Relation of mast cell, nerve and fibrosis in appendix.

The relationship of mast cells, nerves and fibrosis was studied in 50 cases of Appendix using simple histochemical technique. In the mucosa, the mast cell number was greater in the early stages of fibrosis. Both in the mucosa and submucosa mast cells were found closely associated with neural tissue. As the fibrosis increased this association between mast cells and neural tissue was retained only in the submucosa.

Neural hyperplasia in appendix.

One hundred fifty histologically non-inflamed appendices from patients with acute appendicular pain were studied for mucosal and submucosal neurogenous hyperplasia using simple histochemical stain. Mucosal and submucosal neural hyperplasia was found in 69.34% of cases. The severity of submucosal hyperplasia was more compared to mucosal. The neural hyperplasia of higher grade was found mainly in the age group between 21 to 40 years. The appendicular pain in three unwarranted surgical cases may be either due to neural hyperplasia or substances liberated from closely associated neuroendocrine/mast cells.