Does the use of Testosterone Enanthate as a Form of Doping in Sports Cause Early Closure of Epiphyseal in Bones? / ¿El Uso de Enantato de Testosterona como Forma de Dopaje en el Deporte Causa Cierre Epifisiario Temprano de los Huesos?

The purpose of this research is to investigate the morphometric effects of short term usage of testosterone enanthate among the anabolic androgenic steroids used as doping by athletes on humerus bones of male rats. 30 rats (35 days) were utilized in this research. The rats were divided into three equal groups. For the experimental group (n= 10), testosterone enanthate at 10 mg/kg dose in 100 µl peanut oil diluents, for the peanut oil group (n= 10), peanut oil of testosterone enanthate' diluent (100 µl) was executed intraperitoneally 5 days in a week for 3 weeks. The control group (n= 10) was nourished without any practice for 3 weeks. All rats were euthanized end of the research. Humerus bones were exposed by the dissection of rats' front extremite bones and measurements and the averages were taken. When the length of rats' humerus bones were analyzed, the growth of humerus bones of rats testosterone enanthate applied in the experimental group stopped significantly and the difference was significant (p<0.05). It was observed that among anabolic androgenic steroids, testosterone enathate's usage on male rats in puberty period caused early epiphyseal closure and stopped the growth of humerus bones significantly.

El objetivo de esta investigación fue estudiar en el húmero de ratas macho, los efectos morfométricos del uso a corto plazo de Enantato de testosterona entre los esteroides anabólicos usados como dopaje por atletas. En esta investigación se utilizaron 30 ratas divididas en tres grupos iguales. Un grupo experimental (n= 10), que se le administró Enantato de testosterona en dosis de 10 mg/kg en 100 µl diluido en aceite de maní, a otro grupo sólo se le administró aceite de maní (n= 10). La administración fue realizada por vía intraperitoneal 5 días a la semana durante 3 semanas. El grupo control (n= 10) fue alimentado durante 3 semanas. Todas las ratas fueron sacrificadas al término de la investigación. Los húmeros fueron expuestos por disección, se realizaron las mediciones y se tomaron los promedios. Cuando se analizó la longitud de los húmeros se observó que su crecimiento en las ratas del grupo experimental que recibieron Enantato de testosterona, se detuvo de manera significativa (p<0,05). Se observó que entre los esteroides anabólicos androgénicos, el uso de testosterona en ratas macho en el periodo de la pubertad causó el cierre epifisario temprano y detuvo el crecimiento del húmero de manera significativa.

Biological and clinical research on male reproduction and fertility regulation.

Biological and clinical research on male reproduction and fertility regulation carried at the National Institute of Health and Family Welfare over the past 17 years has been highlighted in this review. Areas of research covered pertains to hormones in relation to sperm maturation and transport; fertilizing ability of spermatozoa under different experimental conditions; agents producing functional sterility; seasonal variations in primate reproduction; male infertility including semen biochemistry, differential diagnosis between obstructive and non-obstructive azoospermia and hormone therapy; vasectomy, reversible vasocclusion and vasanastomosis; and the use of cyproterone acetate and testosterone enanthate in male rhesus monkey and human volunteers for reversible contraception.