Reconhecimento de emoções pela voz e expressão facial por estudantes de medicina / Recognition of emotions by voice and facial expression by medical students

RESUMO Objetivo avaliar a capacidade de estudantes de medicina para reconhecer emoções pela voz e expressão facial, por meio de avaliações de percepção emocional da entonação vocal e das expressões faciais. Métodos estudo com delineamento transversal observacional. Para avaliação do reconhecimento de emoções pelas expressões faciais, utilizou-se um teste composto por 20 vídeos de microexpressões faciais e, para avaliação do reconhecimento emocional pela voz, utilizou-se o Protocolo de Reconhecimento de Emoções Prosódicas Básicas, baseado no banco de dados de Burkhardt. Para análise estatística, foram utilizados os testes de Friedman, Shapiro-Wilk, teste t de Student ou Mann-Whitney e o coeficiente de correlação de Pearson ou Spearman. Resultados o estudo foi composto por 38 alunos, com média de idade de 20,8 (±2,5). O reconhecimento de emoções pela voz foi significativamente superior, comparado com os resultados do teste de reconhecimento de emoções pelas expressões faciais. Houve correlação positiva entre a idade e a habilidade de reconhecer emoções pelas expressões faciais. O gênero masculino apresentou taxa significativa de acertos, superior ao gênero feminino na habilidade de reconhecer emoções pela expressão facial. As emoções com maior média de acertos pela expressão facial foram surpresa, alegria e desprezo, enquanto, por meio da voz, as emoções foram raiva, medo e tristeza. Conclusão a capacidade de reconhecimento de emoções por estudantes de medicina foi maior na avaliação de percepção emocional por meio da voz.

ABSTRACT Purpose To evaluate the ability of medical students to recognize emotions through voice and facial expression through assessments of emotional perception of vocal intonation and functional expressions. Methods Observational cross-sectional study. To evaluate the recognition of emotions by facial expressions, a test composed of 20 videos of facial microexpressions was used, and to evaluate the emotional recognition by voice, the protocol of prosodic impressions of basic emotions, based on the Burkhardt database, was used. For statistical analysis, the Friedman, Shapiro-Wilk, Student t, Mann-Whitney and Pearson or Spearman correlation coefficient tests were used. Results The study consisted of 38 students, with an average age of 20.8 (±2.5). The recognition of emotions through the voice was significantly superior to the one through facial expressions. There was a positive correlation between age and the ability to recognize emotions through facial expressions. Males had a significantly higher hit rate than females in the ability to recognize emotions through facial expression. The emotions with the highest average success rates through facial expression were surprise, joy and contempt, while, through the voice, the emotions were anger, fear and sadness. Conclusion The ability to recognize emotions by medical students was greater when assessing emotional perception through the voice.

A importância do corpo junto à função de reconhecimento / The importance of the body in the recognition function / La importancia del cuerpo en la función de reconocimiento / L'importance du corps et la fonction de reconnaissance

Resumo O reconhecimento se apresenta como via pela qual o psiquismo poderá se desenvolver e complexificar a partir de seu encontro com o outro e as afetações que este irá suscitar. Da mesma forma, o reconhecimento se apresenta enquanto movimento de afirmação de si por um elemento do meio externo com o qual o indivíduo se relaciona. Nesse contexto, vemo-nos diante de modalidades de interação da personalidade por meio de vias não-verbais, o que confere grande relevância ao corpo em nosso estudo, apresentando-se enquanto palco que torna possível a expressão e reconhecimento de determinados conteúdos psíquicos que de outra forma não poderiam ser postos em cena nas relações.

Abstract Recognition is presented as a way the psyche can develop and complexify from its encounter with the other and the affects this will arouse. Likewise, recognition is presented as a movement of affirming oneself by an element of the external environment the individual relates to. In this context, we are faced with modalities of personality interaction via non-verbal means, giving the body great relevance in our study, which presents itself as a stage that makes it possible to express and recognize certain psychic contents that could not otherwise be brought into play in relationships.

Resumen El reconocimiento se presenta como una vía por la cual la psique puede desarrollarse y complejizarse a partir de su encuentro con el otro y los afectos que este generará. Asimismo, el reconocimiento manifiesta como un movimiento de afirmación por parte de un elemento del entorno externo con el que se relaciona el individuo. En este contexto, nos encontramos ante modalidades de interacción de la personalidad a través de vías no verbales, lo que otorga gran importancia al cuerpo en nuestro estudio, presentándose como una etapa que posibilita la expresión y reconocimiento de ciertos contenidos psíquicos que de otra manera no podrían ser puestos en juego en las relaciones.

Résumé La reconnaissance est présentée comme un moyen par lequel le psychisme peut se développer et se complexifier en fonction de sa rencontre avec l'autre et des affectations que cela va susciter. De même, la reconnaissance est présentée comme un mouvement d'affirmation de soi par un élément de l'environnement extérieur avec lequel l'individu est en relation. Dans ce contexte, nous sommes confrontés à des modalités d'interaction de la personnalité par des voies non verbales, ce qui donne une grande importance au corps dans notre étude, se présentant comme une étape qui rend possible l'expression et la reconnaissance de certains contenus psychiques qui, autrement, ne pourrait pas être joué dans les relations.

