate, was the main cause of osteonecrosis. These lesions were mainly located in the posterior lateral area of the mandible and presented stage 2 disease evolution. Healing with ozone oil and application of infrared laser was the most implemented alternative treatment. The values of resolved and improved lesions were satisfactory in the 90 days after treatment(AU)

Potential of Ozone Therapy for Post-stroke Pneumonia (review) / 中国康复理论与实践

Pneumonia is the most common type of post-stroke infection, with an incidence of up to 57%, and is independently associated with poor outcome after stroke. Ozone is a harmless therapy working for anti-inflammatory, anti-oxidative stress and improving oxygenation through various molecular ways, which may be a potential therapy for post-stroke pneumonia.

Ozonized solutions favor the repair of experimentally induced skin wounds in rats / Soluções ozonizadas favorecem o reparo de feridas cutâneas experimentalmente induzidas em ratos

This study aimed to evaluate and compare the effects of ozonized solutions on tissue wound repair in rats. Treatments consisted of ozonized water (GA), 0.9% sodium chloride (GCL), ozonized oil (GO), and 0.2% allantoin cream (GAL). The morphometric evaluation showed that wounds of the GA group presented a higher degree of retraction (p<0.05) at three and eight days of treatment (37.96 and 84.81%, respectively). Picrosirius red staining showed that groups GA and GO presented higher deposition (p<0.05) of type I collagen at 15 and 22 days of treatment, respectively. The neovascularization was higher in wounds of group GO on days 3, 8, and 15 (p<0.05), with higher VEGF immunostaining. (p<0.05). Thus, ozonized water enhances wound retraction and assists in the maturation and remodeling phase, while ozonized oil promotes higher neovascularization during tissue repair and higher deposition of type I collagen from the third week of treatment.(AU)

O objetivo deste estudo foi avaliar e comparar os efeitos de soluções ozonizadas sobre o reparo tecidual de feridas em ratos. Foram realizados os tratamentos: água ozonizada (GA), cloreto de sódio 0,9% (GCL), óleo ozonizado (GO) e creme de alantoína 0,2% (GAL). À avaliação morfométrica, as feridas do grupo GA apresentaram maior grau de retração (p<0,05) aos três e oito dias de tratamento (37,96% e 84,81%, respectivamente). A coloração de picrosirius red mostrou que os grupos GA e GO apresentaram maior deposição (p<0,05) de colágeno do tipo I aos 15 e aos 22 dias de tratamento, respectivamente. Já a variável neovascularização foi maior (p<0,05) nas feridas do grupo GO nos dias três, oito e 15, o que fora ratificado à imunoistoquímica, com maior imunomarcação de VEGF nas feridas do grupo GO (p<0,05). Conclui-se que a água ozonizada potencializa a retração da ferida e auxilia na fase de maturação e remodelamento, enquanto o óleo ozonizado promove maior neovascularização durante o reparo tecidual e maior deposição de colágeno do tipo I a partir da terceira semana de tratamento.(AU)

Aplicabilidade da ozonioterapia na odontologia: uma revisão de literatura / Applicability of ozone therapy in dentistry: a literature review

A Ozonioterapia, método que utiliza a mistura gasosa de ozônio e oxigênio, é uma das Práticas Integrativas aprovadas pelo Ministério da Saúde. Atualmente é utilizada na Odontologia devido, principalmente, às suas características estruturais que permitem vastas aplicações. Essa Prática tem como principal objetivo os fins terapêuticos, por meio de propostas cada vez mais efetivas, que corroboram para técnicas e métodos capazes de propiciar tratamentos complementares a fim de curar e prevenir patologias inerentes à cavidade oral, contribuindo para a potencialização de resultados das técnicas já existentes. Em virtude da busca por técnicas complementares, a Ozonioterapia ganhou destaque e tem se mostrado efetiva e segura em diversas práticas odontológicas. O presente trabalho tem por objetivo, por meio de uma revisão de literatura, ressaltar as aplicabilidades do Ozônio (O3) na área odontológica, explicitando meios de utilização e suas respectivas ações, bem como, as contraindicações frente às ocorrências que acometem a cavidade oral.

