Asunto(s)
Humanos , Evaluación de Síntomas/estadística & datos numéricos , Atención Ambulatoria , COVID-19/diagnóstico , Servicio Ambulatorio en Hospital/estadística & datos numéricos , Examen Físico , Atención Primaria de Salud , Sesgo , Sesgo de Selección , Tos/diagnóstico , Tos/etiología , Ageusia/diagnóstico , Ageusia/etiología , Pandemias , Fiebre/diagnóstico , Fiebre/etiología , Evaluación de Síntomas/clasificación , Revisiones Sistemáticas como Asunto , SARS-CoV-2 , Anosmia/diagnóstico , Anosmia/etiología , COVID-19/complicacionesRESUMEN
Two commonly used tastants, sucrose and sodium chloride, were applied to the tongue surface of rats while recording was made from their gustatory peripheral nerve, chorda tympani [CT]. This multiple unit recording was performed in the presence of different doses of clonidine, an antihypertensive drug. Clonidine, in low doses [0.15, 0.25 mg/kg, intraperitoneally] caused a significant decrease in the relative integrated neural responses of the rats' CT to NaCl [0.1 M] and sucrose [0.5 M] as compared to the reference solution [NH4Cl] [p<0.05]. In these doses clonidine did not act selectively in response to these special tastants, but in higher doses [0.5 mg/kg], it attenuated the nerve response to sucrose, while no effect was elicited on the response to NaCl