RESUMEN
A systematic search for solasodine, an important staring material for the partial synthesis of steroidal hormones as well as other potentially bioactive constituents of various Solanum species of Brazil has been undertaken. Thus, the fruits of S. paludosum, S. asperum, S. sessiliforum and Solanum sp. were found to contain significant amounts of solasodine. The root bark of S. paludosum which showe durare like activity yelded tomatidenol and another yet unidentified alkaloid responsible for the biological activity. The fruits of S. asperum yelded a new spirosolane alkaloid, solaparnaine. The stem bark of S. pseudo-quina showed convulsive and exitatory activity from which (25S)-isosolafloridine was identified as the active principle. In addition, the latter alkaloid was also found to show antimicrobial activity.
Asunto(s)
Humanos , Plantas Medicinales/química , Alcaloides Solanáceos/aislamiento & purificación , Alcaloides Solanáceos/farmacología , Esteroides/aislamiento & purificación , Esteroides/farmacología , Brasil , AntiinfecciososRESUMEN
Se realiza un estudio fitoquímico de la corteza del tallo del Solanum didymacanthum, que crece en la Sierra Cristal. Se describe el método de extracción, separación y purificación de los componentes esteroidales. Se aíslan e identifican por sus constantes físicas y características espectroscópicas, diosgenina, solasodina y 25 isosolafloridina