Cerebral Blood Flow(CBF) Study on Moyamoya Disease

The author analyzed the r-CBF data of 19 patients who admitted to the Kyung Hee University Medical Center under the diagnosis of definite "Moyamoya" disease from 1983 to 1992. Seven of them were followed-up from 1 to 18 months. The results were as fllow : 1) In moyamoya disease patients, the mean hemispheric r-CBF has a tendency to be lower than that of healthy persons. 2) In moyamoya disease patients, the ipsilateral r-CBF also shows a tendency to be lower than that of contralateral side. 3) The 133Xe-inhalation method is one of useful methods to evaluate CBF in Moyamoya disease, especially for follow-up. 4) The results of follow-up study for Moyamoya disease by 133Xe-inhalation method corelate very well with the change in clinical status of the patients. 5) In Moyamoya disease patients, the follow-up by means of 133Xe-inhalation method is one of useful methods to select a good candidate for surgical treatment such as STA-MAC anastomosis.

Correlation of Evoked Potentials and Regional Cerebral Blood Flow in SAH Patients with Vasospasm

With 4 channel Nicolet-CA 1000 clinical averager and 133 Xenon inhalation method, somatosensory evoked potentials (SSEP), brainstem auditory evoked potentials (BAEP) and regional cerebral blood flow (r-CBF) were studied in 30 patients with ruptured cerebral aneurysms. 8 out of 30 patients had abnormal SSEP, 11 out of 30 patients had abnormal BAEP and 4 out of 14 patients had decreased r-CBF. The SSEP was abnormal in 6 out of 10 patients with severe vasospasm but in only 2 out of 20 patients without vasospasm or with mild and moderate spasm. The BAEP was abnormal in 5 out of 10 patients with severe vasospasm but 6 out of 20 patients without spasm or with mild and moderate spasm. Regional CBF was decreased in 3 out of 4 patients with severe vasospasm but only 1 out of 10 patients without spasm or with mild and moderate spasm. Abnormal SSEP, BAEP & decreased r-CBF in patients with severe vasospasm indicated a poor prognosis. We got the results as follows ; 1) Abnormal SSEP, BAEP and decreased r-CBF are correlated with severity of vasospasm in SAH patients. 2) Abnormal SSEP and BAEP correlated with the clinical status. 3) Brain stem transmission time (BTT) is less sensitive than central conduction time (CCT) as indicator of vasospasm.