RESUMEN
Objective To investigate the protective effect of Xinan granule on viral myocarditis in mice. Methods Viral myocarditis model was made by intraperitoneal inoculation with Coxsackie virus B3 in BALB/C mice. Mice were randomly devided into six groups:the normal control group, the model control group, the Xinan granule10、20、40 g/(kg?d) groups and the Binduzuo 0.1 g/(kg?d) group.After CVB3 infection 2 h, one set of mice were given drugs for 7 d.Blood and heart samples were obtained on the 8th day after CVB3 infection.The myocardial histopathologic changes were observed. The serum cardiac enzyme (LDH) were measured.The others were given drugs for 2 d before CVB3 infection, and for 7ds after CVB3 infection. The survival time were recorded for 20 ds. Results The myocardial histopathologic damage, LDH, cardiac index, punctate hemorrhage on heart surface in Xinan group reduced more significantly than that of the model control group. The survival time in Xinan group were longer than that of the model control group. Conclusion Xinan granule may have the preventional and therapeutic effect on viral myocarditis in mice.
RESUMEN
A retrospective study on 218 patients indicated the ultrasound Doppler to diagnose the vascular pathology in the pelvic limb has shown that the image of ultrasound found the artherosclerosis in the major arteries, which frequently occurred in the patients with the blood supply insufficiency for limb during movement. The lesion of vasculitis and arterial thrombosis and embolism only located in the minor arteries and not found by ultrasound. When finding the lesion of artherosclerosis included thrombolism in the medium or major arteries, the patients should be indicated the angiography to identify and evaluate generally for next indications