Avaliação e Ensino de Emoções com Crianças e Jovens Adultos com Autismo ou Síndrome de Down Mediado pela Família / Assessment and Teaching of Emotions with Children and Young Adults with Autism or Down Syndrome Mediated by Family / Evaluación y Enseñanza de las Emociones con Niños y Jóvenes con Autismo o Síndrome de Down Mediadas por la Familia

Resumo: Este estudo avaliou o reconhecimento (imitação, identidade e identificação) e a nomeação de estímulos emocionais de valência negativa (raiva e tristeza) e positiva (alegria e surpresa) em conjunto com a influência dos tipos de estímulos utilizados (social-feminino, social-masculino, familiar e emoji) em crianças e jovens adultos com autismo ou síndrome de Down, por meio de tarefas aplicadas pela família e mediadas por recursos tecnológicos durante a pandemia de covid-19. Participaram cinco crianças e dois jovens adultos com autismo e uma criança e dois jovens adultos com síndrome de Down. Foram implementadas tarefas de identidade, reconhecimento, nomeação e imitação, com estímulos faciais de função avaliativa (sem consequência diferencial) e de ensino (com consequência diferencial, uso de dicas e critério de aprendizagem), visando a emergência da nomeação emocional por meio do ensino das tarefas de reconhecimento. Os resultados da linha de base identificaram que, para os participantes que apresentaram menor tempo de resposta para o mesmo gênero, a diferença de tempo de resposta foi em média 57,28% menor. Em relação à valência emocional, 50% dos participantes apresentaram diferenças nos acertos, a depender da valência positiva e negativa, sendo que 66,66% apresentaram diferenças para o tempo de resposta a depender da valência emocional. Após o procedimento de ensino, os participantes mostraram maior número de acertos nas tarefas, independentemente do gênero de estímulo e valência emocional, criando ocasião para generalização da aprendizagem de reconhecimento e nomeação de emoções, além de consolidar a viabilidade de estratégias de ensino mediadas por recursos tecnológicos e aplicadas por familiares.

Abstract: This study evaluated the recognition (imitation, identity, and identification) and naming of negative (anger and sadness) and positive (joy and surprise) emotional stimuli alongside the influence of the types of stimuli (social-female, social-male, family, and emoji) in children and young adults with autism and Down syndrome, via tasks applied by the family and mediated by technological resources, during the COVID-19 pandemic. Five children and two young adults with autism and one child and two young adults with Down syndrome participated. Identity, recognition, naming, and imitation tasks were planned and implemented using facial stimuli with evaluative (without differential consequence) and teaching (with differential consequence, tips, and learning criteria) functions, aiming at the emergence of emotional naming from the recognition teaching tasks. The baseline results showed that, for participants who had a shorter response time for the same gender, the response time difference was on average 57.28% lower. Regarding the emotional valence, 50% of the participants showed differences in the correct answers, depending on the positive and negative valence, and 66.66% showed differences in the response time depending on the emotional valence. After the teaching procedure, the participants showed a greater number of correct answers in the tasks, regardless of the stimulus type and emotional valence, creating an opportunity for generalizing learning of emotion recognition and naming, in addition to consolidating the feasibility of teaching strategies mediated by technological resources and applied by family members.

Resumen: Este estudio evaluó el reconocimiento (imitación, identidad e identificación) y la denominación de estímulos emocionales negativos (enfado y tristeza) y positivos (alegría y sorpresa) y la influencia de los tipos de estímulos utilizados (social-femenino, social-masculino, familiar y emoji ) de niños y jóvenes con autismo o síndrome de Down, a través de tareas aplicadas por la familia, mediadas por recursos tecnológicos durante la pandemia de la covid-19. Participaron cinco niños y dos adultos jóvenes con autismo, y un niño y dos adultos jóvenes con síndrome de Down. Se planificaron e implementaron tareas de identidad, reconocimiento, nombramiento e imitación con estímulos faciales con función evaluativa (sin consecuencia diferencial) y enseñanza (con consecuencia diferencial, uso de ayudas y criterios de aprendizaje), buscando la emergencia del nombramiento emocional después de la enseñanza de tareas de reconocimiento. Los resultados de la línea de base identificaron que para los participantes que tenían un tiempo de respuesta más corto para el mismo género, la diferencia en el tiempo de respuesta fue un 57,28% menor. En cuanto a la valencia emocional, el 50% de los participantes mostraron diferencias en las respuestas correctas, en función de la valencia positiva y negativa, y el 66,66% tuvieron diferencias en el tiempo de respuesta, en función de la valencia emocional. Después del procedimiento de enseñanza, los participantes mostraron mayor número de aciertos en las tareas evaluadas, independientemente del tipo de estímulo o valencia emocional, lo que genera una oportunidad para la generalización del aprendizaje de reconocimiento y denominación de emociones, además de consolidar la viabilidad de estrategias de enseñanza mediadas por recursos tecnológicos y aplicadas por la familia.

