Erosive oral lichen planus and its management: a case series.

Lichen planus (LP), although a dermatosis, is more common in the oral mucous membrane than in the skin. Lesions of oral LP are classically found on the buccal mucosa and gingiva. Among the various types, the reticular lesions are asymptomatic and require no treatment, but pain and severe discomfort accompany the erosive or ulcerative lesions. Malignant transformation to squamous cell carcinoma developing in areas of erosive oral LP (EOLP) being a possibility, it is important for clinicians to maintain a high index of suspicion for all intraoral lichenoid lesions. Therefore, periodic follow-up of all patients with EOLP is recommended. In view of the above, this paper highlights the management of four cases of EOLP with topical corticosteroid and CO2 laser surgery.

Comparison of dexpanthenol and zinc oxide ointment with ointment base in the treatment of irritant diaper dermatitis from diarrhea: a multicenter study.

BACKGROUND: Severity of irritant diaper dermatitis (IDD) from diarrhea varies from patient to patient depending on the nature of feces and the number of bowel movements. The purpose of the present study was to compare the effectiveness of dexpanthenol and zinc oxide ointment with ointment base in the treatment of irritant diaper dermatitis from acute diarrhea in children by measuring transepidermal water loss (TEWL). MATERIAL AND METHOD: Forty-six children with diarrhea were prospectively, block randomized, investigator-blinded to receive dexpanthenol and zinc oxide ointment on one side and ointment base on the other side. TEWL was measured before and on days 1, 3, and 7 of treatment together with the assessment of severity score. The efficacy of treatment was defined by complete clearance of the lesion. RESULTS: TEWL in the treated and control side was not different before the application of the topical medication. In the present study, the efficacy of 5% dexpanthenol and zinc oxide ointment on D3 was 39% (18from 46 patients) compared to 32% in the ointment base side. On D7, the efficacy of the treated side was 58.7% and the ointment base side was 56%. The patients who still had skin lesions were those who had prolonged diarrhea. On the treated side, the mean of TEWL was lower than the control side on DI (p = 0.18) and had significant improvement on D3 (p = 0. 002). At the end of the present study, TEWL on the treated side was less than TEWL of the control side but it did not have statistical significance (p = 0.07). There was no rash or sign of abnormality on the treated side at the end of D7. CONCLUSION: In the treatment of lDD from acute diarrhea, 5% dexpanthenol and zinc oxide ointment significantly decreased TEWL in the treated side more than the ointment base on day 3 but the severity score was not significantly different on days 1, 3 and 7.

Identificación y cuantificación de benzocaina y eugenol en un ungüento analgésico dental / Identification and quantification of benzocaine and eugenol in a dental analgesic unguent

Se desarrolla un método analítico donde se describen las especificaciones de calidad para el ungüento analgésico dental. Se identifica la benzocaína por espectrofotometría en la zona UV en concentración de 10 y 100 *g/mL, y se determina el valor de la extinción específica en ambos máximos característicos para la benzocaína, utilizándose para la valoración. Se identificó y valoró el grupo amino aromático. Se demostró que los excipientes no interfieren en la valoración , y se obtuvo un recuperado de 100 ñ 2 % por los 3 métodos. Se propone un método para la valoración del eugenol, mediante la reacción de los grupos fenólicos presentes en la molécula, por fotometría con p-fenilendiamina sulfato en medio de bicarbonato de sodio y posterior oxidación con ferricianuro de potasio, locual forma un compuesto azul violáceo medible espectrofotométricamente a 596 nm; se comprobó en este máximo de absorción la conformidad con la ley de Beer. Se obtuvieron resultados reproducibles para la cuantificación del eugenol en el ungüento y se observó que ni la benzocaína, ni los excipientes de la formulación interfieren en este método