RESUMEN
Drug-induced liver injury (DILI) is not only a hot topic in the field of liver diseases around the world, but also a major concern in the field of global drug safety at present. Due to a lack of specific indices, the misdiagnosis rate of DILI is high and there may be important issues in drug safety. DILI caused by Chinese herbal medicine has complex etiologies, with difficulties in clinical diagnosis, prevention, and control. Therefore, clinicians should cooperate with pharmaceutical experts to establish the strategies and methods for objective identification of DILI, clarify the causal relationship between drug and liver injury in order to realize the precise diagnosis of DILI. The etiology and pathogenesis about susceptible population, risk substance of drugs and rational usage of DILI should be clarified to manage DILI. Also, the research on liver injury induced by Chinese herbal medicine should be further emphasized and strengthened to guarantee the drug safety in clinical practice, and to promote the healthy development of traditional Chinese medicine.
RESUMEN
Drug-induced liver injury (DILI) is not only a hot topic in the field of liver diseases around the world, but also a major concern in the field of global drug safety at present. Due to a lack of specific indices, the misdiagnosis rate of DILI is high and there may be important issues in drug safety. DILI caused by Chinese herbal medicine has complex etiologies, with difficulties in clinical diagnosis, prevention, and control. Therefore, clinicians should cooperate with pharmaceutical experts to establish the strategies and methods for objective identification of DILI, clarify the causal relationship between drug and liver injury in order to realize the precise diagnosis of DILI. The etiology and pathogenesis about susceptible population, risk substance of drugs and rational usage of DILI should be clarified to manage DILI. Also, the research on liver injury induced by Chinese herbal medicine should be further emphasized and strengthened to guarantee the drug safety in clinical practice, and to promote the healthy development of traditional Chinese medicine.