Registros políticos do sofrimento: identidade, trauma e transformação / Political registers of suffering: Identity, trauma, and transformation / Registres politiques de la souffrance: identité, trauma et transformation / Registros políticos del sufrimiento: identidad, trauma y transformación

Neste artigo apresentaremos algumas incidências sociais do sofrimento psíquico, suas valências políticas, formas de resistência e potencialidades transformativas. Distintas expressões e produções sociais de sofrimento no contexto brasileiro contemporâneo ligadas a gênero, sexualidade, raça e violência serão mobilizadas para uma análise a partir dos registros lacanianos de Real, Simbólico e Imaginário. Discutiremos a identitarização do sofrimento como uma estratégia de denúncia que tem na fixação traumática seu limite; a banalização da contingência no silenciamento de violências como efeitos de colonizações entre os eixos imaginário e real; e, por fim, a apresentação da espessura sintomática do sofrimento permitirá a utilização do registo simbólico como matriz de um horizonte de transformação social que se valha do passado para a construção de um futuro de liberdade ligado ao desejo.

Resumos In this paper, we will present some social occurrences of psychological suffering, their political implications, means of resistance, and transformative potentials. Different expressions and social productions of suffering in the contemporary Brazilian context related to gender, sexuality, race, and violence are mobilized for an analysis based on Lacanian registers of the Real, the Symbolic, and the Imaginary. We will discuss the identitarization of suffering as a denunciation strategy that has traumatic fixations as its limit; the banalization of contingency in the silencing of violence as effects of the colonization between the imaginary and the real axes; and finally, a presentation of the symptomatic structure of suffering will allow the use of the symbolic register as the matrix for a horizon of social transformation that articulates history and desire.

Dans cet article, nous présenterons quelques incidences sociales de la souffrance psychique, leurs dimensions politiques, formes de résistance et potentiel de transformation. Différentes expressions et productions sociales de la souffrance dans le contexte brésilien contemporain, liées au genre, à la sexualité, à la race et à la violence, seront mobilisées pour être analysées à partir des registres lacaniens du Réel, du Symbolique et de l'Imaginaire. Nous discuterons la tournant identitaire de la souffrance comme stratégie de dénonciation qui trouve ses limites dans la fixation traumatique; de la banalisation de la contingence dans le silence sur les violences comme effets de la colonisation entre les axes imaginaire et réel; finalement, la presentation de l'épaisseur symptomatique de la souffrance permettra l'utilisation du registre symbolique comme matrice pour un horizon de transformation sociale qui s'appuie sur le passé pour construire un avenir de liberte lié au désir

En este artículo presentaremos algunas manifestaciones sociales del sufrimiento psicológico, sus implicaciones políticas, modos de resistencia y potencialidades transformadoras. Se examinarán diferentes expresiones y producciones sociales del sufrimiento en el contexto contemporâneo de Brasil relacionadas con género, sexualidad, raza y violencia utilizando los registros lacanianos de lo real, lo simbólico y el imaginario. Discutiremos la identitarización del sufrimiento como una estrategia de denuncia que tiene como límite la fijación traumática; la banalización de la contingencia en el silenciamiento de la violencia como efectos de colonización entre los ejes imaginario y real; y, por último, la presentación de la espesura sintomática del sufrimiento permitirá la utilización del registro simbólico como matriz para un horizonte de transformación social que toma el pasado para construir un futuro de libertad articulado al deseo.

Thoughts on Ethical Collaborative Review and Management of Multi-center Clinical Research / 中国医学伦理学

For multi-center clinical research, how to ensure the quality of ethical review and improve the efficiency of ethical review through cooperation among centers is an important direction for clinical research management departments and research parties to explore. By combing and analyzing the existing pattern of multi-center ethical review at home and abroad, combining the current situation of the ethical review and management development in China, taking cancer clinical research as the breakthrough point, it was advocated to establish a cooperative review led by professional institute in domestic, on the basis of extensive and in-depth training exchanges and effective communication on the same platform, collaborative review, ensure quality and efficiency, so as to promote and implement the "mutual recognition" of ethical review. Then, this paper further put forward the concept of "whole-process linkage" in the ethical management process of multi-center clinical research, and pointed out that all research parties should clarify their responsibilities, enhance their awareness and ability, and jointly and comprehensively implement the protection of subjects among clinical researchers.

Research on the Moral Responsibility of Face Recognition and Medical Diagnosis / 中国医学伦理学

The application of face recognition technology is gradually expanding to the medical field. It has been initially used in the medical diagnosis of endocrine diseases and genetic syndrome. This technology is expected to be used for the screening of genetic syndrome and endocrine diseases, shortening the delay period of disease diagnosis and helping the staging of endocrine diseases. However, this technology also has some moral risks, such as the risk of personal information security disclosure, the challenge to the future of mankind and the division of moral responsibility. This paper reflected on the dilemma of moral responsibility in the application of face recognition and medical diagnosis, and explored the two basic problems of "who is the subject of moral responsibility" and "the specific division of moral responsibility of different moral subjects" in face recognition and medical diagnosis. Finally, some suggestions on the moral responsibility in face recognition and medical diagnosis are put forward. The first is to determine the role of face recognition and medical diagnosis as an auxiliary category, and doctors are still the main medical subject; the second is to build the responsibility ethics mechanism and laws and regulations, the establishment of the responsibility system of face recognition and medical diagnosis is inseparable from the joint action of law and ethics.

