RESUMEN
Objective To explore the influence of different biological sources of thromboplastin reagent on prothrombin time (PT) detection .Methods The thromboplastin reagents sourced from the rabbit brain extract provided by the Shanghai Taiyang Bi‐ological Technology Co .,Ltd .and Shanghai Changdao Biological Technology Co .,Ltd .and recombination tissue factor were selected and used for detecting PT in the non‐Warfarin treatment group(group A ,38 cases) and the Warfarin group(group B ,43 cases) by the Sysmex CA7000 blood coagulation analyzer .The detection results from different sources of prothrombin reagents were com‐pared between the two groups and performed the statistical analysis .Results In the group A ,the detection results had no statistical differences among the reagent R1 ,R2 ,R3 and R4 (F=3 .42 ,P>0 .05 ,n=38);in the group B ,the detection results had statistical differences among the reagent R1 ,R2 ,R3 and R4 (F=57 .68 ,P0 .05) and between reagent R2 and R4(t=2 .09 ,P>0 .05) .Conclusion The detec‐tion results of PT by different sources of PT reagent in the non‐Warfarin treatment patients demonstrate no significant difference , but the detection results in the Warfarin treatment patients have highly significant difference;the recombination tissue factor throm‐boplastin reagent has higher sensitivity ,which used for monitoring PT in the warfarin treated patients should establish a new thera‐peutic standard value for avoiding to cause the misdiagnosis and mistreatment .
RESUMEN
OBJECTIVE: To study the hemostatic effects of Qishu gongxue granules. METHODS: Kunming mice and Wistar rats were randomly divided into five groups, i.e. normal control group, Fuke zhixuening group and Qishu gongxuening granules high-dose, medium-dose and low-dose groups. The change of coagulation time was compared among five groups. The value of PT and APTT were determined. Platelet aggregative function in rats was detected. RESULTS: Qishu gongxuening granules could reduce coagulation time of model mice and the level of PT and APTT in rats while it enhanced platelet aggregative function in rats. CONCLUSION: Qishu gongxuening granules can reduce coagulation time and it can be used for uterine bleeding. Hemostatic mechanism is associated with the production of plasmozyme and thrombokinase in the coagulation of blood and platelet aggregative function.
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The incidence of life-threatening anaphylactoid reactions during anesthesia has been increasing. Specific allergic reactions during anesthesia are usually due to muscle relaxants, barbiturates, local anesthetics, narcotics, radiocontrast media, antibiotics, and colloids. Thrombokinase, a hemostatic agent, has been used widely in clinical practice and severe anaphylactoid reactions to thrombokinase can occur rarely. We experienced two cases of anaphylactoid reactions after thrombokinase administration.
Asunto(s)
Anestesia , Anestésicos Locales , Antibacterianos , Barbitúricos , Coloides , Medios de Contraste , Factor Xa , Hipersensibilidad , Incidencia , Narcóticos , FarmacologíaRESUMEN
Coagulants have been used for a long time to promote the hemostasis during operation. We have carried out the study to see the effect of the thromboplastin preparation. Thrombokinase, on the coagulation mechanism, thrombin time, partial thromboplastin time, Ca++, and operation time and amount of bleeding in the twenty patients undergoing laminectomy or femur fracture operation. The patients were divided into two groups, in the control group(n=10), disllied water 20ml, and in the Thrombokinase group(n=10), 20ml of Thrombokinase(4 amles) was administered intravenously during 5 minutes. The results were as follows: 1) Prothrombin time and partial thromboplastin time were significantly prolonged in the control group compared to the Thrombokinase group(p0.05).3) There was no change in either blood pressure or pulse rate and also no side reaction during or after the Thromobkinase injection.