Antipyretic activity of diacetyl para-amino phenol.

Diacetyl para-amino phenol (DAPAP) was generated by interaction between aspirin and paracetamol in a mechanical shaker. It revealed antipyretic activity in albino rats. The antipyretic action was found to be having the same onset of action and duration as that of aspirin. This compound lacked ulcerogenic and analgesic activity. DAPAP therefore may have safety as an antipyretic drug in patients with history of peptic ulcer.

Paracetamol: estudo cromatográfico (CCD) de soluçöes semi-aquosas e demonstraçäo da interferência do P-Aminofenol sobre as análises quantitativas realizadas por espectrofotometria U.V / Paracetamol: chromatographic (TLC) studies of the semi-aqueous solutions and p-aminophenol interfering on spectrophotometric quantitative analysis

Soluçöes de paracetamol 100mg/ml, constituídas por misturas binárias água/polietilenoglicol 400 e água/álcool etílico absoluto, submetidas e näo submetidas a tratamento térmico, foram analisadas através de cromatografia em camada delgada. Tais estudos, acrescidos de varredura do espectro de absorçäo U.V., confirmaram a interferência exercida pelo p-aminofenol sobre as análises quantitativas, realizadas através de espectrofotometria U.V. a 244nm