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1.
Basic & Clinical Medicine ; (12): 381-384, 2018.
Artículo en Chino | WPRIM | ID: wpr-693906

RESUMEN

Objective To investigate the expression of γ-aminobutyric acid A receptor α1 subunit (GABAAα1) in the ventrolateral periaqueductal gray (vLPAG) in rats with formalin-induced acute pain. Methods The rats were randomly divided into two groups:control group(group C) and formalin-induced pain group(group F),12 rats in each group:0.9% sodium chloride solution or 2% formaldehyde 50 μL was injected into the ventral surface of right hind paw respectively. The pain scores were recorded for every 5 minutes and the mechanical pain threshold were recorded for every 10 minutes until 1 h. The expression levels of GABAAα1in vLPAG were determined by Western blot analysis in each group.Results The rats in formalin group showed significant nociceptive behaviors immedi-ately, such as paw withdrawal and/or paw licking. Results demonstrated that the rats exhibited a biphasic response to pain. The pain behavior scores in group F were significantly higher than that in group C (P<0.05),and the mechanical pain threshold in group F was decreased after injection compared with group C(P<0.05). The expression of GABAAα1 protein in group F was significantly higher than that in group C (P<0.05).Conclusions The up-regulation of GABAAα1 expression in ventrolateral periaqueductal gray is associated with the decrease of pain threshold in rats with acute pain.

2.
Chinese Pharmacological Bulletin ; (12)1987.
Artículo en Chino | WPRIM | ID: wpr-558158

RESUMEN

Aim To observe the effects of propofol on nociceptive response at ventrolateral periaqueductal gray(vlPAG) of rats and the possible role of GABA_A receptor in this prosses.Methods Sprague-Dawley(SD) female rats were randomized into each group.Bicuculline and propofol were microinjected into ventrolateral periaqueductal gray(vlPAG).The noxious response was evaluated by hot plate and formalin test.Fos-like immunoreactivity(FLI) neurons expressed in spinal dorsal horn(DH) induced by formalin intraplantar injection(sc) of one hindpaw were used as a neuroactive marker to observe the effects of propofol on the noxious transmission in DH.Results In hot-plate test,the hyperalgesia induced by propofol(10 g?L~(-1)) vlPAG microinjection was significantly antagonized about(70%),(71%) at 10 and 20 min after (bicu-)culline(25 mg?L~(-1)) vlPAG microinjection(P

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