Ozone therapy, a method that uses a gaseous mixture of ozone and oxygen, is one of the Integrative Practices approved by the Brazilian Ministry of Health. It is currently used in dentistry mainly due to its structural characteristics that allow a wide range of applications. This Practice focuses on therapeutic purposes through increasingly effective proposals that corroborate techniques and methods capable of providing complementary treatments in order to cure and prevent pathologies inherent to the oral cavity, contributing to the potentiation of results from existing techniques. Due to the search for complementary techniques, ozone therapy has gained prominence and has proven to be both effective and safe in several dental practices. This work aims at highlighting the applicability of Ozone (O3) in the dental area through a literature review, explaining means of use and their respective actions, as well as the contraindications to occurrences that affect the oral cavity.

Ozonoterapia como adyuvante en el tratamiento periodontal no quirúrgico y quirúrgico / Ozonoterapia as adjuvant in the non-surgical and surgical periodontal treatment

Introducción: El ozono (O3) presenta múltiples acciones biológicas, entre ellas su efecto antimicrobiano, lo que ha sido beneficioso en odontología, siendo la presentación acuosa la más utilizada (20 µg/ mL), la cual presenta efectos similares a la clorhexidina. Reporte de caso: Paciente masculino de 76 años de edad, diagnosticado con periodontitis crónica moderada localizada, el cual fue tratado mediante ozonoterapia acuosa durante la fase inicial periodontal y la fase quirúrgica en colgajo por debridación. 12 semanas posteriores al acto quirúrgico se obtuvo la eliminación de las bolsas periodontales, encontrándose un surco de 3 y 2 mm y un buen control de placa dentobacteriana. Conclusión: No existen reportes acerca del uso de ozonoterapia acuosa durante un colgajo por debridación. El éxito del tratamiento periodontal consiste en la eliminación del factor causal así como en establecer y mantener un control de placa dentobacteriana adecuado (AU)

Introduction: Ozone (O3) has multiple biological actions, including its antimicrobial effect, which has been beneficial in dentistry, the aqueous presentation being the most used (20 µg/mL), which has similar effects to chlorhexidine. Case report: Male patient of 76 years of age, diagnosed with localized moderate chronic periodontitis, which was treated by aqueous ozone therapy during the initial periodontal phase and surgical phase in debridement flap. Twelve weeks after surgery, the periodontal pockets were eliminated, finding a 3 and 2 mm groove and good control of dentobacterial plaque. Conclusion: There are no reports about the use of aqueous ozone therapy during a debridement flap. The success of the periodontal treatment consists in the elimination of the causal factor, as well as establishing and maintaining an adequate control of plaque (AU)

Ozonoterapia sistémica en pacientes diabéticos insulinodependientes con dolor neuropático / Systemic ozone therapy in insulin-dependent diabetic patients with neuropathic pain

Introducción: Con frecuencia, los pacientes diabéticos presentan dolor neuropático como complicación de su enfermedad. Objetivo: Identificar las ventajas de la ozonoterapia sistémica en pacientes diabéticos insulinodependientes con dolor neuropático. Métodos: Se realizó un estudio descriptivo en diabéticos insulinodependientes con dolor neuropático que acudieron a la Clínica del Dolor del Hospital Clínico Quirúrgico Hermanos Ameijeiras entre febrero de 2014 hasta enero de 2019. A todos se les cuantificó el dolor, la presencia de parestesias, la fuerza muscular, el reflejo aquiliano y la hemoglobina glicosilada. Se administraron 15 sesiones de ozono vía rectal y 6 de autohemoterapia mayor. Se compararon los resultados de la primera sesión y en la última (8 semanas de tratamiento). Resultados: El 45,3 por ciento tenían 60 años o más, 59 por ciento eran del sexo femenino y 89,3 por ciento tenían 15 o más años de evolución de la diabetes. En la primera consulta la intensidad del dolor en 100 por ciento osciló entre 7 y 10 de la escala numérica verbal y todos presentaron parestesias. En 59,3 por ciento existió disminución de la fuerza muscular, 62 por ciento presentó reflejo aquiliano disminuido y 88 por ciento hemoglobina glicosilada mayor o igual a 12 por ciento. Estos síntomas mejoraron a las ocho semanas. Conclusiones: Las probadas propiedades analgésicas y antiinflamatorias del ozono lo convierten en la actualidad en una herramienta terapéuticas de las más eficientes para el control del dolor crónico en pacientes diabéticos insulinodependientes(AU)

