RESUMEN
The effect of anesthetic drugs on the localization of adult worms in albino mice was compared. The animals with 56 days of infection were anesthetized with pentobarbital sodium, ether or chloroform. Perfusion was carried out immediately after, recovering the worms and classifying them in relation to their localization on the liver or portal vein and the mesenteric veins. Our results showed that pentobarbital sodium produced a greater displacement of the worms to the liver (89) than ether (76) and chloroform (34) did, when compared to the control group (22). The difference between pentobarbital sodium and ether was significant (p < 0.05). We suggest that anesthetic drugs may not be used in studies on the distribution of adult worms in several hosts.
Asunto(s)
Animales , Ratones , Cloroformo/farmacología , Éter/farmacología , Pentobarbital , Schistosoma mansoni , Hígado/parasitología , Vena Porta , Venas Mesentéricas/parasitologíaRESUMEN
Fêz-se um estudo comparativo entre os anestésicos éter etílico e uretana, em ratos (Wistar). Observou-se uma variaçäo significativa nos resultados apresentados, quando investigados radiofármacos para vias renais. Com uretana, a captaçäo renal aumenta progressivamente em virtude da inibiçäo da filtraçäo renal e esta começa a ser restabelecida com a eliminaçäo do efeito da anestesia. Utilizando-se éter etílico observa-se que o radiofármaco é eliminado rapidamente dos rins (filtraçäo tubular ou glomerular), evidenciando a preservaçäo da funçäo renal
Asunto(s)
Animales , Ratas , Uretano/farmacología , Riñón/efectos de los fármacos , Éter/farmacología , Anestésicos/farmacología , Biomarcadores , Ratas EndogámicasRESUMEN
Hemidecortication (HD) (left cerebral hemisphere) performed in rats with the aim of analyzing the modulating effect of the cerebral cortex on the hypothalamic-pituitary-adrenal axis. Corticosterone release induced either by or immobilization stress was evaluated in control (C) and HD rats. The percentage increase in corticosterone was greater in HD than in C rats after 15 min of ether stress (HD = 142%, C = 50%) and after 60 min of immobilization stress (HD = 197%, C = 126%). An in vitro test showed that the release of ACTH induced by corticotropin releasing hormone (CRH) from hemipituitary fragments from HD rats was not different from that in control rats. These results suggest an inhibitory effect of the cerebral cortex on the hypothalamus which may modulate the secretion of corticoptropin releasing peptides
Asunto(s)
Decorticación Cerebral , Éter/farmacología , Sistema Hipófiso-Suprarrenal/fisiología , Estrés Fisiológico/fisiopatología , Hormona Adrenocorticotrópica/metabolismo , Corticosterona/metabolismo , Restricción FísicaRESUMEN
Apresentam-se as bases farmacocinéticas para o emprego do éter a 5% em soluçäo de glicose por via venosa. Descrevem-se os princípios para os cálculos das quantidades a serem administradas, de acordo com os princípios expostos por Brody e desenvolvidos por Lowe para a anestesia quantitativa. A técnica preconizada é descrita com detalhes, quando se utiliza ventilaçäo com oxigênio puro e com misturas de óxido nitroso. As vantagens e as desvantagens säo descritas, ressaltando-se a segurança associada ao baixo custo de sua aplicaçäo