Face, facial recognition technology and personal privacy

The privacy problem of facial recognition technology is that commercial companies obtain people's facial information without the consent of individuals and use facial information to infringe on the privacy of individuals. The importance of human privacy in facial recognition technology is reflected through facial ethics, which requires others to perform corresponding obligations to individuals, such as oral care. Through the analysis of the privacy issues of facial recognition technology, it is found that the two elements of "without personal informed" and "without personal consent" together form the basis for commercial companies to violate personal privacy. The principle of informed consent includes the principle of informed and the principle of consent, which is derived from the principle of informed consent in medical ethics. This paper improves the principles of informed consent in medicine and ethics to better address facial recognition privacy issues.

El problema de la privacidad en la tecnología de reconocimiento facial es que las empresas comerciales obtienen información facial de las personas sin el consentimiento de éstas y utilizan la información facial para vulnerar la privacidad de las personas. La importancia de la privacidad de las personas en la tecnología de reconocimiento facial se refleja a través de la ética facial, que exige que otros cumplan las obligaciones correspondientes con los individuos, como el cuidado bucal. A través del análisis de los problemas de privacidad de la tecnología de reconocimiento facial se descubre que los dos elementos de "sin información personal" y "sin consentimiento personal" juntos forman la base para que las empresas comerciales violen la privacidad personal. El principio de consentimiento informado incluye el de información y el de consentimiento, que se deriva del principio de consentimiento informado de la ética médica. Este artículo mejora los principios del consentimiento informado en medicina y ética para abordar mejor los problemas de privacidad del reconocimiento facial.

A questão da privacidade na tecnologia de reconhecimento facial é que as companhias comerciais obtém informações faciais das pessoas sem seu consentimento e usam informação facial para infringir sua privacidade. A importância da privacidade humana na tecnologia de reconhecimento facial é refletida através da ética facial, que exige que se cumpram obrigações correspondentes para com os indivíduos, da mesma forma como com cuidados orais. Através da análise de aspectos de privacidade na tecnologia de reconhecimento facial, encontrou-se que os dois elementos "sem informação pessoal" e "sem consentimento pessoal" juntos, formam a base para companhias comerciais violarem a privacidade pessoal. O princípio do consentimento informado inclui o princípio de informação e o princípio de consentimento, os quais derivam do princípio do consentimento informado em ética médica. Esse artigo melhora os princípios do consentimento informado em medicina e ética para melhor incluir aspectos de privacidade no reconhecimento facial.

Propiedades psicométricas de una tarea computarizada Stroop emocional caras y palabras

Objetivo: Determinar las propiedades psicométricas de una tarea computarizada de Stroop de reconocimiento emocional de caras y palabras en población colombiana. Método: La investigación fue de naturaleza cuantitativa, con un diseño de investigación instrumental de tipo psicométrico y de desarrollo tecnológico. La muestra se seleccionó por conveniencia, estuvo conformada por 1172 participantes (56,6 % mujeres, 43,4 % hombres), con edades entre 18 a 25 años quienes ingresaban a un dominio para contestar la tarea después de leer y aceptar el consentimiento. Resultados: Los resultados obtenidos demuestran una consistencia interna favorable con un KR-20=0,853 y un coeficiente Omega de McDonald=0,859, una validez de constructo, a partir de un análisis factorial exploratorio y análisis factorial confirmatorio, que presenta una estructura de seis factores y explica un 50,32 % de la varianza; además, de una validez convergente con un coeficiente de correlación Spearman positivo de 0,522 %; los índices de confiabilidad y validez obtenidos en el presente estudio hacen de esta versión computarizada una prueba que puede ser usada en el ámbito de la evaluación de procesos de atención, memoria de trabajo e inhibición en población adulta colombiana no clínica. Conclusiones: En conclusión, se observó efectivamente que la configuración del instrumento psicológico en un software informático optimiza la recolección de datos, pues hay más precisión en la medición de latencias de respuestas, así mismo facilita el análisis de los datos.

Objective: To determine the psychometric properties of a computerized Stroop task of emotional recognition of faces and words in a Colombian population. Method: The research was quantitative in nature with an instrumental design of a psychometric type and technological development. The sample was selected for convenience. It was made up of 1172 participants (56,6 % women, 43 % men) between 18 and 25 years of age. They entered a domain to answer the task after reading and giving consent. Results: The results showed a favorable internal consistency with a KR-20=0,853 and a McDonald's Omega coefficient=0,859. A construct validity was obtained from an exploratory factor analysis and a confirmatory factor analysis which presents a structure of six factors and explains 50,32 % of variance. In addition, it presents a convergent validity with a positive Spearman correlation coefficient of 0,522. The reliability and validity indices obtained in the present study make this computerized version a test that can be used in the field of evaluation of processes of attention, working memory and inhibition in non-clinical Colombian adult population. Discussions: In conclusion, it was effectively observed that the configuration of the psychological instrument in computer software optimizes data collection since there is more precision in the measurement of response latencies, as well as facilitating data analysis.

