RESUMEN
The surface and interface,as the transition region between two phases,belongs to the category of physical chemistry.At present,it is widely used in materials and other scientific fields.Meanwhile,this property also plays an important role in pharmaceutical research.The interface layer involved in the progress of pharmaceutical preparations is connected with the two-phase or three-phase between gas,liquid and solid closely.The interface effect will affect the final shaping of pharmaceutical preparations and the dissolution and absorption of drugs in the human body.In this paper,the surface and interface characteristics(specific surface area,surfacial and interfacial tension and surface Gibbs free energy) were compared,and the application of interface phenomena(wetting,solubilization and emulsification) in pharmaceutical research were introduced.From the points of view of the progress control of pharmaceutical preparations and the effectiveness of their products,the article expounds the important role of properties of surface and interface in the field of pharmaceutical preparations.Therefore,it is necessary to pay attention to the properties of surface and interface,one of the key physical properties of drugs,and to apply them in the pharmaceutical research.
RESUMEN
The activated carbon with high specific surface area was prepared by carbonization with walnut shell as raw material and activation by potassium hydroxide.The surface of activated carbon was then modified by phenyltrimethoxysilane to prepare phenyl-bonded high specific surface area activated carbon adsorption material.The specific surface area and pore size distribution of phenyl-bonded activated carbon were measured by nitrogen adsorption method.The organic functional groups of the phenyl-bonded activated carbon, the chemical environment of the surface elements and the crystal structure were characterized by infrared spectroscopy, X-ray photoelectron spectroscopy and X-ray powder diffraction method.The volatile organic compounds (VOCs) in the air were absorbed by a sampling tube filled with the adsorption material prepared here, then desorbed into carbon disulfide solution and detected by gas chromatography.The saturated adsorption capacities of phenyl bonded activated carbon to 7 kinds of VOCs (ethanol, acetone, hexane, ethyl acetate, tetrahydrofuran, 1,2-dichloroethane, benzene) were in the range of 129-216 mg/g.In the range of 0.05-2.50 mg/mL, there was a good linear relationship between the peak height of the 7 components and the concentration, and the detection limits were in the range of 0.92-3.60 mg/m3.
RESUMEN
Objective: To explore a method to improving the in vitro dissolution of tanshinone IIA spray drying powder and to study its pharmceutical properties. Methods: Tanshinone IIA was processed with spray drying method and analyzed by determination of the specific surface area (BET), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray powder diffraction (XRPD). And in vitro dissolution and drug stability were also investigated. Results: The BET results showed that tanshinone IIA powder after spray drying had narrow particle size distribution range and large specific surface area; XRD and DSC analyses showed that most drug was transformed into amorphous form. The in vitro dissolution achieved 85.2% within 8 h. Accelerating experiment showed that the in vitro dissolution of tanshinone IIA decreased by approximately 21% stored for 6 months. Conclusion: The drug dissolution is improved by spray-drying method. It provides a reference for the research and development of poorly soluble pharmaceutical preparations for oral administration.