A suitable procedure to choose antimicrobials as controlling agents in fermentations performed by bacteria

This work evaluated the influence of nitrofurantoin, erythromycin and streptomycin at 50, 25 and 12,5 (per cent) of the minimal inhibitory concentration (MIC) on maximum specific growth rate (µmax) and specific polymer accumulation rate (µPHB) of "Alcaligenes eutrophus", considered resistant to those antimicrobials. Nitrofurantoin strongly affected µmax even at 50(per cent) MIC. Streptomycin moderately affected µmax only at 50(per cent) MIC. Nitrofurantoin showed the most harmful effect on µPHB when 50(per cent) MIC was applied and erythromycin was not harmful.