Clinical significance of Periostin expression in the replacement of primary permanent teeth / 中国现代医生

Objective To investigate the effect of periostin on bone remodeling and autophagy during the period of tooth replacement and to investigate the mechanism of action of periostin in regulating the balance of bone metabolism during the replacement of primary and permanent teeth.Methods Fifteen cases each of experimental and control groups were collected from the periapical periodontal disease and multiple teeth extracted for periapical adhesions in the author's hospital,the mRNA levels of periostin,bone metabolism genes,and autophagy genes were detected in the specimens by in situ hybridization.Osteoblasts were cultured in vitro,periostin was added to the culture medium of the experimental group,and the expression of bone metabolism proteins[receptor activator of nuclear factor-κb ligand(RANKL),osteoprotegerin(OPG)]and autophagy proteins(LC3,Beclin-1)in osteoblasts was detected by Western blot.Results In situ hybridization results showed that periostin expression in the experimental group was lower than that in the control group(P<0.05),RANKL,LC3,BECN1 expression and RANKL/OPG values were higher than those in the control group(all P<0.05),and no significant differences were seen in OPG expression(P>0.05);protein blotting showed that RANKL,RANKL/OPG,LC3Ⅱ,Beclin-1,LC3Ⅱ/LC3Ⅰ were lower in the experimental group than in the control group(all P<0.05),and no significant differences were seen in OPG and LC3Ⅰ than in the control group(P>0.05).Conclusion Periostin reduces inflammation-induced bone resorption by reducing RANKL expression and improving hyperautophagic state.

Awareness and knowledge of the general public at southern region of Saudi Arabia regarding dental implants

Aims: To assess the awareness, knowledge, and information sources regarding dental implants as anoption of treatment to replace missing teeth among patients in Jazan Province, Saudi Arabia.Materials and methods: The current study consisted of 14 questions used to assess the patients’awareness, expectations and level of knowledge of dental implants. Three categories of questionswere used, with the first one related to the patients’ knowledge and options for replacement of missingteeth, the second about dental implants and their providers, and the third on the techniques, materials,care, and durability of dental implants. The collected data was analyzed using Chi-square tests, and Pvalues less than 0.005 were considered significant. Results: A total of 380 subjects were divided intotwo groups, medical (40.3%) or non-medical (59.7%) related. We found that 85% and 71.0% of themedical and non-medical subjects, respectively know the importance of replacement of missing teeth,while 50% had known the different types of dental implants with no significance (P< .001) betweenthe two groups. Dentists were the sources of the information (43.3% and 34.8% for the medical andnon-medical groups respectively). Around 50% of the medical subjects thought that dental implantscame with a screw compared with 36.6% of non-medical subjects with value of P .025. In total, 60%-70% of respondents from both groups answered that dental implants should be provided by specialistsonly. Around 29% of all patients cited “lifetime” as the survival period of implants. Also, 52%-77%of the respondents related the implant site to the “the jaw bone,” with significant difference of P .000.Conclusions: The awareness and knowledge of the subjects were acceptable with higher percentageamong respondents in the medical group. Dentists followed by friends were the main sources ofinformation for dental implants. Dental implants are considered as the best choice for replacement ofmissing teeth with excellent durability and need of much more special care than natural teeth

Esthetic rehabilitation of single anterior edentulous space using fiber-reinforced composite

A fiber-reinforced composite (FRC) fixed prosthesis is an innovative alternative to a traditional metal restoration, as it is a conservative treatment method. This case report demonstrates a detailed procedure for restoring a missing anterior tooth with an FRC. A 44-year-old woman visited our department with an avulsed tooth that had fallen out on the previous day and was completely dry. This tooth was replanted, but it failed after one year. A semi-direct technique was used to fabricate a FRC fixed partial prosthesis for its replacement. The FRC framework and the pontic were fabricated using a duplicated cast model and nanofilled composite resin. Later on, interproximal contact, tooth shape, and shade were adjusted at chairside. This technique not only enables the clinician to replace a missing tooth immediately after extraction for minimizing esthetic problems, but it also decreases both tooth reduction and cost.

A Retrospective study on Branemark TiUnite(R) implant for mandibular posterior single tooth replacement / 대한치주과학회지

The purpose of this study was to evaluate 6 years cumulative survival rate (CSR, %) of mandibular posterior single tooth implants replaced with Branemark TiUnite(R) implant system. The findings from this study were as followed ; 1. The 112 (111 persons) single implants that were placed in the mandibular posterior region were successful except 4 cases and showed 96.42% CSR. 2. The 55 (55 persons) single implants that were placed in the mandibular first molar region were successful except 2 cases and showed 96.36% survival rate. And, among the 57 (56 persons) single implants replacing the mandibular second molar, 2 failed showing 96.49% survival rate. There was no significant statistical difference. 3. Among the total 112 implants, 5.0mm wide diameter implants were placed in 96 cases(85.7%) showing 96.9% survival rate. 4.0mm standard diameter implants were placed in 16 cases showing 93.8% survival rate. There was no significant statistical difference. 4. Long implants above 10.0mm length were placed 103 cases(91.0%) and showed 96.1% survival rate. Short implants within 8.5mm length were placed 9 cases and showed 100% survival rate. There was no significant statistical difference. 5. 37 implants placed in typeI,II bone quality were showed higher survival rate(100%) than that of 52 implants placed in typeIII, IV bone quality(92.3%). But, there was no significant statistical difference. In conclusion, Branemark TiUnite(R) implant showed successful results when replacing manbibular single molar.

Retrospective study on ITI SLA (sand-blasted, large-grit, acid-etched) implant for mandibular posterior single tooth replacement / 대한치주과학회지

The purpose of this study was to evaluate cumulative survival rate (CSR, %) of mandibular posterior single tooth implants replaced with ITI SLA (sand-blasted, large-grit, acid-etched) implant system and compare the CSR between first and second molar. The findings from the results were as follows; 1. Total of 158 implants were inserted into 147 patients. 68 patients were males, 79 patients were females and their mean age was 47.8 years. 98 implants were placed in first molar area and 60 implants were placed in second molar area. In terms of diameter, implants with wide diameter over 4.8mm dominated (91.1%). Implants with length over 10mm were used (96.2%). 2. In the two cases, there was a slight transient numbness which recovered within 1-2 months. Nine SynOcta screw type abutments demonstrated screw loosening. There were ten cases of crown fallen-out from decementation. 3. Only one failed out of 158 implants. The CSR was 99.4%. The CSRs for first molar and second molar were 99% and 100%, respectively. From the results, it was concluded that single tooth replacement implant in the mandibular posterior area, might be considered as the effective treatment modality comparable to the conventional crown and bridge.