Clinical effects of isotretinoin combined with anti-sensitive moisturizing tolerance-extreme cream on severe acne / 中华医学美学美容杂志

Objective:To observe the efficacy of anti-sensitive moisturizing tolerance-extreme cream combined with isotretinoin in the treatment of severe acne.Methods:Fifty patients with severe acne were selected in the Dermatology Clinic of the Third People＇s Hospital of Hangzhou from November 2018 to July 2019. They were randomly divided into the experimental group of 25 cases and the control group of 25 cases. The experimental group was treated with anti-sensitive moisturizing tolerance-extreme cream combined with isotretinoin orally. The control group was treated with isotretinoin orally alone. Before and after treatment for 56 days, lactate score, skin cuticle hydration (SCH), transepidermal water loss (TEWL) and skin physiological indexes were measured.Results:After 56 days of treatment, the TEWL and SCH of the control group were 15.75±3.31 and 10.13±3.62, the TEWL and SCH of the experimental group were 12.17±3.61 and 28.07±3.17, respectively; the difference was statistically significant ( T was 3.610 and 12.398, P was 0.002 and 0.000, respectively). The volume and depth of cyst nodule, scar depression, skin roughness, absolute value and area of erythema in the experimental group were significantly lower than those in the control group ( T was 2.280, 1.676, 2.332, 1.508, 4.813 and 3.637; P was 0.031, 0.011, 0.027, 0.040, 0.000 and 0.001, respectively). Conclusions:Anti-sensitive moisturizing tolerance-extreme cream combined with isotretinoin has a good effect on severe acne and it can reduce the barrier damage and other adverse reactions.

The Analysis of Therapy in 3 012 Severe Acne Patients / 天津医药

Objective To analyze the current clinic application of severe acne treatment, and to provide evidences to improve its treatment. Methods Using sampling survey, a total of 3 012 severe acne patients who visited the dermato-logical department of 35 hospitals over the country for the first time were selected for this study. Each patient filled a ques-tionnaire about their acknowledgement, history of medical intervention and drug therapy of severe acne. Results Among all 3 012 patients with severe acne, 76.6%believed acne is a kind of skin disease, but only 35.2%of the patients went to see doctors at early stage of disease, while others choose interventions such as self-extrudation , topical medication or skin care products, herbal tea/folk recipes, beauty salons and application of coverture cosmetics. Among all severe acne patients, 2 388 cases (79.3%)had taken oral medications, which included 1 161(48.6%) patients who took anti-biotics. 394 cases (33.9%) took roxithromycine and 173 cases(14.9%) took other kinds of anti-biotics. 55.5%of all these patients who took oral medication less than 4 weeks in duration. 2 081 cases (69.1%) applied external drugs, in which includes 90 cases (4.3%) of using glucocorticoid, and 437 cases (21.0%) of using other kinds of external products. The adverse effects of topical treat-ments were commonly observed, such as erythema (512 cases, 24.6%), desquamation (683 cases, 32.8%), scab (73 cases, 3.5%) and hypersensitive (281 cases, 13.5%). Conclusion Severe acne is a disease need systematic treatment. but only mi-nority of the patients went to see doctors at early stage of disease. The current problems in treatment of severe acne include lack of target in choosing drugs, not long enough treatment course, and adverse effects of cutaneous administration.Early , safe and targeted medical attention with sufficient treatment course is encouraged.

Acne: um tratamento para cada paciente / Acne: a treatment for each patient

Acne é uma dermatose de alta prevalência, especialmente em adolescentes e adultos jovens. Acomete homens e mulheres, mas geralmente os homens são afetados pelas formas mais graves da acne. Muitas vezes os pacientes são inicialmente avaliados pelo clínico ou pediatra. Diversas opções terapêuticas estão disponíveis, desde os esfoliantes, antibióticos tópicos e sistêmicos até a isotretinoína sistêmica. A opção terapêutica depende da forma clínica da acne, sua gravidade e algumas características individuais, como adesão ao tratamento e desejo de gestação. A terapia costuma ser de longa duração. O objetivo deste artigo é esclarecer ao médico generalista as nuances da acne e seu tratamento, avaliando o custo e o benefício das terapêuticas disponíveis.

Acne is a prevalent disorder especially in adolescents and young adults. Severe acne is more common in male patients. Usually, patients are initially seen by the clinicians or by the pediatricians. Several therapeutic options are available from exfoliating products, topical and systemic antibiotic to systemic isotretinoin. A few factors must be considered when treating acne: clinical presentation, severity and individual characteristics such as therapy adhesion and pregnancy. The goal of this paper is to clarify to the general practitioners the clinical spectrum of acne and its treatment, taking into account cost and efficacy.

Cost-Minimization Analysis of 3 Therapeutic Regimens for Severe Acne / 中国药房

0.05),and the costs were 437.54 yuan,492.24 yuan and 262.84 yuan,respectively. CONCLUSION:Ethinylestradiol cyproterone is the most economical therapeutic regimen for the indicated severe acne cases.