Synthesis of some parabanic acid and thiazoline derivatives coumarines with expected pharmacological activity part II

New parabanic acids and thiazolines derived from different coumarinyloxyacetic acid hydrazides have been prepared and subjected to preliminary pharmacological screening. Some of the tested compounds showed anticonvulsant activity

Synthesis of some new 4 [3H] -Quinazolines as potential anticonvulsants

Condensation of various 4H-3.1 benzoxazin-4-ones [III] with homoslfanilamide afforded some new derivatives of 3-[p-sulfamoylbenzyl]-4 [3H]-quinzolinone [V]. Some o-amido-N- [p-sulfamoylbenzyl]-benzamides [IV] were isolated as reaction intermediates. Structures of the newly synthesized compounds were confirmed by IR, 1H-NMR, MS and elemental analyses. Several target compounds [V] exhibited good anticonvulsant effects against pentylentetraxol -induced convulsions in frogs. Compound [V-4] was 2.33 times as potent as phenobarbitone

N-phenylaminosuccinimide derivatives: potential convulsants related to ethosuximide with lower ionization parameters

The synthesis of two series of N-phenylaminosuccinimide derivatives [II] and some of their C-Mannich bases [III] was described. The structure of the new products was substantiated by spectral as well as microanalytical data. The pKa values and evaluation of the anti-MMS potency, for some selected compounds, were reported. Ethosuximide was utilized as prototype

electroresection of some 1,4-diazaspiro [5.5] under ane-3-imino-5-ones in aqueous buffered media at Hg cathode

The palarographic behavior of the title compounds in aqueous buffered media at DME was investigated. The mechanism of the electrode process was proposed and discussed. The identified resulting electrolysis product in high yield [70%] was the corresponding amino formed through the uptake of two electrons of the protonated imino, in a diffusion controlled irreversible process