Objetivo: Determinar as propriedades psicométricas de uma tarefa Stroop computadorizada de reconhecimento emocional de rostos e palavras em uma população colombiana. Metologia: A pesquisa era de natureza quantitativa, com um projeto de pesquisa instrumental de tipo psicométrico e de desenvolvimento tecnológico. A amostra foi selecionada por conveniência e consistiu de 1172 participantes (56,6 % mulheres, 43,4 % homens), com idades entre 18 e 25 anos, que entraram em um domínio para responder à tarefa após a leitura e aceitação do termo de consentimento. Resultados: Os resultados obtidos mostram uma consistência interna favorável com um coeficiente KR-20=0,853 e McDonald's Omega = 0,859, A validade da construção foi obtida a partir de uma análise exploratória de fatores e análise confirmativa de Fatores, que apresenta uma estrutura de seis fatores e explica 50,32 % da variação, e validade convergente com um coeficiente de correlação Spearman positivo de 0,522. Os índices de confiabilidade e validade obtidos no presente estudo fazem desta versão computadorizada um teste que pode ser usado na avaliação da atenção, memória de trabalho e processos de inibição na população adulta colombiana não-clínica. Conclusões: Em conclusão, foi realmente observado que a configuração do instrumento psicológico em um software de computador otimiza a coleta de dados, pois há maior precisão na medição das latências de resposta, além de facilitar a análise dos dados.

CONTEXTUAL LEARNING APPROACH FOR SYNDROME DISEASE NAMED ENTITY RECOGNITION

The groundwork for extracting a significant amount of biomedical information from unstructured texts into structured formats is the difficult research area of biological entity recognition from medical documents. The existing work implemented the named entity recognition for diseases using the sequence labelling framework. The performance of this strategy, however, is not always adequate, and it frequently cannot fully exploit the semantic information in the dataset. The Syndrome Diseases Named Entity problem is presented in this work as a sequence labelling with multi-context learning. By using well-designed text/queries, this formulation may incorporate more previous information and to decode it using decoding techniques such conditional random fields (CRF). We performed experiments on three biomedical datasets, and the outcomes show how effective our methodology is on the BC5CDR-Disease, JNLPBA and NCBI-Disease, compared with other techniques our methodology performs with accuracy levels of 96.70%,98.65 and 96.72% respectively.

Enfrentamiento de la anafilaxia en el servicio de urgencia / Approach of Anaphylaxis in the emergency room

La anafilaxia es una reacción en su mayoría de hipersensibilidad tipo I, que estimula la activación generalizada de mastocitos, y provoca un cuadro clínico multisistémico que puede ser fatal. Se estima que tiene una incidencia de 0,03-0,1% y una prevalencia de vida de 0,5-2% en la población general. Generalmente, la reacción inmunológica ocurre posterior a la ingesta de alimentos, uso de medicamentos o picaduras de insectos, pero también se han descrito mecanismos no inmunológicos (no IgE) que actúan directamente sobre los mastocitos, llamadas en la literatura "reacciones anafilactoideas". La anafilaxia fue descrita por Paul Portier y Charles Robert Richet en 1902 en perros, los cuales desarrollaban esta reacción posterior a la inyección repetida de veneno de anémonas (medusas). Sin embargo, esta entidad no tuvo criterios diagnósticos ni pilares de manejo estructurado hasta el año 2006. En ese año en se publicó el segundo simposio de manejo de la anafilaxia, en donde se definieron criterios diagnósticos clínicos claros y el rol fundamental de la adrenalina en su manejo; la única droga que cambia el pronóstico del paciente.

Anaphylaxis is mainly a type I hypersensitivity reaction. It triggers a widespread activation of mast cells, causing a multisystemic clinical scenario that can be fatal. It is estimated to have an incidence of 0.03-0.1% and a lifetime prevalence of 0.5-2%. Most immunological reactions occur after food ingestion, medication, or insect stings, but non-immunological (non-IgE) mechanisms that act directly on mast cells, called Anaphylactoid Reactions, have been also described. Anaphylaxis was described by Paul Portier and Charles Robert Richet in 1902 in dogs, that developed this disease after repeated injections of anemones (jellyfish) venom. However, this entity didn't have established diagnostic criteria or an standarized management until 2006. In this year, the second anaphylaxis management sym-posium took place and clear clinical diagnostic criteria were defined. The fundamental role of adrenaline in its management was also established. The former is the only drug that has demonstrated to improve prognosis of the patient

Association between Sleep Quality and Different Aspects of Memory along with Assessment of Post Exercise and Post Meditation Effects

