RESUMEN
Systemic lupus erythematosus,anti-neutrophil cytoplasmic antibodies associated vasculitis,thrombotic microangiopathy,Henoch schonlein purpura,Guillain-Barre syndrome and myastheniagravis are common rheumatic autoimmune diseases in children. Severe cases can be life-threatening,and medication is sometimes ineffective in controlling the condition. In recent years,blood purification therapy has been widely used in pediatric rheumatic autoimmune disease. This paper reviews the new clinical research,consensus and guidelines.
RESUMEN
Biological agents has opened a new chapter in the targeted therapy of rheumatism,and provides a new choice for the rheumatism children who is refractory to traditional disease-modifying antirheumatic drugs.This article described the classification,application,efficency,side effects and precautions of the cytokines antagonists and the cell targeting biological agents,to provide a reference for rational application in clinical work.