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1.
Journal of the Egyptian Society of Toxicology. 2009; 40: 1-9
en Inglés | IMEMR | ID: emr-91988

RESUMEN

This investigation was planned to clarify the anti-dyslipidemic therapeutic effects of a food product containing soybean and/or oat grains in experimental dyslipidemia. A total of 35 adult male albino rats were divided into five groups, normal control, dyslipidemic control, dyslipidemic experimental group fed with soybean product, dyslipidemic experimental group fed with oat grains product and dyslipidemic experimental group fed with the two products in combination Dyslipidemia was induced to rats by injection intraperitonealy with adrenaline. After 30 days of treatment with the plant products, data analysis revealed that there were highly significant increases in the serum concentrations of total cholesterol, low-density lipoprotein [LDL] cholesterol and triglycerides in the dyslipidemic group compared with the normal group. On the other hand, High-density lipoprotein [HDL] cholesterol concentration was highly significantly decreased. Administration of soybean product exhibited a significant decreasing effect on serum total cholesterol and LDL cholesterol concentrations, a significant increasing effect on serum HDL cholesterol level and an obvious improvement in serum triglycerides level which was not statistically significant. Treatment with oat grains containing product showed highly significant decreasing effect on the serum level of total cholesterol, non- significant improvement in LDL cholesterol concentration, a significant increasing effect on serum HDL cholesterol level and non- significant decreasing effect on the level of triglycerides. Administration of the two products in combination exhibited a significant decreasing action on total cholesterol concentration, a highly significant modulation in the impaired LDL cholesterol level, a highly significant increasing effect on serum I-1DL cholesterol level and a significant reduction in triglycerides level as compared with the dyslipidemic control group. The current data demonstrated that regular consumption of whole soybean and oat grains products exhibited marked anti-dyslipidemic modulatory actions on the impaire4 serum lipid and lipoprotein profiles in adrenaline-induced experimental dyslipidemia. Generally, the effect of the two products in combination was more effective than the effect of cacti of them alone


Asunto(s)
Masculino , Animales de Laboratorio , Hiperlipidemias/terapia , Glycine max/efectos de los fármacos , Avena/efectos de los fármacos , Plantas , Ratas , Colesterol/sangre , /sangre , Lipoproteínas HDL/sangre , Resultado del Tratamiento , Triglicéridos/sangre
2.
Rev. argent. dermatol ; 87(2): 100-105, abr.-jun. 2006. ilus, graf, tab
Artículo en Español | LILACS | ID: lil-634313

RESUMEN

Los polifenoles (flavonoides y antocianinas) están ampliamente distribuidos entre las diferentes especies vegetales. Estos poseen gran capacidad antioxidante; existiendo correlación positiva entre la actividad antioxidante y los polifenoles totales. El objetivo de este trabajo fue evaluar: 1° El contenido de polifenoles y antocianas totales de semillas, glumelas y extracto acuoso de Avena sativa L. 2° El efecto de la aplicación tópica de extracto acuoso de avena en 45 casos (10 mujeres y 35 hombres, entre 1 y 56 años de edad) con dermatitis atópica, dermatitis de contacto irritativa y dermatitis de contacto alérgica; y 30 controles normales (15 mujeres y 15 hombres, entre 1 y 60 años de edad). Tratamiento: aplicación de compresas del extracto crudo de avena en la piel dañada durante 5 minutos, seguida de la colocación de la biomasa (T°= 33 + 2°C) cubierta por una tela de gasa durante 5 minutos. Dicha biomasa se retira con el extracto de avena líquido. Entre 1 y 36 meses de iniciado el tratamiento se observó remisión de los síntomas cutáneos. El extracto acuoso, la biomasa de Avena sativa L., glumelas y semillas enteras contenían 6.12+0,45, 46,11+0,36, 212,81+0,19 y 286,60+0,50 mg/100 g ác. Gálico, respectivamente, de polifenoles totales.


Polyphenols (flavonoids and anthocyanins) are widely spread among the different vegetables species. They have a big antioxidant capacity. One important correlation exists between the antioxidant activity and the quantity of total polyphenols. The objective of this work was to evaluate: 1- the contents of polyphenols and anthocyanins of whole seeds, glumes and aqueous extract of Avena Sativa L., 2- the effects of topical application of aqueous extract of Avena sativa L. in 45 patients (10 females and 35 males, between 1 and 56 years olds) with Atopic Dermatitis, Contact Irritative Dermatitis and Contact Allergic Dermatitis, and 30 normal controls (15 females and 15 males, between 1 and 60 years olds). Treatment: were applications of compress of aqueous extract Avena Sativa L over the damaged skin for approximately five minutes, immediately after, one must cover with the biomass of oat (T° = 33 + 2 C°) and a clothe for five minutes. The biomass was removed using the Avena Sativa L. acqueous extract. Remissions of the cutaneous symptoms were noticed between 1 and 36 months after the beginning of the treatment. Aqueous extract, Avena Sativa L. biomass, glumes and whole seeds contents were: 6.12+0.45; 46.11+0.36, 212.81+0.19 y 286.60+0.50 mg/100 g gallic ac., respectively, of total polyphenols.


Asunto(s)
Humanos , Masculino , Femenino , Lactante , Preescolar , Niño , Adolescente , Adulto , Persona de Mediana Edad , Avena/efectos de los fármacos , Extractos Vegetales/uso terapéutico , Dermatitis Alérgica por Contacto/terapia , Dermatitis Atópica/terapia , Dermatitis Irritante/terapia , Polifenoles/administración & dosificación , Polifenoles/biosíntesis , Polifenoles/uso terapéutico
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