Introduction: Frequently, diabetic patients present neuropathic pain as a complication of their disease. Objective: To identify the advantages of systemic ozone therapy for insulin-dependent diabetic patients with neuropathic pain. Methods: A descriptive study was carried out with insulin-dependent diabetic patients with neuropathic pain who attended the Pain Clinic of Hermanos Ameijeiras Clinical-Surgical Hospital between February 2014 until January 2019. All of them were quantified pain, the presence of paresthesias, muscle strength, ankle jerk reflex, and glycosylated hemoglobin. The patients received fifteen sessions of rectal ozone and six sessions of major self-hemotherapy. We compared the outcomes after the first session and after the last one (eight weeks). Results: 45.3 percent were 60 years or older, 59 percent were female, and 89.3 percent had a natural history of diabetes of 15 years or more. In the first hospital visit, the intensity of 100 percent pain ranged between 7 and 10 according to the verbal numeric scale, and all presented paresthesias. In 59.3 percent, there was a decrease in muscle strength, 62 percent had decreased ankle jerk reflex, and 88 percent had glycosylated hemoglobin higher than or equal to 12 percent. These symptoms improved at week eight. Conclusions: The proven analgesic and anti-inflammatory properties of ozone make it currently a therapeutic tool among the most efficient for controlling chronic pain in insulin-dependent diabetic patients(AU)

Comparison of the effectiveness of platelet rich plasma and ozone therapy in plantar fasciitis treatment

Background: Plantar fasciitis (PF) is one of the most common foot problems in adults. Conservative treatments are proportionally 90-95% successful. In this study, author aimed to compare the effectiveness of ozone therapy (OT) treatment of platelet rich plasma (PRP) injections in PF patients.Methods: In the study, which was made prospectively, patients were randomly divided into two groups. In the first group (n=20), patients were injected with PRP in 3 sessions at a one week intervals, and in the second group (n=22) OT was injected in the same way. Each patient was evaluated with visual pain score before as well as 1 month after treatment in terms of pain, whereas the foot function index (FFI) was evaluated with the score in terms of functionality.Results: In both groups, the 1st month VAS score and FFI score showed significant decrease (p<0.05) after treatment compared to before treatment. The decrease in VAS score and FFI score after treatment in the PRP group was significantly higher than the OT group (p˂0.05).Conclusions: As a result of this study, authors found that both PRP and OT were beneficial in terms of pain and functional level in the treatment of PF, but in patients who underwent PRP, authors found that there was more statistical improvement in terms of both parameters than patients who received OT. In light of the absence of a previous publication comparing these two treatment options in PF treatment, this study contributes to the literature.

Ozonoterapia rectal en pacientes con osteoartritis / Rectal ozone therapy in patients with osteoarthritis

Introducción: La osteoartritis es una de las principales causas de dolor y discapacidad en el mundo. La ozonoterapia actúa como medio terapéutico, mejora la calidad del cartílago articular, disminuye la inflamación producida y presenta propiedades moduladoras del sistema inmune. Objetivo: Evaluar los resultados de la ozonoterapia rectal en pacientes con osteoartritis. Método: Se realizó un estudio descriptivo prospectivo, en el Servicio de Reumatología del Hospital Clínico Quirúrgico Lucía Iñiguez Landín, de Holguín en el período comprendido de julio de 2017 a febrero de 2019. La población del estudio quedó conformada por 101 pacientes. La muestra fue de 60 pacientes, seleccionada según un muestreo aleatorio simple. Resultados: La articulación más afectada fue la rodilla en 100 por ciento de los pacientes estudiados. El mayor número de pacientes presentaba discapacidad física moderada (53,3 por ciento) al inicio del tratamiento y a los 3 meses predominó la discapacidad ligera (26,6 (por ciento). Se logra reducir el uso de analgésicos de forma ocasional al concluir tratamiento. Conclusiones: En los pacientes con discapacidad funcional por osteoartritis tratados con ozonoterapia transrectal el efecto terapéutico fue muy bueno(AU)