Background and Aims : Sleep is a highly conserved behaviour across animal evolution. The functions of sleep include restoration, memory processing, dreaming etc. Memory is informational processing system with explicit and implicit functioning made up of sensory processor, short term memory and long term memory. The present study was designed to analyse the impact of sleep quality on memory and effect of exercise and meditation on same. Material and Method : The present study was performed on 110 subjects chosen randomly with no gender bias. In first phase, baseline values were assessed for different sub tests of sleep quality and different aspects of memory. Subjects were divided into two groups with each group including 27 males and 27 females. One group was required to perform moderate intensity exercise and other meditation for one month duration. In the second phase, parameters were again assessed. Statistical analysis : Paired t-test was used for comparison of memory and sleep components between males and females. Independent t-test was used between baseline and post intervention values of exercise, meditation. Correlation studies were also carried out between sleep quality and different aspects of memory using Pearson correlation coefficient. Result : Significant and non significant results were obtained on comparison of memory and sleep components in males and females. Total memory score was better in females. Exercise and meditation exhibited statistically significant result on memory and sleep quality. Conclusion : Good sleep quality is associated with better memory. There is improvement across domains of memory and sleep with meditation and exercise.

Effect of pupil dilation on biometric iris recognition systems for personal authentication

Purpose: To study the effect of pupil dilation on a biometric iris recognition (BIR) system for personal authentication and identification. Methods: A prospective, non?randomized, single?center cohort study was conducted on patients who reported for a routine eye check?up from November 2017 to November 2019 (2 years). An iris scanning device “IRITECH?MK2120U” was used to initially enroll the undilated eyes. Baseline scans were taken after matching with the enrolled database. All eyes were topically dilated and matched again with the enrolled database. The Hamming distance (a measure of disagreement between two iris codes) and recognition status were recorded from the device output, and eyes were evaluated by slit?lamp ophthalmoscopy with special emphasis on pupil shape, size, and texture. Results: All 321 enrolled eyes matched after topical dilation. The pupil size had a significant effect on Hamming distance with a P value <0.05. There were no false matches. A correct recognition rate of 100% was obtained after dilation. No loss of iris texture or pupil shape was observed after dilation. Conclusion: A BIR system is a reliable method for identification and personal authentication after pupil dilation. Topically dilated pupils are not a cause for non?recognition of iris scans.

3D Bitemark Analysis in Forensic Odontology Utilizing a Smartphone Camera and Open-Source Monoscopic Photogrammetry Surface Scanning

Abstract Bitemark analysis is a challenging procedure in the field of criminal case investigation. The unique characteristics of dentition are used to find the best match between the existing patterned injury and the suspected perpetrator in bitemark identification. Bitemark analysis accuracy can be influenced by various factors, including biting pressure, tooth morphology, skin elasticity, dental cast duplication, timing, and image quality. This review article discusses the potential of a smartphone camera as an alternative method for 3D bitemark analysis. Bitemark evidence on human skin and food should be immediately recorded or duplicated to retrieve long-lasting proof, allowing for a sufficient examination period. Various studies utilizing two-dimensional (2D) and three-dimensional (3D) technologies have been developed to obtain an adequate bitemark analysis. 3D imaging technology provides accurate and precise analysis. However, the currently available method using an intraoral scanner (IOS) requires high-cost specialized equipment and a well-trained operator. The numerous advantages of monoscopic photogrammetry may lead to a novel method of 3D bitemark analysis in forensic odontology. Smartphone cameras and monoscopic photogrammetry methodology could lead to a novel method of 3D bitemark analysis with an efficient cost and readily available equipment.

Limite ético para confirmar identidade pelos caracteres morfológicos / Ethical limits to confirming identity by morphological features / Límite ético para confirmar la identidad por caracteres morfológicos

Resumo O desenvolvimento de novas tecnologias fez nascer ferramentas que auxiliam no processo de identificação de indivíduos, possibilitando confirmar identidades e ajudando a solucionar crimes, ao permitir confirmar o encontro de pessoas desaparecidas ou vítimas de acidentes, por exemplo. Entretanto, um importante questionamento ético precisa ser observado: os fins sempre justificam os meios? A identificação facial a partir de imagens coletadas por câmeras de circuito fechado de televisão ou a análise de registros fotográficos são capazes de confirmar a identidade de alguém inequivocamente? Impressões digitais ou labiais podem ser utilizadas, em qualquer hipótese, em um confronto dactiloscópico? O conhecimento sobre as limitações dos métodos técnicos científicos utilizados em comparações de caracteres morfológicos permite que o resultado do perito papiloscopista atenda a dois princípios basilares constitucionais: a legalidade e o direito da pessoa humana. Ao respeitá-los, estará agindo conforme os limites éticos.

Abstract Technological advancements have generated tools to help with identifying individuals, allowing to verify identities and solve crimes by confirming found missing persons or accident victims, for example. An important ethical question, however, arises: do the ends always justify the means? Can facial identification from images collected by closed-circuit television cameras or analysis of photographic records confirm someone's identity unequivocally? Can fingerprints or lip prints be used for any dactyloscopy? Knowing the limitations of scientific technical methods used in morphological comparisons allows examiners to comply with two fundamental constitutional principles: that of legality and right of the human person. By respecting them, examiners will be acting according to ethical limits.

