Pyoderma gangrenosum: A clinico-epidemiological study.

Background: Pyoderma gangrenosum is a neutrophilic dermatosis of unknown etiology, with inconstant systemic associations and a variable prognosis. Aims: To study the clinical features and systemic associations of pyoderma gangrenosum and its response to treatment. Methods: All patients diagnosed to have pyoderma gangrenosum at the dermatology department of the Government Medical College, Kozhikode, from January 01, 2005 to December 31, 2014 were included in this prospective study. Results: During the 10-year study period, 61 patients were diagnosed to have pyoderma gangrenosum. A male predilection was noted. The most common clinical type was ulcerative pyoderma gangrenosum (90.2%). More than 60% of patients had lesions confi ned to the legs; 78.7% had a single lesion and 27.9% had systemic associations. Most patients required systemic steroids. Patients with disease resistant to steroid therapy were treated with intravenous immunoglobulin G and split-thickness skin grafts under immunosuppression induced by dexamethasone pulse therapy. All except one patient attained complete disease resolution. Limitations: The main limitation of our study was the small sample size. Conclusions: The male predilection documented by us was contrary to most previous studies. We found split-thickness skin graft to be a useful option in resistant cases. More prospective studies may enable the formulation of better diagnostic criteria for pyoderma gangrenosum and improve its management.

Determinación de la prevalencia y etiología de las parálisis oculomotoras en un consultorio particular de ortoptica en la ciudad de Bogotá entre los años 2004 y 2006 / Determination of the prevalence and etiology of the oculomotor paralysis in a private doctor’s office of orthoptic in Bogota between 2004 and 2006

Las parálisis oculomotoras son una perdida total de la función de un músculo ocular. El objetivo del presente trabajo fue establecer la prevalencia de las parálisis oculomotoras en la consulta ortóptica, definir los signos y síntomas de las mismas y su etiología. Metodología: el estudio fue retrospectivo, se revisaron todas las historias clínicas de los pacientes remitidos a ortóptica atendidos en un consultorio particular, entre los años 2004 y 2006, seleccionando los casos de parálisis diagnosticadas, el análisis se realizó empleando el programa excel y se estableció la prevalencia de las parálisis oculomotoras según su etiología, signos y síntomas; así como también género, edad y asociación sistémica. Resultados. la población estudiada fue en total 3808 historias de las cuales, se obtuvo 30 casos positivos de parálisis oculomotoras lo cual representó el 0.78 por ciento de la muestra analizada.

Oculomotor paralysis is a total loss of the ocular musclefunction. The objective of this work was to establishthe prevalence of oculomotor paralysis in orthopticconsultation, to define the signs and symptoms as wellas their etiology. Methods: this was a retrospectivestudy. All the clinical records between 2004 and2006 whose patients were remitted to orthopticconsultation in a private doctor’s office were checked.Cases diagnosed with paralysis were chosen. Theanalysis was done through Excel and the prevalence ofoculomotor paralysis was established according to theiretiology, signs and symptoms. It also took into accountage, gender and systemic association. Results: a totalof 3808 clinical records were studied, out of which 30cases had oculomotor paralysis, which represented0.78 percent of the analyzed sample.