Introduction: Osteoarthritis is one of the main causes of pain and disability worldwide. Ozone therapy acts as a therapeutic means, improves the quality of articular cartilage, reduces the resulting inflammation and has modulating properties of the immune system. Objective: To evaluate the results of rectal ozone therapy in patients with osteoarthritis. Method: A prospective descriptive study was carried out in the Rheumatology Service of Lucía Iñiguez Landín Surgical Clinical Hospital, in Holguín from July 2017 to February 2019. One hundred one patients consisted the study population. Sixty patients formed the sample, selected according to a simple random sampling. Results: The most affected joint was the knee in 100 percent of the studied patients. The highest number of patients had moderate physical disability (53.3 percent) at the start of treatment and at 3 months later, mild disability predominated (26.6 percent). It was possible to reduce the use of pain relievers occasionally at the end of treatment. Conclusions: The therapeutic effect of transrectal ozone therapy was very good in patients with functional disability due to osteoarthritis(AU)

Effects of transrectal medicinal ozone in horses - clinical and laboratory aspects / Efeitos do ozônio medicinal transretal em cavalos - aspectos clínicos e laboratoriais

Ozone (O3) therapy has been used for medical procedures for centuries; however, there are no extensive studies on its utilization in horses. This study aimed to evaluate the application of transrectal O3 on horses by physical and laboratorial evaluation, and production of reactive oxygen species (ROS). Sixteen healthy horses were separated in two groups: a control group (CG) and a group treated with O3 (TG). The TG animals received 1L of an oxygen and O3 mixture transrectally. The initial dose was 10µg/ml for the first two applications, 15µg/ml for the following two applications, and 20µg/ml for the next six applications. The CG animals received 1L of oxygen transrectally. In TG animals no variations in the physical examination were detected; furthermore, TG animals did not exhibit changes in biochemical evaluation results, fibrinogen concentrations, or ROS production. TG animals had increased red blood cell counts, hemoglobin concentrations, and packet cell volume values in comparison to the baseline and CG values. We could infer that O3 affected the red blood cell counts and improved rhetological properties of the blood. The transrectal application of O3 in horses is safe and can indirectly improve the oxygenation and metabolism of tissues.(AU)

A utilização medicinal do ozônio (O3) é secular, contudo não existem estudos expressivos de sua utilização em equinos. O objetivo deste estudo foi avaliar o efeito da aplicação transretal de O3 em equinos por meio da avaliação física, laboratorial, e produção de espécies reativas de oxigênio (EROs). Dezesseis equinos hígidos foram separados em dois grupos: grupo controle (GC) e grupo tratado com O3 (GT). O GT recebeu por via retal 1L da mistura de oxigênio e ozônio, sendo a dose inicial de 10µg/ml por duas aplicações, 15µg/ml por mais duas aplicações e 20µg/ml por seis aplicações. O GC recebeu 1L de oxigênio via transretal. No GT não foram observadas alterações no exame físico, bem como não foram observadas alterações na avaliação bioquímica, concentração de fibrinogênio e produção de EROs. O GT apresentou aumento no número de hemácias, na concentração de hemoglobina, e nos valores de hematócrito em relação aos valores basais e GC. Podemos inferir que o O3 alterou os valores de eritrócitos e melhorou as propriedades reológicas do sangue. Conclui-se que a aplicação transretal de 03 em equinos é segura e pode melhorar indiretamente a oxigenação e metabolismo dos tecidos.(AU)

Uso de ozonoterapia en las pacientes con enfermedad inflamatoria pélvica aguda Etapa III / Ozone Therapy in Patients with Acute Pelvic Inflammatory Disease Stage III