Resumen El desarrollo de nuevas tecnologías dio lugar a herramientas que ayudan en el proceso de identificación de personas, lo que posibilita la confirmación de identidades y contribuye a la resolución de delitos al permitir confirmar, por ejemplo, a personas desaparecidas o víctimas de accidentes. Sin embargo, es necesario observar una cuestión ética importante: ¿el fin siempre justifica los medios? ¿La identificación facial desde imágenes captadas por cámaras de circuito cerrado de televisión o el análisis de registros fotográficos puede confirmar inequívocamente la identidad de una persona? ¿Se pueden utilizar huellas dactilares o labiales, bajo cualquier circunstancia, en un enfrentamiento dactiloscópico? El conocimiento sobre las limitaciones de los métodos técnicos y científicos utilizados en las comparaciones de caracteres morfológicos permite que el resultado del perito en papiloscopía responda a dos principios constitucionales básicos: la legalidad y el derecho de la persona humana. Al respetarlos se estará actuando dentro de los límites éticos.

Advances in social cognition of obsessive-compulsive disorder / 中华行为医学与脑科学杂志

The main clinical features of obsessive-compulsive disorder (OCD) are obsessions and/or compulsions. Due to its symptoms are heterogeneous and have a wide range of influences, OCD usually causes different degrees of damage to patients' social functions. Social cognition is the process of perceiving and judging the psychology and behavior of others or oneself. Its core is to understand the information processing process and the underlying mechanism of social psychological phenomena. Studies have shown that social cognitive deficits can affect an individual's social function. Therefore, many scholars believe that the social cognitive function of OCD patients are impaired. Through collecting and sorting out relevant literature, we find that OCD patients can’t perceive social cues accurately, and they have trouble recognizing their own emotions and those of others. In general, they are not prone to emotional response, that is, their ability of emotional experience is impaired, while because of their own emotional regulation dysfunction, they overreact to special events that can induce the obsession and/or compulsion.The patients have poor insight into the mental states of others.The researches on attributions of life events are dificient, so their characteristics of attribution styles are not yet clear.These findings provide a preliminary theoretical basis and reference for the specificity of social cognitive impairment in patients with OCD and for guiding clinical effective and precise intervention.

The role of myocardial work parameters in early identification of myocardial injury in neonatal asphyxia / 中国新生儿科杂志

Objective:To study the role of myocardial work parameters in early identification of myocardial injury in neonatal asphyxia.Methods:From July 2020 to December 2021, neonates diagnosed with mild neonatal asphyxia admitted to the Department of Neonatology of our hospital within 24 h after birth were prospectively enrolled into the asphyxia group. Neonates without asphyxia during the same period were selected as the control group and matched with the asphyxia group for gender, gestational age and birth weight at a ratio of 1:1~1:2. The asphyxia group was subgrouped into preterm asphyxia group and term asphyxia group. All neonates received echocardiography within 24 h after birth. Multiple parameters were measured including M-mode, two-dimensional image, Doppler image, global longitudinal strain (GLS) and myocardial work parameters [global work index (GWI), global constructive work (GCW), global wasted work (GWW), global work efficiency (GWE)]. The level of serum N-terminal pro brain natriuretic peptide (NT-proBNP) was recorded in the asphyxia group. The data were compared between the asphyxia group and the control group. Correlations between myocardial work parameters and other parameters were analyzed.Results:A total of 33 cases were in the asphyxia group and 43 cases were in the control group. The preterm asphyxia group (18 cases) showed significantly lower GWI and GCW than the preterm control group (18 cases) [GWI: (702±153) mmHg vs. (879±205) mmHg, GCW: (1 016±221) mmHg vs. (1 200±271) mmHg] ( P<0.05). No differences existed in GLS, GWW and GWE. The term asphyxia group (15 cases) showed significantly lower GWW than the term control group (25 cases) [45.0 (30.0, 65.0) mmHg vs. 71.0 (35.5,85.5) mmHg] ( P<0.05). No differences existed in GLS, GWI, GCW and GWE. GWI was negatively correlated with serum NT-proBNP level ( r=-0.327, P<0.05). Conclusions:GWI and GCW may indicate myocardial injury in preterm neonates with mild asphyxia.