Introducción: La ozonoterapia es un proceder terapéutico que ha resultado ser eficaz en el tratamiento de diferentes enfermedades. Tiene efectos como bactericida, virucida, fungicida y parasiticida, por lo que la enfermedad inflamatoria pélvica, es tributaria de este tratamiento. Objetivo: Determinar evolución de pacientes con absceso tubo ovárico, tratadas con ozonoterapia asociada al tratamiento convencional. Métodos: Estudio observacional, longitudinal, prospectivo. Se determinó evolución de pacientes con diagnóstico de absceso tubo ovárico, tratadas con ozonoterapia asociada al tratamiento convencional en el período comprendido entre marzo 2014 y marzo 2018. El universo fue constituido por las pacientes ingresadas con la entidad. La selección de la muestra fue aleatoria, y se conformó por 63 casos en dos grupos de estudio, Grupo I (se administró ozonoterapia), y Grupo II (no se administró). Resultados: A los 7 días de tratamiento con ozono, la eritrosedimentación persistía elevada por encima de 3 cifras en 41,9 por ciento de las pacientes, y 35,4 por ciento presentaba dolor pélvico en el grupo I; en contraste con el grupo II que mantenía la eritrosedimentación elevada en 75 por ciento de ellas, y 53,1 por ciento tenía dolor. Al mes se constata disminución de las dimensiones de la tumoración en ultrasonido en 61,2 por ciento de las pacientes del grupo I, y 34,3 por ciento del grupo II. Conclusiones: Las pacientes tratadas con ozonoterapia, tuvieron reducción de la masa pélvica y remisión más rápida de los síntomas clínicos y los complementarios, que las que no recibieron esta alternativa de tratamiento(AU)

Introduction: Ozone therapy is a therapeutic procedure that has proven to be effective in the treatment of different diseases. It has effects such as bactericidal, virucidal, fungicidal and parasiticidal, so pelvic inflammatory disease is tributary to this treatment. Objective: To determine the evolution of patients with ovarian tube abscess, treated with ozone therapy associated with conventional treatment. Methods: Observational, longitudinal, prospective study. Evolution of patients diagnosed with ovarian tube abscess was determined, who were treated with ozone therapy associated with conventional treatment from March 2014 to March 2018. The universe was constituted by patients admitted with the institution. The sample selection was randomized, and 63 cases in two study groups made up the sample. Group I (ozone therapy was administered), and Group II (no ozone therapy was administered). Results: At 7 days of ozone treatment, erythrosedimentation remained high above 3 figures in 41.9 percent of the patients, and 35.4 percent had pelvic pain in group I; in contrast to group II that maintained erythrosedimentation elevated in 75 percent, and 53.1 percent had pain. A month after the treatment, a decrease in the size of the ultrasound tumor was observed in 61.2 percent of the patients in group I, and 34.3 percen t in group II. Conclusions: Patients treated with ozone therapy had pelvic mass reduction and faster remission of clinical symptoms and complementaries, than those who did not receive this treatment alternative(AU)

Aplicación del ozono interescalénico en la radiculopatía cervical por hernia discal / Application of intercalenic ozone in cervical radiculopathy due to herniated disc

Introducción: el ozono es un gas médico descrito desde el siglo XIX que ha tenido su evolución hasta a la fecha en cuanto a sus aplicaciones y su utilidad en diversas enfermedades por su actuación a nivel molecular y en disímiles enfermedades asociadas a procesos dolorosos de origen inflamatorio como los presentes en las hernia discales de la columna vertebral. Método: estudio retrospectivo con 20 pacientes atendidos en la consulta externa de Neurocirugía del Hospital Miguel Enríquez desde de Diciembre 2016 hasta Abril 2017 con el diagnostico de una radiculopatía cervical por hernia discal. Se le aplicó 10 ML de ozono con una concentración 22 mg/litro tres veces en la semana durante 10 semanas solamente se utilizó este tipo de terapia; obteniendo mejoría en 15 pacientes. Resultados: predominando los mayores de 51 años para un 50 por ciento, en nuestra serie predominó el sexo femenino para un 80 por ciento. En cuanto al cuadro clínico prevaleció la disminución de la fuerza muscular para un 60 por ciento en 12 pacientes, seguidos del dolor cervical y el interescapular para un 75 por ciento y 55 por ciento respectivamente. Se halló mejoría en 15 pacientes para un 75 por ciento y en los otros 5, en tres pacientes no continuaron el tratamiento y en dos no se obtuvo mejoría. Conclusiones: tenemos otra alternativa en la aplicación del ozono por el espacio interescalénico como tratamiento analgésicos y antiinflamatorio en las radiculopatía por hernia discales cervicales(AU)