Study on comprehensive quality evaluation of Sargentodoxae Caulis from different habitats / 国际中医中药杂志

Objective:To comprehensively evaluated the quality of Sargentodoxae Caulis from different habitats with a combination of indexes and characteristic chromatogram method from Chinese Pharmcopoeia (Edition 2020). Methods:The contents of water content, total ash, ethanolic extract, sulfur dioxide residue, heavy metals and harmful elements, total phenols, chlorogenic acid, salidroside and characteristic chromatogram of 17 batches of Sargentodoxae Caulis were determined. The quality of Sargentodoxae Caulis was comprehensively evaluated by combining chemical pattern recognition method. Results:The water content, total ash content, extracts, and content determination of 17 batches of Sargentodoxae Caulis from different habitats complyed with the provisions of the Chinese Pharmcopoeia (Edition 2020). There were differences in the contents of extracts, chlorogenic acid, and salidroside, among which the content of Anhui origin was higher. A total of 8 common peaks were identified from the 17 batches samples. Conclusion:Comprehensive evaluation of multiple indicators can demonstrate the quality of Sargentodoxae Caulis more correctly, and shows that the quality of Sargentodoxae Caulis from different habitats is different. The quality of Sargentodoxae Caulis from Anhui is better than that from other habitats.

Human Telomeric i-motif: Its Structure‚ Recognition and Physiological Activity / 中国生物化学与分子生物学报

The human telomeric i-motif (htel-iM) is a unique higher-order DNA structure formed by the cytosine-rich (C) sequences at the end of human telomeres. Studies have shown that htel-iM plays a significant role in the transcriptional regulation of telomeric repeat-containing RNA (TERRA) ‚ maintenance of telomere function and inhibition of telomerase activity. Thus‚ it is closely related to the development and progression of many cancers and is a promising new target for cancer treatment therapy. Compared to other nucleic acid higher-order structures such as G-quadruplexes‚ the stability of htel-iM is much weaker and affected by many factors like buffer pH‚ ionic conditions and molecular crowding environments. Therefore the existence of the iM structures in near neutral physiological conditions has been uncertain for a long time. Recently‚ using in-vitro screened small molecule ligands to selectively recognize and stabilize htel-iM provides a new strategy for the exploration of the biological relevance of htel-iM. Thus it has become a research hotspot to take telomere as a cancer treatment target. However‚ so far the reported small molecule ligands selectively targeting the htel-iM are far from sufficient compared with those targeting other higher-order nucleic acid structures. In this review‚ the discovery and the characteristic of the iM structures are briefly described‚ with an emphasis on the in-vitro affecting factors of the htel-iM structure‚ the reported htel-iM ligands and its biological relevance and regulation mechanisms‚ which will be helpful in further exploration of the htel-iM structure and ligand screening in near physiological conditions‚ and understanding the mechanism and developing novel therapeutic strategies for cancer treatment targeting the htel-iM structures.

Microbial sensing in the intestine

The gut microbiota plays a key role in host health and disease, particularly through their interactions with the immune system. Intestinal homeostasis is dependent on the symbiotic relationships between the host and the diverse gut microbiota, which is influenced by the highly co-evolved immune-microbiota interactions. The first step of the interaction between the host and the gut microbiota is the sensing of the gut microbes by the host immune system. In this review, we describe the cells of the host immune system and the proteins that sense the components and metabolites of the gut microbes. We further highlight the essential roles of pattern recognition receptors (PRRs), the G protein-coupled receptors (GPCRs), aryl hydrocarbon receptor (AHR) and the nuclear receptors expressed in the intestinal epithelial cells (IECs) and the intestine-resident immune cells. We also discuss the mechanisms by which the disruption of microbial sensing because of genetic or environmental factors causes human diseases such as the inflammatory bowel disease (IBD).

Molecular dynamics simulation reveals DNA-specific recognition mechanism via c-Myb in pseudo-palindromic consensus of mim-1 promoter / 浙江大学学报（英文版）（B辑：生物医学和生物技术）

This study aims to gain insight into the DNA-specific recognition mechanism of c-Myb transcription factor during the regulation of cell early differentiation and proliferation. Therefore, we chose the chicken myeloid gene, mitochondrial import protein 1 (mim-1), as a target to study the binding specificity between potential dual-Myb-binding sites. The c-Myb-binding site in mim-1 is a pseudo-palindromic sequence AACGGTT, which contains two AACNG consensuses. Simulation studies in different biological scenarios revealed that c-Myb binding with mim-1 in the forward strand (complex F) ismore stable than that inthereverse strand (complex R). The principal component analysis (PCA) dynamics trajectory analyses suggested an opening motion of the recognition helices of R2 and R3 (R2R3), resulting in the dissociation of DNA from c-Myb in complex R at 330 K, triggered by the reduced electrostatic potential on the surface of R2R3. Furthermore, the DNA confirmation and hydrogen-bond interaction analyses indicated that the major groove width of DNA increased in complex R, which affected on the hydrogen-bond formation ability between R2R3 and DNA, and directly resulted in the dissociation of DNA from R2R3. The steered molecular dynamics (SMD) simulation studies also suggested that the electrostatic potential, major groove width, and hydrogen bonds made major contribution to the DNA‍-specific recognition. In vitro trials confirmed the simulation results that c-Myb specifically bound to mim-1 in the forward strand. This study indicates that the three-dimensional (3D) structure features play an important role in the DNA-specific recognition mechanism by c-Myb besides the AACNG consensuses, which is beneficial to understanding the cell early differentiation and proliferation regulated by c-Myb, as well as the prediction of novel c-Myb-binding motifs in tumorigenesis.