Introduction: Ozone is a medical gas described since the nineteenth century that has had its evolution up to date in terms of its applications and its usefulness in various diseases for its performance at the molecular level and dissimilar diseases associated with painful processes of inflammatory origin such as those present in herniated discs of the spine. Method: Retrospective study with 20 patients assisted in the outpatient consultation of the Miguel Enríquez Hospital from December 2016 to April 2017 with the diagnosis of a cervical radiculopathy by herniated disc. 10 ML of ozone applied with a concentration of 22 mg/liter three times in the week for 10 weeks only this type of therapy used getting improvement in 15 patients. Results: predominating the older than 51 years for 50 percent, in our series predominated the female sex for 80 percent .As for the clinical picture, decreased muscle strength was prevailed for 60 percent in 12 patients, followed by cervical pain and interescapular for 75 percent and 55 percent respectively. We found improvement in 15 patients for 75 percent and in the other 5, in 3 patients did not continue the treatment and in two, no improvement obtained. Conclusions: We have another alternative in the application of ozone by the intercalenic space as analgesic and anti-inflammatory treatment in cervical herniated discus radiculopathy(AU)

Evolución de las úlceras de pie diabético con el tratamiento mixto de Heberprot-P® y ozonoterapia / Evolution of diabetic foot ulcers with the mixed treatment of Heberprot-P® and ozone therapy

Introducción: El Heberprot-P® es un medicamento novedoso y único, prescrito para los pacientes con úlcera del pie diabético. El factor de crecimiento humano recombinante que contiene este fármaco induce el crecimiento de tejido de granulación útil. La ozonoterapia tiene propiedades como oxigenante, antioxidante, inmunomodulador, regenerador, antiinflamatorio y germicida y se utiliza para la desinfección de heridas desde la Primera Guerra Mundial. Objetivo: Determinar la evolución de las úlceras del pie diabético con el tratamiento mixto de Heberprot-P® y ozonoterapia. Métodos: Se realizó un estudio retrospectivo y descriptivo en todos los pacientes ingresados en el Instituto Nacional de Angiología y Cirugía Vascular con el diagnóstico de diabetes mellitus y úlcera de pie diabético que recibieron tratamiento mixto de Heberprot-P® y ozonoterapia. El período de estudio osciló de enero de 2016 hasta enero de 2017. Las variables estudiadas fueron: sexo, edad, tipo de diabetes, estadía hospitalaria, necesidad de ser reintervenido, tiempo de granulación y respuesta al tratamiento. Resultados: Se encontró que los pacientes tratados con el Heberprot-p® y ozonoterapia tuvieron una buena respuesta al tratamiento (60,5 por ciento), un tiempo de granulación entre 2 y 4 semanas (55,6 por ciento) con predominio de la estadía hospitalaria de 11 a 21 días. Conclusiones: Los pacientes con el tratamiento mixto de Heberprot-P® y ozonoterapia tienen una respuesta muy favorable(AU)

Introduction: Heberprot-P® is a novel and unique medication, prescribed for patients with diabetic foot ulcer. It is based on recombinant human growth factor that induces the growth of useful granulation tissue. The properties as oxygenating, antioxidant, immunomodulator, regenerator, anti-inflammatory and germicide of ozone therapy are used for the disinfection of wounds since the First World War. Objective: To determine the evolution of diabetic foot ulcers with the mixed treatment of Heberprot-P® and ozone therapy. Methods: A retrospective and descriptive study was conducted in all patients admitted to the National Institute of Angiology and Vascular Surgery (INACV) with the diagnosis of Diabetes Mellitus and diabetic foot ulcer who received mixed treatment of Heberprot-P® and ozone therapy. The study period ranged from January 2016 to January 2017. The studied variables were: sex, age, type of diabetes, hospital stay, need to be reoperated, granulation time and response to the treatment. Results: It was found that the highest percentage of patients who used the mixed treatment of Heberprot-P® and ozone therapy had a good response to treatment (60.5 percent) and a granulation time between 2 and 4 weeks (55.6 percent); and a hospital stay from 11 to 21 days. Conclusions: Patients with the mixed treatment of Heberprot-P® and ozone therapy have a very favorable response(AU)